Allergic rhinitis and asthma comorbidity: ARIA classification of rhinitis does not correlate with the prevalence of asthma

Antonicelli, Leonardo; Micucci, C.; Voltolini, Susanna; Feliziani, Vincenzo; Senna, Gianenrico; Blasi, P. Di; Visoná, Giovanni; Marco, Roberto de; Bonifazi, F.

doi:10.1111/j.1365-2222.2007.02729.x

Cited by 59 publications

(54 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The prevalence of AR among patients with asthma was similar to data found in the European Community Respiratory Health Survey (78%) (9). The pattern of severity and duration of rhinitis symptoms were also similar to the figures reported in a previous survey of the Belgian population (24) and surveys of patients recruited by general practitioners and chest physicians in other European countries (25,26). An unknown proportion of rhinitis symptoms might have been misclassified as nonallergic, because the presence of IgE-mediated sensitization to common allergens was not assessed in all patients but was based on the physicians' report.…”

Section: Discussionsupporting

confidence: 85%

The impact of concomitant rhinitis on asthma‐related quality of life and asthma control

Vandenplas

Dramaix

Joos

et al. 2010

Allergy

View full text Add to dashboard Cite

Background: Characterizing the interactions between the upper and lower airways is important for the management of asthma. This study aimed at assessing the specific impact of concomitant rhinitis on asthmarelated quality of life (QOL) and asthma control. Methods: A cross-sectional, observational survey was conducted among 1173 patients with asthma (aged 12-45) recruited by general practitioners and chest physicians. AR was defined by self-reported rhinitis symptoms and previously documented sensi-tization to inhalant allergens. The primary outcomes were (1) asthma control assessed by the Asthma Control Questionnaire (ACQ) and (2) asthma-specific QOL evaluated through the Mini Asthma Quality of Life Questionnaire (mAQLQ). Results: AR was present in 73.9% of the population with asthma and nonallergic rhinitis (NAR) in 13.6%. AR and NAR were associated with an increased risk of uncontrolled asthma (i.e. ACQ score > 1.5) with adjusted odds ratios (OR) of 2.00 (95% confidence interval [CI]: 1.35-2.97) and 1.77 (95%CI: 1.09-2.89), respectively. Multivariate linear regression analysis showed that AR and NAR had a modest, although significant, negative impact on the global mAQLQ score (beta coefficient: -0.293, standard error [SE]: 0.063 and beta coefficient: -0.221, SE: 0.080, P < 0.001, respectively), even after adjustment for the level of asthma control and demographic characteristics. Conclusion:This survey provides direct evidence that AR and NAR are associated with an incremental adverse impact on the disease-specific QOL of patients with asthma and the level of asthma control. Further investigations are required to determine whether appropriate treatment of rhinitis would efficiently reduce asthma morbidity.

show abstract

Section: Discussionsupporting

confidence: 85%

The impact of concomitant rhinitis on asthma‐related quality of life and asthma control

Vandenplas

Dramaix

Joos

et al. 2010

Allergy

View full text Add to dashboard Cite

show abstract

“…Patients with a sensitization to indoor and outdoor allergens are more prone to have asthma as a co-morbidity than those with indoor or outdoor allergy (1883). Although all patients with rhinitis may suffer from asthma (1885), patients with moderate/severe PER may be more likely to suffer from asthma than those with IAR and/or a milder form of the disease (67). Mucosal swelling was found to be common in asthmatics (1886).…”

Section: Epidemiologic Links Between Rhinitis and Asthmamentioning

confidence: 91%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,812

1,761

View full text Add to dashboard Cite

“…27 The nose and the bronchi are parts of a common airway with similar allergic inflammatory mechanisms, mediators, and lining cells, suggesting that asthma and AR may reflect manifestation of the same inflammatory process in different end organs (the lung and the nose). 27 While the conditions may reflect a parallel process affected by the same triggers, there is some evidence that AR and asthma severity do not occur in parallel 28 and that controlling AR may improve the control of asthma. 27 In healthy individuals, lung function exhibits a circadian rhythm, reaching a maximum in the afternoon and a minimum in the early morning.…”

Section: Co-morbid Conditionsmentioning

confidence: 99%

Factors accounting for asthma variability: achieving optimal symptom control for individual patients

Yawn

2008

Primary Care Respiratory Journal

View full text Add to dashboard Cite

Asthma is a variable disease, and various factors can lead to an increase (or decrease) in asthma symptoms and the level of asthma control. Pub Med was searched for recent articles dealing with asthma variability, environmental factors and co-morbid conditions that affect asthma control, and for publications which identified tools to facilitate patients' response to asthma variability. Variability in asthma symptoms may be a response to the individual's environment (e.g. seasonal variation, cigarette smoke, and air pollutants) or personal factors (e.g. inhaler technique, pregnancy, exercise). Co-morbid diseases such as allergic rhinitis may also impact significantly on asthma variability and control. Documenting asthma variability and assessing both adherence and possible triggers over time may allow patients and physicians to develop treatment programmes that anticipate, rather than follow, changes in the level of asthma symptoms. Personalised asthma control plans which take into account factors affecting symptom variability may enable patients to modify medication and their environment prophylactically in anticipation of a known trigger or at the first sign of an asthma exacerbation.

show abstract

Allergic rhinitis and asthma comorbidity: ARIA classification of rhinitis does not correlate with the prevalence of asthma

Abstract: In allergic rhinitis (AR) patients referred to a specialist, the features of AR as defined by the ARIA classification are not able to predict the presence of asthma, therefore all such patients should be assessed for asthma.

Cited by 59 publications

References 32 publications

The impact of concomitant rhinitis on asthma‐related quality of life and asthma control

The impact of concomitant rhinitis on asthma‐related quality of life and asthma control

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Factors accounting for asthma variability: achieving optimal symptom control for individual patients

Contact Info

Product

Resources

About