Allergic rhinitis quality of life in urban children with asthma

Everhart, Robin S.; Kopel, Sheryl J.; Esteban, Cynthia A.; McQuaid, Elizabeth L.; Klein, Robert B.; McCue, Christine; Koinis-Mitchell, Daphne

doi:10.1016/j.anai.2014.02.002

Cited by 26 publications

(24 citation statements)

References 38 publications

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“…Despite the perception that the morbidity of allergic rhinitis is low, poor quality of life in patients with allergic rhinitis has been repeatedly reported. 50,51 …”

Section: Discussionmentioning

confidence: 99%

Allergic Diseases and Internalizing Behaviors in Early Childhood

Nanda

LeMasters²,

Levin³

et al. 2016

Pediatrics

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BACKGROUND AND OBJECTIVES The relationship between allergic diseases and internalizing disorders has not been well characterized with regard to multiple allergic diseases or longitudinal study. The objective of this study was to examine the association between multiple allergic diseases in early childhood with validated measures of internalizing disorders in the school-age years. METHODS Children enrolled in the Cincinnati Childhood Allergy and Air Pollution Study underwent skin testing and examinations at ages 1, 2, 3, 4, and 7 years. At age 7, parents completed the Behavior Assessment System for Children, Second Edition (BASC-2), a validated measure of childhood behavior and emotion. The association between allergic diseases at age 4, including allergic rhinitis, allergic persistent wheezing, atopic dermatitis, and allergic sensitization, and BASC-2 internalizing, anxiety, and depression T scores at age 7 was examined by logistic and linear regression, adjusting for covariates. RESULTS The cohort included 546 children with complete information on allergic disease and BASC-2 outcomes. Allergic rhinitis at age 4 was significantly associated with elevated internalizing (adjusted odds ratio [aOR]: 3.2; 95% confidence interval [CI]: 1.8–5.8), anxiety (aOR: 2.0; 95% CI: 1.2–3.6), and depressive scores (aOR: 3.2; 95% CI: 1.7–6.5) at age 7. Allergic persistent wheezing was significantly associated with elevated internalizing scores (aOR: 2.7; 95% CI: 1.2–6.3). The presence of >1 allergic disease (aOR: 3.6; 95% CI: 1.7–7.6) and allergic rhinitis with comorbid allergic disease(s) (aOR: 4.3; 95% CI: 2.0–9.2) at age 4 had dose-dependent associations with internalizing scores. CONCLUSIONS Children with allergic rhinitis and allergic persistent wheezing at age 4 are at increased risk of internalizing behaviors at age 7. Furthermore, multiple allergic diseases had a dose-dependent association with elevated internalizing scores.

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“…Despite the perception that the morbidity of allergic rhinitis is low, poor quality of life in patients with allergic rhinitis has been repeatedly reported. 50,51 …”

Section: Discussionmentioning

confidence: 99%

Allergic Diseases and Internalizing Behaviors in Early Childhood

Nanda

LeMasters²,

Levin³

et al. 2016

Pediatrics

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“…Patients may also suffer from sleep disorders, emotional problems, impairment in activities and social functioning [4]. Children with AR may have difficulties at school related to fatigue, irritability, and sleep disorders occurring due to nasal obstruction [5,6]. Social contact with parents and peers may also be negatively affected by the AR symptoms.…”

Section: Introductionmentioning

confidence: 99%

Quality of life in allergic rhinitis - children’s and their parents’ perspective in polish urban and rural population

Sikorska-Szaflik

Sozańska

2020

Health Qual Life Outcomes

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Background: Allergic rhinitis is a common chronic condition in the paediatric population. No reports regarding the quality of life in children with allergic rhinitis in the Polish population have been found in the available literature. The aim of this study was to assess and compare the quality of life in patients with allergic rhinitis reported by children and their parents living in a city and in rural areas, and to evaluate the possible relationships between the quality of life and the severity of symptoms. Methods: Two hundred and eight children with allergic rhinitis participated in the study (89 girls, aged 6-17, mean age 11.7 ± 3). Children were asked to evaluate their rhinitis symptoms by using two scales: the Total 4 Symptom Score and the Visual Analogue Scale. The quality of life assessment included the KINDL-R questionnaire. Results: Both for the T4SS and the VAS scale the severity of symptoms in children with seasonal rhinitis was significantly higher than in children allergic to perennial allergens. The quality of life total scores on the KINDL questionnaire was 45.6 ± 8.5 for the children and 73.7 ± 10.7 for the parents. In all the domains, except for physical health, the child's quality of life was rated significantly higher by parents than by children. The biggest discrepancy occurred in the domains: social contacts and family. Conclusions: Allergic rhinitis can disrupt the quality of life. Parents tend to overestimate their children's quality of life comparing to the children's own assessment. The quality of life in children with allergic rhinitis correlated with the severity of the clinical symptoms of the disease. Evaluation of the quality of life in children is an essential issue in clinical investigation of patients with allergic rhinitis. It is of great importance to ask children themselves about their quality of life than rely only on parental opinion.

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“…Moreover, our study cohort represents the subset of asthmatic children with uncontrolled asthma; it is also possible that in these children, rhinitis does not modify already uncontrolled asthma. As rhinitis has been shown to have a substantial quality of life impact on asthmatic children, 36 our results nonetheless elucidate novel associations with rhinitis that may lead to quality of life detriments in these urban children with uncontrolled asthma.…”

Section: Discussionmentioning

confidence: 62%

Mouse Sensitivity is an Independent Risk Factor for Rhinitis in Children with Asthma

Sedaghat

Matsui

Baxi

et al. 2016

The Journal of Allergy and Clinical Immunology: In Practice

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Background Although mouse and cockroach allergy are known to be important in urban children with asthma, the independent association of mouse and cockroach sensitization with rhinitis in these children is unknown. Objective To determine the association of mouse and cockroach sensitization with rhinitis in urban children with asthma. Methods As part of the Mouse Allergen and Asthma Intervention Trial, 499 urban children (5–17yr) with persistent asthma underwent spirometry, skin prick testing to 14 common environmental allergens, serology for mouse-specific IgE. In 269 subjects, cockroach-specific IgE serology was also obtained. Patient/parent-reported rhinitis in the last two weeks and one year were the primary outcome measures. Mouse/cockroach exposure was measured by reported frequency of sightings. Mouse allergen settled bedroom dust samples were also measured in mouse-sensitized children. Results Rhinitis was reported in 49.9% and 70.2% of participants within the last 2 weeks and last one year, respectively. Serum mouse IgE level ≥0.35IU/mL was associated with rhinitis in the past two weeks (ORadj=2.15, 95%CI= 1.02–4.54, P=0.04) and the past year (ORadj=2.40, 95%CI =1.12–5.1, P=0.02) after controlling for age, race, gender, the presence of any smokers at home, primary caregiver education level, number of allergen sensitivities, cockroach IgE level ≥0.35IU/mL and study site (Boston or Baltimore). Measures of home mouse exposure were not associated with rhinitis, regardless of mouse sensitivity. Cockroach sensitivity was not associated with rhinitis regardless of sensitization to other allergens. Conclusions In urban asthmatic children, increased mouse-, but not cockroach-, IgE in the sera (mouse IgE ≥0.35IU/mL) may be associated independently with rhinitis.

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Allergic rhinitis quality of life in urban children with asthma

Cited by 26 publications

References 38 publications

Allergic Diseases and Internalizing Behaviors in Early Childhood

Allergic Diseases and Internalizing Behaviors in Early Childhood

Quality of life in allergic rhinitis - children’s and their parents’ perspective in polish urban and rural population

Mouse Sensitivity is an Independent Risk Factor for Rhinitis in Children with Asthma

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