Allergic rhinitis and its pharmacology

Suleimani, Yousuf M. Al; Walker, Michael J.

doi:10.1016/j.pharmthera.2007.01.012

Cited by 54 publications

(75 citation statements)

References 299 publications

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“…AR occurs in a type 1 hypersensitivity reaction in which the cardinal symptoms of rhinitis (sneezing, watery nasal discharge, nasal obstruction and itching) are initiated by mast cell degranulation and histamine release (18,19). In addition to these wellknown pathways, alternative pathways are also responsible for the pathogenesis of AR.…”

Section: Discussionmentioning

confidence: 99%

Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Repor

et al. 2015

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Background: Allergic rhinitis is a common inflammatory nasal mucosal disease characterized by sneezing, watery nasal discharge, nasal obstruction and itching. Although allergen-specific antibodies play a main role in the allergic airway inflammation, neuronal inflammation may also contribute to the symptoms of allergic rhinitis. Neuronal inflammation is primarily caused by the stimulation of sensory nerve endings with histamine. It has been shown that neurotrophins may also have a role in allergic reactions and neuronal inflammation. Nerve growth factor, neurotrophin 3 (NT-3), neurotrophin 4/5 and brain-derived neurotrophic factor are members of the neurotrophin family. Although nerve growth factor and brain-derived neurotrophic factor are well studied in allergic rhinitis patients, the exact role of Neurotrophin-3 is not known. Aims: To investigate the possible roles of neurotrophin-3 in allergic rhinitis patients. Study Design: Case-control study. Methods: Neurotrophin-3 levels were studied in the inferior turbinate and serum samples of 20 allergic rhinitis and 13 control patients. Neurotrophin-3 staining of nasal tissues was evaluated by immunohistochemistry and ELISA was used for the determination of serum Neurotrophin-3 levels. Results: Neurotrophin-3 staining scores were statistically higher in the study group than in the control patients (p=0.001). Regarding serum Neurotrophin-3 levels, no statistically significant difference could be determined between allergic rhinitis and control patients (p=0.156). When comparing the serum NT-3 levels with tissue staining scores, there were no statistically significant differences in the allergic rhinitis and control groups (p=0.254 for allergic rhinitis and p=0.624 for control groups). Conclusion: We suggest that Neurotrophin-3 might affect the nasal mucosa locally without being released into the systemic circulation in allergic rhinitis patients.

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Section: Discussionmentioning

confidence: 99%

Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Repor

et al. 2015

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“…Anticholinergics act as muscarinic receptor blocker which inhibits mucus secretion and subsequent rhinorrhea. Through inhibiting degranulation and neosynthesis of inflammatory mediators, mast cell stabilizers are shown to be effective in reducing symptoms of early inflammatory phase and are useful for preventive purposes (Al Suleimani & Walker, 2007). Leukotrienes inhibitors significantly reduce nasal blockade by inhibiting leukotriene synthesis or serving as antagonists for its receptors.…”

Section: Traditional Management Of Allergic Rhinitismentioning

confidence: 99%

“…It has become progressively clear that it is a common comorbid condition with asthma, allergic conjunctivitis, sinusitis, otitis media, nasal polyposis and respiratory infections (Berrettini, et al, 1999;Skoner, 2000). Nasal obstruction can often be seen with pale nasal mucosa, enlarged turbinates, clear nasal secretions, and pharyngeal cobble-stoning upon physical examination (Al Suleimani & Walker, 2007). The diagnosis of AR was based on definite symptoms of nasal itching, rhinorrhea, sneezing, nasal obstruction or mouth breathing, as well as positive reactions to blood tests to antigens, such as house dust mite, cockroach, molds, feathers, grass pollen, weed pollens, sage pollen, and local tree pollens, etc.…”

mentioning

confidence: 99%

Phototherapy for the Treatment of Allergic Rhinitis

Hu¹,

Li²

2012

Allergic Rhinitis

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“…The latter may induce bronchial constriction, which is clinically expressed as asthma. Allergy therapies include not only symptomatic drugs, which provide release to the short-term effects associated to the release of these mediators (Al Suleimani and Walker, 2007;Bush and Saglani;Novak, 2009), but also allergen avoidance and specific immunotherapy. Only allergen avoidance and specific immunotherapy can radically modify the course of allergic diseases.…”

Section: Mechanisms Of Allergymentioning

confidence: 99%

Allergen Extract Analysis and Quality Control

Burastero¹

2011

Quality Control of Herbal Medicines and Related Areas

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Allergic rhinitis and its pharmacology

Cited by 54 publications

References 299 publications

Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Repor

Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Repor

Phototherapy for the Treatment of Allergic Rhinitis

Allergen Extract Analysis and Quality Control

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