Allergic reactions to Triatoma bites

Moffitt, John E.; Venarske, Daniel; Goddard, Jerome; Yates, Anne B.; deShazo, Richard D.

doi:10.1016/s1081-1206(10)62165-5

Cited by 55 publications

(36 citation statements)

References 16 publications

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“…In addition to acting as a vector, Culicoides are the primary cause of an extremely pruritic allergic dermatitis, known colloquially as "summer eczema", or "insect bite hypersensitivity" in horses (Anderson, et al, 1993;Kurotaki, et al, 1994). The saliva of kissing bugs (Triatominae) contains several allergens responsible for severe allergic reactions such as urticaria, dyspnea, and anaphylaxis in humans (Moffitt et al, 2003). This transcript, similar to one found in Culicoides, could be related to hypersensitivity or allergic responses by the human host.…”

Section: Similar To Culicoides Salivary Proteinmentioning

confidence: 97%

An insight into the sialome of the blood-sucking bug Triatoma infestans, a vector of Chagas’ disease

Assumpção

Francischetti

Andersen

et al. 2008

Insect Biochemistry and Molecular Biology

117

132

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Triatoma infestans is a hemiptera, vector of Chagas' disease, that feeds exclusively on vertebrate blood in all life stages. Hematophagous insects' salivary glands (SG) produce potent pharmacological compounds that counteract host hemostasis, including anti-clotting, anti-platelet, and vasodilatory molecules. To obtain a further insight into the salivary biochemical and pharmacological complexity of this insect, a cDNA library from its salivary glands was randomly sequenced. Also, salivary proteins were submitted to two dimentional gel (2D-gel) electrophoresis followed by MS analysis. We present the analysis of a set of 1,534 (SG) cDNA sequences, 645 of which coded for proteins of a putative secretory nature. Most salivary proteins described as lipocalins matched peptide sequences obtained from proteomic results.

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Section: Similar To Culicoides Salivary Proteinmentioning

confidence: 97%

An insight into the sialome of the blood-sucking bug Triatoma infestans, a vector of Chagas’ disease

Assumpção

Francischetti

Andersen

et al. 2008

Insect Biochemistry and Molecular Biology

117

132

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“…In addition, Triatoma bites most commonly cause local cutaneous and anaphylactic reactions in the United States [69][70][71][72][73][74]. Classically, the bites are painless and occur at night during sleep.…”

Section: Kissing Bugmentioning

confidence: 99%

Allergy to Miscellaneous Household Arthropods

Kim¹,

Hong²

2007

PPL

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Of the various arthropods, humans have the greatest contact with mites and cockroaches, and as a result, allergies to these two groups have been the most frequently reported. Changes in lifestyle and living environment have encouraged the growth of arthropods other than mites and cockroaches, and consequently, human exposure to antigens derived from the new arthropods has increased. Although systematic approaches to and immunobiochemical studies of these arthropods are relatively sparse compared with those of mites and cockroaches, recent reports have shown that many species of household arthropods can elicit IgE-mediated reactions via inhalation, biting, or stinging. In this chapter, we review the other arthropods that can induce allergic reaction to human beings. Where the information exists, the frequency of sensitivity and clinical manifestation, and the characterization of the allergens are also reviewed. Virtually all species of arthropods may be sources of allergens that can sensitize and induce IgE-mediated allergic reactions in humans.

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“…They are also known under the term ‘kissing bugs’. Anaphylaxis from their bites has been described already over 100 years ago, to date nearly 50 patients have been reported [31, 32]. Their nocturnal painless bite is found on uncovered skin and may result in local papules, bullae or urticaria.…”

Section: Systemic Reactions To Arthropodsmentioning

confidence: 99%

“…The patients typically wake up from itching cough and dyspnea, and may later develop the typical signs of anaphylaxis. An IgE-mediated mechanism has been demonstrated by RAST inhibition [32]. A major triatomine allergen has been identified and cloned.…”

Section: Systemic Reactions To Arthropodsmentioning

confidence: 99%

Systemic Immediate Allergic Reactions to Arthropod Stings and Bites

Bircher

2005

Dermatology

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Most of the encounters with biting and stinging insects result in more or less pronounced localized reactions. Typically, urticarial wheals and papular reactions are observed. Less often local bullous or hemorrhagic or disseminated papular reactions, particularly in children and immunologically naive adults, may be seen. With the exception of bee and wasp venom allergies, immediate-type allergic reactions to arthropod stings and bites are rare. Systemic IgE-mediated hypersensitivity has also been reported from additional hymenoptera species, e.g. hornets, bumble bees and ants. Rare are systemic reactions to mosquitoes, flies or kissing bugs and exceptional from ticks, bed bugs, moths, caterpillars and spiders. A major problem is the often lacking standardization of extracts for skin testing and for the determination of specific IgE. Some of the allergens have been characterized and few of them synthesized using recombinant techniques. Most investigations have been made with whole-body extracts or extracts from salivary glands, while desensitization has rarely been attempted. Currently, primary prevention by avoidance of stings and bites, and adequate instruction of sensitized individuals in the use of emergency drugs are mandatory.

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Allergic reactions to Triatoma bites

Cited by 55 publications

References 16 publications

An insight into the sialome of the blood-sucking bug Triatoma infestans, a vector of Chagas’ disease

An insight into the sialome of the blood-sucking bug Triatoma infestans, a vector of Chagas’ disease

Allergy to Miscellaneous Household Arthropods

Systemic Immediate Allergic Reactions to Arthropod Stings and Bites

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