Allergic sensitization of the skin and oral mucosa to acrylic resin denture materials

Fisher, Alexander A.

doi:10.1016/0022-3913(56)90003-8

Cited by 78 publications

(26 citation statements)

References 7 publications

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“…In the literature on soreness of the mouth attributed to dentures made of acrylic, Fisher (1956) considered the liquid monomer as the cause, but Nyquist (1958) and Smith (1959) considered that other factors such as a defective fit of the denture could not be excluded and that the amount of available free monomer was insignificant. It would seem fairly certain that it is only free monomer which can cause allergy and that the amount of monomer which can escape from a polymerised mass containing as much as 5 per cent of residual monomer is very slight.…”

Section: Discussionmentioning

confidence: 99%

The Classic: The Bonding of Prostheses to Bone by Cement

Charnley

2010

Clinical Orthopaedics &Amp; Related Research

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Since the preliminary communication on the bonding of femoral head prostheses into the upper end of the femur by cold-curing acrylic cement (Charnley 1960) a total of 455 prostheses have now been inserted by this means.This report on experience with cold-curing acrylic cement in contact with living human bone is concerned with 1) the frequency of loosening of the cement-bone bond, as tested directly during re-exploration of the prosthesis or at necropsy; 2) the macroscopic, microscopic and radiographic appearances of the cement-bone bond in specimens; 3) the correlation of radiographic appearances with the state of fixation or looseness where this had been observed directly; 4) the best way to use the cement. Necropsy StudiesSix necropsy specimens were studied. Three were from patients who died of natural causes between one and a half and three and a quarter years after operation, who had undergone prosthetic replacement for fractures of the femoral neck. The clinical results had been classed as very good; the patients were seventy-two, eighty-one and eighty-five, and, though not very active during the last six months of their lives, had been fairly active before.The fourth specimen was from a patient of fifty-seven with severe polyarthritis who died one and a half years after operation from gold nephropathy.The remaining two specimens were from patients who died as a result of a second operation: one with ankylosing spondylitis who died of acute gastric dilation following spinal osteotomy five months after a successful ''low friction'' arthroplasty; the other, a woman of seventy-five with osteoarthritis, who died of myocardial failure after removal of the hip prosthesis which was necessary because of failure of the plastic acetabulum after three and a quarter years.In all of these specimens the femoral head prostheses were found to be rigidly fixed in the femur. The specimens, including the metal prostheses, were bisected with a metalcutting saw and photographed. Histological preparations were made after dissolving the cement with chloroform.In one specimen from a woman of seventy-two, which was typical of all six, a stainless steel Austin Moore prosthesis had been cemented in three and a quarter years before and a Teflon socket had been inserted as a

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Section: Discussionmentioning

confidence: 99%

The Classic: The Bonding of Prostheses to Bone by Cement

Charnley

2010

Clinical Orthopaedics &Amp; Related Research

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“…However, there have been many reports suggesting Release of methyl methacrylate from heat-cured and autopolymerized resins: Cytotoxicity testing related to residual monomer Ureporn Kedjarune, DDS, PhD* Nongluk Charoenworaluk, DDS, DipClinSc(Prosthodontics) † Sittichai Koontongkaew, DDS, PhD* that residual monomer in the denture base is related to mucosal irritation and sensitization of tissues. [1][2][3][4][5][6] Many studies have found that substances leached out from acrylic resin can cause irritation of oral tissue, inflammation, or even an allergic reaction. 3,7,8 Some researchers have also reported that autopolymerized acrylic resin has higher levels of residual monomer than heat-cured resin.…”

Section: Introductionmentioning

confidence: 99%

Release of methyl methacrylate from heat‐curved and autopolymerized resins: Cytotoxicity testing related to residual monomer

Kedjarune

Charoenworaluk

Koontongkaew

1999

Australian Dental Journal

141

131

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Three heat-cured and three autopolymerized acrylic denture bases with different mixing proportions and/or processing methods were investigated for the amount of residual monomer content and methyl methacrylate (MMA) released into saliva after incubation during the first and second 24 hours after processing. A corresponding range of concentrations of MMA was also used to test for cell cytotoxicity using a culture of human oral fibroblasts. The results showed that the amount of residual monomer was dependent not only on the type of polymerization but also on the amount of liquid in the mixture ratio and the processing method. The acrylic resin that had the lowest residual monomer also released the smallest amount of MMA but resins which have higher residual monomer may not necessarily release higher amounts of MMA. MMA, tested in the same range of concentration as the MMA found leached from acrylic resin in this study, was found to be toxic in the cell culture. Therefore, it is recommended that dentists attempt to reduce the amount of leachable substances before insertion of new dentures. In addition, it is recommended that dentists advise their patients not to wear newly made dentures overnight, as this may cause mucosal irritation from the potential accumulation of leachable substances.

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“…Correspondence: Dr. Darre, Frcidings All6 27, DK-2860 Soborg, Denmark Contact sensitization and toxic dermatitis to bone cement have been reported in dentists and dental laboratory technicians (Fisher 1956) and in orthopedic surgeous and nurses (Pegum and Medhurst 1971, Fries et al 1975, Fisher 1979, Kassis et al 1984. Surgical rubber gloves are not impervious to methylmethacrylate monomer (MMA) (Pegum & Medhurst 1971, Fries et al 1975, Waegemaekers et al 1983, Darre I % Vedell984).…”

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confidence: 99%