Allergic rhinitis and non‐allergic rhinitis in children in the tropics: Prevalence and risk associations

Chiang, Wen Chin; Chen, Yu Ming; Tan, Henry K K; Balakrishnan, Abhilash; Liew, Woei Kang; Lim, Hwee Hoon; Goh, Si Hui; Loh, Wenyin; Wong, Petrina; Teoh, Oon Hoe; Goh, Anne; Chay, Oh Moh

doi:10.1002/ppul.22554

Cited by 38 publications

(42 citation statements)

References 31 publications

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“…There are few studies investigating the similarities and differences between AR and NAR both in children and in adults . All previous studies made a univariate comparison of clinical characteristics between AR and NAR . Our results are similar to some of these studies, such as persistence, seasonality, and severity of symptoms, which were also reported to be more common in patients with AR compared to patients with NAR .…”

Section: Discussionsupporting

confidence: 87%

“…Also, family history of atopy and AR were detected more often in AR than NAR in our study, similar to adult studies . On the other hand, nasal itching and nasal obstruction were not identified as discriminative between AR and NAR in our study.…”

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Predictive factors to differentiate between allergic and nonallergic rhinitis in children

Topal

Bakırtaş

Yılmaz

et al. 2014

Int Forum Allergy Rhinol

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 86%

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Predictive factors to differentiate between allergic and nonallergic rhinitis in children

Topal

Bakırtaş

Yılmaz

et al. 2014

Int Forum Allergy Rhinol

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“…In addition, allergic diseases such as eczema, rhinitis and wheeze that occur in early childhood may be without allergen sensitization [5]. However, knowledge about the association between early clinical phenotypes and the development of subsequent allergen sensitization is limited, as most studies have not assessed non-sensitized children, but have instead analyzed the association between early allergen sensitization and the subsequent development of allergic diseases [6, 7].…”

Section: Introductionmentioning

confidence: 99%

Predictors of allergen sensitization in Singapore children from birth to 3 years

Sim

Goh

Teoh

et al. 2016

Allergy Asthma Clin Immunol

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BackgroundImmune responses in allergic diseases begin with allergen sensitization, which usually occurs in childhood. Allergen sensitization involves a complex interplay of genetic and environmental factors, and sensitization patterns may change with age.ObjectiveTo determine the predictors of allergen sensitization in the first 3 years of life in the growing up in Singapore towards healthy outcomes (GUSTO) prospective birth cohort study.MethodsInterviewers collected information on demographics, family history of allergy, social and lifestyle factors, and the child’s health. We analyzed data from 849 children who completed skin prick testing (SPT) to inhalant allergens (house dust mites: Dermatophagoides pteronyssinus, Dermatophagoides farinae, and Blomia tropicalis) and food allergens (egg, peanut and cow’s milk) to assess risk factors for allergen sensitization at 18 months. To ensure that clinical phenotypes preceded allergen sensitization, we also analyzed data from 649 children who had a negative skin prick test at 18 months and completed skin prick testing at 36 months.ResultsWe observed a significant association between eczema reported before 18 months and a positive SPT at 18 months [aOR 4.5 (1.9–10.7)]. Ninety-five (14.6 %) children with negative SPTs at 18 months developed positive tests at 36 months. Onset of eczema before 18 months was associated with an increased risk of new allergen sensitization at 36 months among children non-sensitized at 18 months [aOR 3.4 (1.2–9.3)]. An association was seen between wheeze reported before 18 months and new allergen sensitization at 36 months [aOR 3.2 (1.1–9.1)]. We found no significant association, however, between rhinitis reported before 18 months and new allergen sensitization at 36 months.ConclusionsEarly onset of eczema and wheeze are risk factors for later allergen sensitization, suggesting a possible increased susceptibility to allergen exposure through an impaired skin barrier or defective airway epithelium. Trial registration NCT01174875 Registered 1 July 2010, retrospectively registered

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“…A recent retrospective analysis by Topal et al[10] regarding 472 consecutive children evaluated for CR within 1-year period, showed that 76.9% patients were diagnosed with AR and, thus, the remaining 23.1% children had NAR. Previously, another pediatric study by Chiang et al[11] enrolling 660 children (aged 1 to 18 year) with CR, provided very similar results, as AR was diagnosed in 75.9% cases and, by exclusion, NAR represented 24.1% of the total.…”

Section: Epidemiologymentioning

confidence: 64%

Non-allergic rhinitis in children: Epidemiological aspects, pathological features, diagnostic methodology and clinical management

Poddighe

Gelardi

Licari

et al. 2016

WJM

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Chronic rhinitis is a very common disease, as the prevalence in the general population resulted to be 40%. Allergic rhinitis has been considered to be the most frequent form of chronic rhinitis, as non-allergic rhinitis has been estimated to account for 25%. However, several evidences suggested that non-allergic rhinitis have been underrated, especially in children. In pediatrics, the diagnostic definition of non-allergic rhinitis has been often limited to the exclusion of an allergic sensitization. Actually, local allergic rhinitis has been often misdiagnosed as well as mixed rhinitis has not been recognized in most cases. Nasal cytology is a diagnostic procedure being suitable for routine clinical practice with children and could be a very useful tool to characterize and diagnose non-allergic rhinitis, providing important clues for epidemiological analysis and clinical management.

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Allergic rhinitis and non‐allergic rhinitis in children in the tropics: Prevalence and risk associations

Cited by 38 publications

References 31 publications

Predictive factors to differentiate between allergic and nonallergic rhinitis in children

Predictive factors to differentiate between allergic and nonallergic rhinitis in children

Predictors of allergen sensitization in Singapore children from birth to 3 years

Non-allergic rhinitis in children: Epidemiological aspects, pathological features, diagnostic methodology and clinical management

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