Allergic Rhinitis in Childhood and the New EUFOREA Algorithm

Scadding, Glenis; Smith, Peter; Blaiss, Michael S.; Roberts, Graham; Hellings, Peter; Gevaert, Philippe; Donald, Marinda Mc; Sih, Tânia; Halken, Susanne; Zieglmayer, Petra; Schmid‐Grendelmeier, Peter; Valovirta, Erkka; Pawankar, Ruby; Wahn, Ulrich

doi:10.3389/falgy.2021.706589

Cited by 42 publications

(81 citation statements)

References 78 publications

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“…Impact: on child’s daily activities, sleep and quality of life, measured using quality of life tools 1…”

Section: Historymentioning

confidence: 99%

“…Unilateral nasal obstruction is suspicious for a structural lesion. ENT (ear, nose and throat) referral should be made for those with unilateral signs, bleeding and structural septal abnormalities1 (figure 1). Also consider whether epistaxis is due to inappropriate nasal spray technique.…”

Section: Examinationmentioning

confidence: 99%

“…In a classic history and examination of AR without red flags, empirical treatment can be given in primary care without the need for initial testing. Recent guidelines have highlighted the importance of child-reported symptom scores1 and maintaining a step-up/step-down approach according to symptoms13 (figure 1 and box 2). Initial management is education regarding allergens and pollutants, including cigarette smoke, and advice regarding allergen exposure (a useful signpost is Allergy UK website) 14.…”

Section: Investigation and Managementmentioning

confidence: 99%

“…Initial management is education regarding allergens and pollutants, including cigarette smoke, and advice regarding allergen exposure (a useful signpost is Allergy UK website) 14. A nasal saline spray or wash can improve symptoms 1. The mainstay of treatment for moderate to severe disease is regular INCS5 of low bioavailability and suitable for children.…”

Section: Investigation and Managementmentioning

confidence: 99%

“…Rhinitis is defined as inflammation of the nasal mucosa, resulting in two or more symptoms including runny nose (rhinorrhoea), nasal obstruction, sneezing and nasal itch 1. It is an umbrella term for several entities including infectious, allergic and non-allergic rhinitis 2.…”

Section: Introductionmentioning

confidence: 99%

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Fifteen-minute consultation: Child with persistent runny nose

Powell

Berk

Bewick

et al. 2022

Arch Dis Child Educ Pract Ed

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A child with persistent runny nose may cause significant parental anxiety and healthcare utilisation. While the most common diagnoses are recurrent acute viral upper respiratory tract infections and allergic rhinitis, a careful history and examination is necessary to exclude other causes and to identify comorbidities. Treatment can then be tailored to the underlying cause. The aim of this article is to provide a systematic approach to such patients.

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“…Impact: on child’s daily activities, sleep and quality of life, measured using quality of life tools 1…”

Section: Historymentioning

confidence: 99%

Section: Examinationmentioning

confidence: 99%

Section: Investigation and Managementmentioning

confidence: 99%

Section: Investigation and Managementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fifteen-minute consultation: Child with persistent runny nose

Powell

Berk

Bewick

et al. 2022

Arch Dis Child Educ Pract Ed

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International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

Wise

Damask

Roland

et al. 2023

Int Forum Allergy Rhinol

106

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Background In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR‐Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence‐based findings and recommendation from the full document. Methods ICAR‐Allergic Rhinitis 2023 employed established evidence‐based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus was performed for each topic. The final document was then collated and includes the results of this work. Results ICAR‐Allergic Rhinitis 2023 includes 10 major content areas and 144 individual topics related to AR. For a substantial proportion of topics included, an aggregate grade of evidence is presented, which is determined by collating the levels of evidence for each available study identified in the literature. For topics in which a diagnostic or therapeutic intervention is considered, a recommendation summary is presented, which considers the aggregate grade of evidence, benefit, harm, and cost. Conclusion The ICAR‐Allergic Rhinitis 2023 update provides a comprehensive evaluation of AR and the currently available evidence. It is this evidence that contributes to our current knowledge base and recommendations for patient evaluation and treatment.

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Advances in noncoding RNA in children allergic rhinitis

Li,

Cui,

et al. 2024

Int Forum Allergy Rhinol

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Background: A chronic condition that significantly reduces a child's quality of life is allergic rhinitis (AR). The environment and allergens that the body is regularly exposed to can cause inflammatory and immunological reactions, which can change the expression of certain genes Epigenetic changes are closely linked to the onset and severity of allergy disorders according to mounting amounts of data. Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot be converted into polypeptides. The three main categories of ncRNAs include microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). NcRNAs play a crucial role in controlling gene expression and contribute to the development of numerous human diseases. Methods: Articles are selected based on Pubmed's literature review and the author's personal knowledge. The largest and highest quality studies were included. The search selection is not standardized. Results: Recent findings indicate that various categories of ncRNAs play distinct yet interconnected roles and actively contribute to intricate gene regulatory networks. Conclusion: This article demonstrates the significance and progress of ncRNAs in children's AR. The database covers three key areas: miRNAs, lncRNAs, and circRNAs. Additionally, potential avenues for future research to facilitate the practical application of ncRNAs as therapeutic targets and biomarkers will be explore.

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Allergic Rhinitis in Childhood and the New EUFOREA Algorithm

Cited by 42 publications

References 78 publications

Fifteen-minute consultation: Child with persistent runny nose

Fifteen-minute consultation: Child with persistent runny nose

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

Advances in noncoding RNA in children allergic rhinitis

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