Allergic Reactions to Sugammadex: A Case Series and Review of the Literature

Abstract

Sugammadex is a novel agent for the reversal of neuromuscular blockade; it acts by encapsulating ­rocuronium or vecuronium, eliminating the active compound from the circulation, thereby providing rapid and complete recovery even with profound or complete neuromuscular blockade. Clinical advantages, including reduced incidence of residual blockade, decreased nausea and vomiting, decreased dry mouth, less change in heart rate, and reduced pulmonary complications, have been demonstrated when comparing sugammadex to conventional agents, such as neostigmine, that inhibit acetylcholinesterase. Although generally safe and effective, anaphylactoid and allergic reactions have been reported with sugammadex. The potential for hypersensitivity reactions with sugammadex and previous reports from the literature, as well as diagnostic and treatment strategies, are presented in 3 pediatric cases.

Investigating Potential Sources of Sore Throat: Physico-Chemical Attributes and Microbial Contamination in Rambutan from Fresh Harvests and Retail Stores

“…These fruits contain cross-reacting antigens that can lead to allergic reactions including swollen eyes, itchy eyelids and a swollen throat. However, the prevalence of rambutan allergies remains unknown as most research has focused on other allergens like latex, medications and contrast agents (Banoub et al 2023;Blumenthal et al 2019). So far, the potential cause of throat inflammation after consuming rambutan from either a tree or a store has not been investigated.…”