Allergic rhinitis and asthma assessment of risk factors in pediatric patients: A systematic review

Testa, Domenico; Bari, Matteo Di; Nunziata, Michele; Cristofaro, Generoso De; Massaro, Giuseppe; Marcuccio, Giuseppina; Motta, Giovanni

doi:10.1016/j.ijporl.2019.109759

Cited by 53 publications

(45 citation statements)

References 53 publications

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“…Our study showed significant male predominance for the development of AR in the examined age group. This finding is similar to other studies [9,10]. Before the onset of puberty, boys outnumber girls in terms of prevalence, but the trend reverses after puberty.…”

Section: Risk Factors For Cumulative Allergic Rhinitissupporting

confidence: 92%

Prevalence of allergic rhinitis, related comorbidities and risk factors in schoolchildren

Sultész

Horváth²,

Molnár

et al. 2020

Allergy Asthma Clin Immunol

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Background The study aimed to determine the prevalence and risk factors of allergic rhinitis and related comorbidities in school-age children in Budapest, capital of Hungary. Data and epidemiological studies on this disease are still limited. Methods A cross sectional study was conducted in 21 representative and randomly selected primary schools in 2019. International Study of Asthma and Allergies in Childhood-based questionnaires (n = 6869) inquiring about prevalence and related risk factors of allergic rhinitis were distributed to all parents. The data were characterised with standard descriptive statistics: frequencies (percentages) and means for categorical and quantitative data, respectively. Results 3836 of the questionnaires (1857 M/1979F) were completed. The prevalence of current allergic rhinitis was 29.3% (1043), physician-diagnosed allergic rhinitis was 9.7% (373), cumulative allergic rhinitis was 36.2% (1289) and current allergic rhinoconjunctivitis was 16.2% (577). The presence of physician diagnosed atopic disease–asthma (p < 0.0001, OR = 4.398, 95% CI 3.356–5.807), food allergy (p < 0.0001, OR = 2.594, 95% CI 1.995–3.378), and eczema (p < 0.0001, OR = 1.899, 95% CI 1.568–2.300)-were significantly related to an increased risk of cumulative allergic rhinitis. Significant factors associated with allergic rhinitis include male gender (p < 0.0001), family history of atopy (p < 0.0001), frequent upper respiratory tract infections (p < 0.0001), tonsillectomy (p = 0.0054), antibiotics given in the first year of life (p < 0.0001), paracetamol given in the first year of life (p = 0.0038), long-lasting common infections caused by viruses and/or bacteria before the appearance of the allergy (p < 0.0001), consumption of drinks containing preservatives or colourants (p = 0.0023), duration of living in Budapest (p = 0.0386), smoking at home (p = 0.0218), smoking at home in the first year of life (p = 0.0048), birds at home (p = 0.0119), birds at home in the first year of life (p = 0.0052), visible mould in the bedroom (p = 0.0139), featherbedding (p = 0.0126), frequent or constant heavy-vehicle traffic (p = 0.0039), living in a weedy area (p < 0.0001) and living in the vicinity of an air-polluting factory or mine (p = 0.0128). Conclusions The prevalence of allergic rhinoconjunctivitis in 6–12-year-old children in Budapest is higher than reported for most of the surrounding European countries. While asthma (OR = 4.398) is the most significant comorbidity, environmental factors such as birds at home in the first year of life (OR = 2.394) and living in a weedy area (OR = 1.640) seem to be the most important factors associated with AR. Strategies for preventive measures should be implemented. Trial registration number: KUT-19/2019. The study was approved by the Ethics Committee at Heim Pál National Pediatric Institute,

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Section: Risk Factors For Cumulative Allergic Rhinitissupporting

confidence: 92%

Prevalence of allergic rhinitis, related comorbidities and risk factors in schoolchildren

Sultész

Horváth²,

Molnár

et al. 2020

Allergy Asthma Clin Immunol

View full text Add to dashboard Cite

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“…Overuse of antibiotics is an urgent issue in worldwide and in China [ 1 , 2 , 3 ]. Several studies have investigated associations of antibiotics exposures during the early lifetimes with childhood asthma and allergies [ 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. However, conclusions among these studies were inconsistent.…”

Section: Introductionmentioning

confidence: 99%

First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses

Zou

Liu

Huang

et al. 2020

IJERPH

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Background: Associations of early antibiotics exposures with childhood asthma, allergies, and airway illnesses are debated. Objectives: We aimed to investigate associations of first-year antibiotics exposure with childhood asthma, allergies, and airway illnesses. Methods: A cross-sectional study was conducted among preschoolers in Shanghai, China during 2011–2012. A questionnaire regarding household environment and lifestyles and childhood health outcomes was reported by the child’s parents. Results: In total, 13,335 questionnaires (response rate: 85.3%) were analyzed and 3049 (24.1%) children had first-year antibiotics exposure. In the multivariate logistic regression analyses, first-year antibiotics exposure had significant associations with the higher odds of lifetime-ever pneumonia (adjusted OR, 95% CI: 2.15, 1.95–2.37), croup (1.46, 1.24–1.73), wheeze (1.44, 1.30–1.60), asthma (1.38, 1.19–1.61), food allergy (1.29, 1.13–1.46), and allergic rhinitis (1.23, 1.07–1.41), and as well as current (one year before the survey) common cold (≥3 times) (1.38, 1.25–1.52), dry cough (1.27, 1.13–1.42), atopic dermatitis (1.25, 1.09–1.43), wheeze (1.23, 1.10–1.38), and rhinitis symptoms (1.15, 1.04–1.26). These associations were different in children with different individual characteristics (age, sex, family history of atopy, and district) and other early exposures (breastfeeding, home decoration, pet-keeping, and environmental tobacco smoke). Conclusions: Our results indicate that first-year antibiotics exposure could be a strong risk factor for childhood pneumonia, asthma, allergies, and their related symptoms. The individual characteristics and other early exposures may modify effects of early antibiotic exposure on childhood allergies and airway illnesses.

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“…1 The prevalence of AR ranges from 10%~25% worldwide and 17%~28.5% of adults in European populations. 2 In China, a survey of self-reported AR over a 6-year period in the general Chinese adult population reported that the standardized prevalence of adult AR increased from 11.1% in 2005 to 17.6% in 2011. 3 We have conducted an epidemiological study in the grassland of Northern China and found the prevalence of physician-diagnosed AR is 18.8%.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and Response Predictors of Omalizumab in Treating Patients with Seasonal Allergic Rhinitis: A Real-World Study

Ma¹,

Wang²,

Wang³

2021

JAA

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Background: Omalizumab has been proven effective and safety in treating seasonal allergic rhinitis (SAR) by several randomized clinical trials in many countries. However, there is lack of clinical reports of Chinese patients with SAR treated by omalizumab. Objective: In the present real-world-designed study, we aimed to investigate the effectiveness of omalizumab in treating patients with SAR. Methods: SAR patients administered omalizumab in various dosages were recruited, and follow-up was done. Their quality of life (QOL) and symptoms were assessed by the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), Total Nasal Symptoms Score (TNSS), Asthma Control Test (ACT), and clinical outcomes were compared between postand pre-treatment conditions. Results: Sixty SAR patients received omalizumab therapy in the study (mean age 35.47 ±17.02 years, 35 females). Omalizumab treatment significantly improved the quality of life (change in RQLQ overall score: −2.08±1.01, paired t-test p<0.001) and nasal symptoms (change in TNSS: −7.33±2.50, paired t-test p<0.001) of SAR patients. In 21 patients with coexisting asthma, the ACT score significantly increased from 16.10 to 22.57 on average (paired t-test p<0.001), indicating better-controlled asthma. Using a threshold of ≥1 point improvement in RQLQ overall score, 83.3% of patients responded to omalizumab. The responder group had a higher baseline RQLQ score and TNSS (p<0.05), but both responders and non-responders had comparable scores after treatment. Multiple linear regression analysis identified the baseline RQLQ overall score as a predictor of change in the RQLQ score in omalizumab-treated SAR. Conclusion:Omalizumab is effective and safe in SAR treatment in a real-world setting.

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Allergic rhinitis and asthma assessment of risk factors in pediatric patients: A systematic review

Cited by 53 publications

References 53 publications

Prevalence of allergic rhinitis, related comorbidities and risk factors in schoolchildren

Prevalence of allergic rhinitis, related comorbidities and risk factors in schoolchildren

First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses

Effectiveness and Response Predictors of Omalizumab in Treating Patients with Seasonal Allergic Rhinitis: A Real-World Study

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