Allergic Reactions to Serine Protease-Like Proteins of Staphylococcus aureus

Nordengrün, Maria; Abdurrahman, Goran; Janina, Treffon; Wächter, Hannah; Kahl, Barbara C.; Bröker, Barbara M.

doi:10.3389/fimmu.2021.651060

Cited by 10 publications

(5 citation statements)

References 26 publications

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“…The Staphylococcus aureus, and the Malassezia restricta , although not significantly modulated between EoE and healthy controls (Fig. 5 E and F), may underlie the pathogenesis in specific cohorts of patients (Factor-1 driven patient stratum) by stimulating the allergic response through the release of antigenic proteins [ 55 , 56 ], while the Pasteurella multocida may manipulate T cell differentiation through the release of specific toxins [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

A multi-omic analysis reveals the esophageal dysbiosis as the predominant trait of eosinophilic esophagitis

et al. 2023

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Background Eosinophilic esophagitis (EoE) is a chronic immune-mediated rare disease, characterized by esophageal dysfunctions. It is likely to be primarily activated by food antigens and is classified as a chronic disease for most patients. Therefore, a deeper understanding of the pathogenetic mechanisms underlying EoE is needed to implement and improve therapeutic lines of intervention and ameliorate overall patient wellness. Methods RNA-seq data of 18 different studies on EoE, downloaded from NCBI GEO with faster-qdump (https://github.com/ncbi/sra-tools), were batch-corrected and analyzed for transcriptomics and metatranscriptomics profiling as well as biological process functional enrichment. The EoE TaMMA web app was designed with plotly and dash. Tabula Sapiens raw data were downloaded from the UCSC Cell Browser. Esophageal single-cell raw data analysis was performed within the Automated Single-cell Analysis Pipeline. Single-cell data-driven bulk RNA-seq data deconvolution was performed with MuSiC and CIBERSORTx. Multi-omics integration was performed with MOFA. Results The EoE TaMMA framework pointed out disease-specific molecular signatures, confirming its reliability in reanalyzing transcriptomic data, and providing new EoE-specific molecular markers including CXCL14, distinguishing EoE from gastroesophageal reflux disorder. EoE TaMMA also revealed microbiota dysbiosis as a predominant characteristic of EoE pathogenesis. Finally, the multi-omics analysis highlighted the presence of defined classes of microbial entities in subsets of patients that may participate in inducing the antigen-mediated response typical of EoE pathogenesis. Conclusions Our study showed that the complex EoE molecular network may be unraveled through advanced bioinformatics, integrating different components of the disease process into an omics-based network approach. This may implement EoE management and treatment in the coming years.

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Section: Discussionmentioning

confidence: 99%

A multi-omic analysis reveals the esophageal dysbiosis as the predominant trait of eosinophilic esophagitis

et al. 2023

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“…Therefore, Spls are considered to be triggering allergens in the allergic airway response to S. aureus [ 78 ]. T cells of CF patients produced more TH2 cytokines after stimulation by Spls [ 84 ]. Increased IgE concentrations of Spls were detected in the serum of CF patients relative to healthy controls [ 84 ].…”

Section: Virulence Factors Of S Aureusmentioning

confidence: 99%

“…T cells of CF patients produced more TH2 cytokines after stimulation by Spls [ 84 ]. Increased IgE concentrations of Spls were detected in the serum of CF patients relative to healthy controls [ 84 ].…”

Section: Virulence Factors Of S Aureusmentioning

confidence: 99%

Exploring the Role of Staphylococcus aureus in Inflammatory Diseases

Chen

Zhang

et al. 2022

Toxins

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Staphylococcus aureus is a very common Gram-positive bacterium, and S. aureus infections play an extremely important role in a variety of diseases. This paper describes the types of virulence factors involved, the inflammatory cells activated, the process of host cell death, and the associated diseases caused by S. aureus. S. aureus can secrete a variety of enterotoxins and other toxins to trigger inflammatory responses and activate inflammatory cells, such as keratinocytes, helper T cells, innate lymphoid cells, macrophages, dendritic cells, mast cells, neutrophils, eosinophils, and basophils. Activated inflammatory cells can express various cytokines and induce an inflammatory response. S. aureus can also induce host cell death through pyroptosis, apoptosis, necroptosis, autophagy, etc. This article discusses S. aureus and MRSA (methicillin-resistant S. aureus) in atopic dermatitis, psoriasis, pulmonary cystic fibrosis, allergic asthma, food poisoning, sarcoidosis, multiple sclerosis, and osteomyelitis. Summarizing the pathogenic mechanism of Staphylococcus aureus provides a basis for the targeted treatment of Staphylococcus aureus infection.

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“…As recently reviewed by Coleman et al [ 90 ], the carriage of Staph A presents an increased risk for asthma (and other allergic conditions). This Gram-positive pathobiont has toxins and enzymes that can serve as allergens and sensitizing agents for the mucosal immune system [ 91 ]. Additionally, it can stimulate Th2 inflammatory cytokine production by epithelial cells that can result in barrier damage.…”

Section: Transforming Public Health For Impactful Successes Against the Ncd Epidemicmentioning

confidence: 99%

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Dietert

2021

Biomedicines

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The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. Included in the review is a discussion of the four priority behavioral modifications (food choices, cessation of two drugs of abuse, and exercise) advocated by the World Health Organization as the way to stop the ongoing NCD epidemic. The lack of public health focus on the majority of cells and genes in the human superorganism, the microbiome, is highlighted as is the “regulatory gap” failure to protect humans, particularly the young, from a series of mass population toxic exposures (e.g., asbestos, trichloroethylene, dioxin, polychlorinated biphenyls, triclosan, bisphenol A and other plasticizers, polyfluorinated compounds, herbicides, food emulsifiers, high fructose corn syrup, certain nanoparticles, endocrine disruptors, and obesogens). The combination of early life toxicity for the microbiome and connected human physiological systems (e.g., immune, neurological), plus a lack of attention to the importance of microbial rebiosis has facilitated rather than suppressed, the NCD epidemic. This review article concludes with a call to place the microbiome first and foremost in public health initiatives as a way to both rescue public health effectiveness and reduce the human suffering connected to comorbid NCDs.

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Allergic Reactions to Serine Protease-Like Proteins of Staphylococcus aureus

Cited by 10 publications

References 26 publications

A multi-omic analysis reveals the esophageal dysbiosis as the predominant trait of eosinophilic esophagitis

A multi-omic analysis reveals the esophageal dysbiosis as the predominant trait of eosinophilic esophagitis

Exploring the Role of Staphylococcus aureus in Inflammatory Diseases

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

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