Allergic rhinitis aggravated by air pollutants in Latin America: A systematic review

Filho, Nelson Augusto Rosário; Satoris, Rogério Aranha; Scala, Wanessa Ruiz

doi:10.1016/j.waojou.2021.100574

Cited by 15 publications

(12 citation statements)

References 38 publications

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“…Wheezing, rhinorrhea, and dyspnea are main clinical symptoms of allergic rhinitis. Also, airway inflammation and remodeling, as well as hypersensitivity, are main pathophysiology mechanisms of this problem [1–3].…”

Section: Introductionmentioning

confidence: 99%

Survey the effect of drug treatment on modulation of cytokines gene expression in allergic rhinitis

Yang

et al. 2022

Fundamemntal Clinical Pharma

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Allergic rhinitis as common airway disease has high prevalence in all peoples worldwide. In allergic diseases, Th2 cells release type 2 cytokines that support the inflammation in airways. All the drugs used for allergic rhinitis do not cure completely, and the choice of drugs according to cost and efficacy is very important in all groups of atopic patients. Therefore, in this study, the effect of commercial drugs on cytokine gene expression has been studied. Male Balb/c mice were divided into six groups. Allergic rhinitis was induced in five of the six groups with ovalbumin, and four of these five groups were treated with salbutamol, budesonide, theophylline, and montelukast. The fifth group was used as positive control group and the sixth group as negative control group. For the survey, RNA was extracted, cDNA was synthesized, and quantitative real‐time PCR was done for 21 genes. The four drugs had different effects on mRNA expression of cytokines (IL‐1b, 2, 4, 5, 7, 8, 9, 11, 12, 13, 17, 18, 22, 25, 31, 33, 37, IFN‐γ, TNF‐α, TGF‐β1, and eotaxin) in the allergic rhinitis groups. Salbutamol can be used during pregnancy and breastfeeding, but it has some side effects. Budesonide in the inhaled form is generally safe in pregnancy. Theophylline cannot control allergic attack in the long run. Montelukast is not useful in the treatment of acute allergic attacks. Immunomodulatory and anti‐inflammatory effects of drugs in control of allergic rhinitis via Th2 cytokines can be new approaches in molecular medicine.

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Section: Introductionmentioning

confidence: 99%

Survey the effect of drug treatment on modulation of cytokines gene expression in allergic rhinitis

Yang

et al. 2022

Fundamemntal Clinical Pharma

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“…Al 10 de marzo de 2023, se reportan 4 487 553 casos confirmados y 219,539 fallecidos a nivel nacional (1) . Asimismo, en nuestro país, la prevalencia de rinitis alérgica puede llegar hasta 23% en Lima (11) , por encima del promedio en Latinoamérica (12) , debido a factores que incluyen una alta polución del aire (13) . En ese sentido, identificar una posible asociación con el compromiso pulmonar de nuestros pacientes infectados podría ser relevante.…”

Section: Introductionunclassified

“…As of March 10, 2023, reports showed 4,487,553 confirmed cases and 219,539 deaths nationwide 1 . Likewise, in Peru, the prevalence of allergic rhinitis can reach up to 23% in Lima 11 , above the average in Latin America 12 , due to factors like air pollution 13 . In this sense, identifying a possible association with pulmonary involvement in infected patients could be relevant.…”

Section: Introductionmentioning

confidence: 99%

Rinitis alérgica asociada al grado de compromiso pulmonar por COVID-19 en pacientes de un hospital general peruano

García-Gallo

Gonzales-Caldas

Urrunaga-Pastor

et al. 2023

Rev Peru Med Exp Salud Publica

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Objetivos. Evaluar la asociación entre rinitis alérgica y el grado de compromiso pulmonar en pacientes con COVID-19 y evaluar las frecuencias de las variables principales. Materiales y métodos. Se realizó un estudio de tipo observacional, transversal y analítico mediante la revisión de historias clínicas de pacientes atendidos en el Hospital Nacional Cayetano Heredia entre el año 2020 y 2021 con diagnóstico de COVID-19. Se determinó el antecedente de rinitis alérgica, y el compromiso pulmonar se evaluó mediante una tomografía sin contraste usando el puntaje tomográfico (PT), además de, variables sociodemográficasy clínicas. Se estimaron razones de prevalencias tanto crudas (RP) como ajustadas (RPa) con sus respectivos intervalos de confianza (IC) al 95% y se empleó un modelo lineal generalizado de la familia Poisson con función de enlace logarítmica y varianzas robustas. Resultados. Se evaluaron 434 pacientes predominantemente varones, mayores de 60 años y sin antecedentes médicos relevantes.El 56,2% tenía el antecedente de rinitis alérgica y el 43,1% tuvo un compromiso pulmonar moderado a severo. En el modelo de regresión ajustado, se encontró que el antecedente de rinitis alérgica disminuyó la gravedad de COVID-19 evaluada a través del compromiso pulmonar según el PT (RPa: 0,70; IC 95%: 0,56-0,88; p=0,002). Conclusiones. El antecedente de rinitis alérgica representó una disminución en la gravedad de COVID-19 según el PT score del 30,0% en pacientes hospitalizados.

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“…Allergic rhinitis (AR) is a common inflammatory reaction in the nasal mucosal membrane caused by allergen inhalation, such as animal dander, pollen, or air pollution [1,2]. Epidemiological data showed that about 40% of the global population suffers from AR, with an increasing annual incidence [3,4].…”

Section: Introductionmentioning

confidence: 99%

Abies holophylla Leaf Essential Oil Alleviates Allergic Rhinitis Based on Network Pharmacology

et al. 2023

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Abies holophylla is an evergreen coniferous species that has been widely used for treating pulmonary diseases and colds. Previous research has demonstrated the anti-inflammatory effect of Abies species and the anti-asthmatic activities of Abies holophylla leaf essential oil (AEO). As asthma and allergic rhinitis (AR) share pathophysiology and pharmacotherapeutic interventions, AEO inhalation can also ameliorate upper respiratory allergic diseases. This study explored the protective effects of AEO on AR with network pharmacological pathway prediction. The potential target pathways of AEO were analyzed by a network pharmacological approach. The BALB/c mice were sensitized by ovalbumin (OVA) and 10 μm particular matter (PM10) to induce allergic rhinitis. Aerosolized AEO 0.0003% and 0.03% were delivered by nebulizer for 5 min a day, 3 times a week for 7 weeks. Nasal symptoms (sneezing and rubbing), histopathological changes in nasal tissues, serum IgE, and zonula occludens-1 (ZO-1) expressions on nasal tissues were analyzed. After AR induction with OVA+PM10 and inhalation of AEO 0.0003% and 0.03% treatment, AEO significantly decreased allergic symptoms (sneezing and rubbing), hyperplasia of nasal epithelial thickness, goblet cell counts, and serum IgE level. The network analysis demonstrated that the possible molecular mechanism of AEO is highly associated with the IL-17 signaling pathway and tight junction. The target pathway of AEO was investigated in RPMI 2650 nasal epithelial cells. Treatment of AEO on PM10-treated nasal epithelial cells significantly reduced the production of inflammatory mediators related to the IL-17 signaling pathway, NF-κB, and the MAPK signaling pathway and prevented the reduction in TJ-related factors. When taken together, AEO inhalation may be considered as a potential treatment for AR by alleviating nasal inflammation and recovering the tight junction.

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Allergic rhinitis aggravated by air pollutants in Latin America: A systematic review

Cited by 15 publications

References 38 publications

Survey the effect of drug treatment on modulation of cytokines gene expression in allergic rhinitis

Survey the effect of drug treatment on modulation of cytokines gene expression in allergic rhinitis

Rinitis alérgica asociada al grado de compromiso pulmonar por COVID-19 en pacientes de un hospital general peruano

Abies holophylla Leaf Essential Oil Alleviates Allergic Rhinitis Based on Network Pharmacology

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