Allergic reactivity to Parthenium hysterophorus pollen: An ELISA study of 582 sera from the United States Gulf Coast

Wedner, H. James; Wilson, Patricia M.; Lewis, Walter H.

doi:10.1016/0091-6749(89)90334-5

Cited by 14 publications

(8 citation statements)

References 15 publications

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“…It is also found to be respon sible for the high incidence of rhinitis in the Brisbane region of Australia where P hysterophorus has spread in recent years [Stewart J.A., personal commun.]. The stud ies carried out by Wedncr et al [8,21] have stressed the im portance of this weed as a source of allergic rhinitis in the Gulf coast region of the US. The high degree of cross-reactivity between Parthenium and ragweed pollen allergens suggests that individuals sensitized to Parthe nium may develop type-I hypersensitivity reactions to ragweed and vice versa when they travel to regions in fested with the weed to which they were not previously exposed.…”

Section: Discussionmentioning

confidence: 99%

“…Among these, 28% were positive for both ragweed and Parthenium, while 30% and 8% of the total sera were positive only for ragweed or Parthenium allergens, respectively. Based on RAST and ELISA inhibition data obtained from the present investi gation and from earlier studies [21], it is clear that al though there is high degree of cross-reactivity between the two pollen allergens, they contain unique epitopes which are recognized by persons exposed to one or the other pollen.…”

Section: Discussionmentioning

confidence: 99%

“…5a, b), no clinical history is available to determine whether the anti bodies in the sera of the US patients were induced as a consequence of their exposure to ragweed alone or to both ragweed and Parthenium pollens. In a recent study, Wedner et al [21] examined sera collected from 582 indi viduals living in 18 US Gulf cities where P. hysterophorus and/or giant ragweed grows in profusion. IgE antibodies specific for one or both the pollen extracts were demon strable in 66% of the sera by ELISA.…”

Section: Discussionmentioning

confidence: 99%

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Allergenic Cross-Reactivity between <i>Parthenium</i> and Ragweed Pollen Allergens

Sriramarao

Rao

1993

Int Arch Allergy Immunol

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Cross-reactivity of allergens from the pollen of the Compositae weeds, Parthenium hysterophorus (American feverfew) and Ambrosia (ragweed), in 2 groups of patients with different geographic distributions was studied. Parthenium-sensitive Indian patients, who were never exposed to ragweed, elicited positive skin reactions with ragweed pollen extracts. A significant correlation in the RAST scores of Parthenium and ragweed-specific IgE was observed with the sera of Parthenium and ragweed-sensitive Indian and US patients, respectively. RAST inhibition experiments demonstrated that the binding of IgE antibodies in the sera of ragweed-sensitive patients to short (Wl) and giant (W3) ragweed allergen discs could be inhibited by up to 94% by Parthenium pollen extracts. Similar inhibition (up to 82%) was obtained when the sera of Parthenium rhinitis patients were incubated with ragweed allergen extracts. A dose-dependent proliferation of lymphocytes from a Parthenium-sensitive rhinitis patient with elevated levels of both Parthenium and ragweed-specific IgE was observed when incubated with Parthenium and ragweed pollen extracts. A 1.6-fold higher proliferation, however, was observed with Parthenium pollen extract at a concentration of 100 µg/ml. These results suggest that shared epitopes present on Parthenium and ragweed pollen allergens are recognized by both Indian and US patients sensitized by exposure to Parthenium and ragweed pollen, respectively. The high degree of cross-reactivity between Parthenium and ragweed pollen allergens suggests that individuals sensitized to Parthenium may develop type-I hypersensitivity reactions to ragweed and vice versa when they travel to regions infested with the weed to which they had not been previously exposed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Allergenic Cross-Reactivity between <i>Parthenium</i> and Ragweed Pollen Allergens

Sriramarao

Rao

1993

Int Arch Allergy Immunol

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“…The role of Parthenium in allergy in this region has been discussed. 3 Professor and Vice Chairman of Medicine. The University of Texas Medical Branch at Galveston.…”

Section: Allergensmentioning

confidence: 98%

Why Do They Wheeze?

Ja¹

1991

allergy asthma proc

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“…Studies of cross-reactivity among different ragweeds (short, giant, western and false) led to the interpretation that these ragweeds contain the same allergens in roughly comparable portions, whereas southern and slender ragweed possessed fewer of these allergens in lesser amounts. Other weed pollens which are considered to be clinically important include mugwort Artemisia vulgaris (Nilsen et al, 1991), Parthenium hysterophorus (Wedner et al, 1989), Parietaria (Corbi et al, 1986;Oreste et aL, 1991) and Plantago (Watson and Constable, 1991).…”

Section: Grass Aeroallergensmentioning

confidence: 99%

Aeroallergens of plant origin: Molecular basis and aerobiological significance

1995

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This review presents an update on the sources and molecular basis of aeroallergens of plants, derived from pollen, seeds, leaf and stem detritus and their protein molecules. These aeroallergens are a natural component of the atmosphere, either because of their natural function or human activity. Pollen is a source of allergens within the 10-200 #m size range, and while most allergenic pollen types account for only 20-30~ of total annual pollen catch, during their flowering season, they are usually the dominant type. Tree pollen commences the season in winter, with birch pollen counts in Scandinavia being the highest daily pollen counts yet reported and a major allergen, a 14-kDa protein, which is similar to pathogenesis-related proteins. Grass pollen follows in spring, and is unique as its two immunodominant allergens, a 35-kDa glycoprotein and 28-32-kDa protein, are in different cellular sites: the cytosol and surface of pollen grains; and in intracellular starch granules. The allergens at the pollen surface are not inhalable and can interact only with the eyes, nasal and oral cavities. Starch granules are released to the atmospheric aerosol when grains rupture in rainwater. These are a major source of allergen-containing micronic particles, which are important because they are inhalable. At the same time, allergen molecules are present in the aerosol, and these can bind to soot particles, and so be respired deep into the airways. The major Japanese cedar pollen allergen has been detected both within the pollen and in orbicules; particles less than 1 tLm that line the anther cavity and can be released into the air when dehiscence occurs. Ragweed is the major cause of late summer hayfever in eastern North America, where its pollen accounts for up to 41% of the annual pollen catch. It is a major source of aeroallergens in both respirable and non-respirable size ranges. As a result of human activity, dusts derived from seeds and cereal grains during transport, storage and milling provide a source of micronic particles, containing potent allergens that can trigger allergic disease.

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Allergic reactivity to Parthenium hysterophorus pollen: An ELISA study of 582 sera from the United States Gulf Coast

Cited by 14 publications

References 15 publications

Allergenic Cross-Reactivity between <i>Parthenium</i> and Ragweed Pollen Allergens

Allergenic Cross-Reactivity between <i>Parthenium</i> and Ragweed Pollen Allergens

Why Do They Wheeze?

Aeroallergens of plant origin: Molecular basis and aerobiological significance

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