Allergic rhinoconjunctivitis continued to increase in Swedish children up to 2007, but asthma and eczema levelled off from 1991

Hicke-Roberts, A; Åberg, Nils; Wennergren, Göran; Hesselmar, Bill

doi:10.1111/apa.13433

Cited by 26 publications

(32 citation statements)

References 30 publications

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“…The prevalence of allergic disease including allergic rhinitis (AR) has increased over the past few decades in most countries worldwide [1, 2]. This change has occurred very rapidly, suggesting that there might be additional factors affecting the prevalence of allergic disease beyond genetic changes.…”

Section: Introductionmentioning

confidence: 99%

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis

Rui

et al. 2019

Int Arch Allergy Immunol

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Background: While early-life risk factors are known to influence the risk of allergies, the biological mechanisms underlying this observation are unclear. The aim of this study was to examine whether DNA methylation in childhood could underlie the association between early-life risk factors and allergic rhinitis (AR). Methods: In total, 234 patients, aged 6 years, were recruited, i.e., 114 were patients with AR (AR group) and 120 healthy children without AR (NAR group). The DNA methylation patterns of the IFN-γ promoter regions in CD4+ cells were analyzed using bisulfite sequencing. The percentage of Th1 was investigated by flow cytometry. The relationship among DNA methylation, early-life environment, and AR was examined. Results: After adjusting for several likely confounders, there was a higher likelihood of AR in children who had mothers with allergies than in children who had nonallergic mothers (OR = 5.19; 95% CI 1.18–29.41), in children who were born in autumn or winter than in children who were born in the summer or spring (OR = 2.69; 95% CI 1.34–5.40), and in children who lived with indoor carpet or wallpaper than in children who lived without indoor carpet or wallpaper (OR = 4.14; 95% CI 2.05–8.30). Compared to the NAR group, the AR group had higher mean methylation levels of the promoter region in IFN-γY, and lower numbers of IFN-γ+CD4+ cells were associated with autumn-winter birthdates. The season of birth had an indirect effect on AR at 6 years, which was mediated by the mean IFN-γ promoter methylation level. Conclusions: This study suggests that early-life environments affect AR, and this is supported by the finding of IFN-γY methylation as a mediator of the effect of an individual’s season of birth on AR.

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Section: Introductionmentioning

confidence: 99%

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis

Rui

et al. 2019

Int Arch Allergy Immunol

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“…Asthma is one of the most common chronic diseases in children and, following decades of increasing prevalence, it seems to have reached a high‐level plateau in western countries . School‐age asthma is considered to be a fairly homogeneous disease, with the majority of cases being related to allergic diseases, namely atopic asthma that is associated with allergic sensitisation, allergic rhinitis, food allergies or eczema .…”

Section: Introductionmentioning

confidence: 99%

Antibiotics in the first week of life were associated with atopic asthma at 12 years of age

et al. 2018

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AimThis study explored the prevalence of atopic and nonatopic asthma in 12‐year‐old children and whether they were associated with different risk factors. In particular, we wanted to analyse whether receiving antibiotics during the first week of life was associated with asthma at that age.MethodsData were obtained from a longitudinal cohort study of 5654 Swedish children born in 2003. The parents answered questionnaires from the age of six months until 12 years. The response rate at 12 years was 3637/4777 (76%).ResultsAt 12 years, 6.4% reported current doctor‐diagnosed asthma. Treatment with antibiotics during the first week of life was associated with an increased risk of atopic asthma, with an adjusted odds ratio of 2.2 and 95% confidence interval of 1.2–4.2. Being born small for gestational age was associated with an increased risk of nonatopic asthma, with an adjusted odds ratio of 3.8 and 95% confidence interval of 1.1–13.7. Asthma that only occurred with colds was reported by 28%.ConclusionAntibiotic treatment during the first week of life was associated with an increased risk of atopic asthma at 12 years, suggesting an immune‐mediated effect. Being born small for gestational age increased the risk of nonatopic asthma.

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“…The increased prevalence of allergic rhinitis is well known and a significant cause of morbidity in children and adolescents . Some studies suggest that although the increase in asthma is levelling off, allergic rhinitis continues to rise …”

Section: Introductionmentioning

confidence: 99%

Eating fish and farm life reduce allergic rhinitis at the age of twelve

Vasileiadou

Wennergren

Célind

et al. 2018

Pediatric Allergy Immunology

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Allergic rhinoconjunctivitis continued to increase in Swedish children up to 2007, but asthma and eczema levelled off from 1991

Abstract: The prevalence of ARC continued to increase between 1991 and 2007, but increases in asthma and eczema started to level off in 1991. Some geographical differences remained, but total allergy rates were similar in Kiruna and Mölndal in 2007.

Cited by 26 publications

References 30 publications

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis

Antibiotics in the first week of life were associated with atopic asthma at 12 years of age

Eating fish and farm life reduce allergic rhinitis at the age of twelve

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