Allergic Reaction to Latex from Stopper of a Medication Vial

An evidence-based approach to medication preparation for the surgical patient at risk for latex allergy: is it time to stop being stopper poppers?

“…In one report, the rubber stopper implicated in a latex allergy actually contained no DNR, but was initially misidentified by the manufacturer and the error was not discovered until after publication [24,[28][29][30] Table 1. In a second case report, a diabetic man with latex allergy noted improvement in a skin reaction at the site of injection after switching to an insulin preparation with a rubber stopper misidentified as non-latex [31].…”

“…Although the radioallergosorbent test was negative for latex antibodies, the neonate had a family history of latex allergy and the rash resolved when the TPN was administered from a vial with the stopper removed [43]. Vassallo et al [30] 1995 Case Report Methylprednisolone Anaphylaxis Stopper misidentified as containing latex. Towse et al [31] 1995 Case Report Insulin Rash Stopper misidentified as being non-latex.…”

Allergic Reactions in the Perioperative Period in Children

“…Skin lesions (localized or generalized erythema, hives with or without angioedema) were expressed alongside signs in other systems [17][18][19]21 The reactions attributable to latex were published among the most severe, grade III or IV, including cardiovascular events (low blood pressure, hemodynamic shock associated with tachycardia and bradycardia, and even cardiac arrest). These cardiovascular signs were mostly associated to respiratory symptoms (wheezing, bronchospasms) and sometimes to mucocutaneous signs [12,28,29,[31][32][33][34][35][36][37][39][40][41]74,75].…”

“…(Table 2) [17,18,20,23,24]. Also, when the reactions were related to latex, most reports were carried out using an adequate allergological evaluation [12,28,29,[32][33][34]36,37,[39][40][41]74].…”

Intravitreal ranibizumab, with or without filter?

“…(Montanari et al 1996) Latex allergy has been occasionally reported in patients injected from vials with rubber stoppers. (Vassallo et al 1995) However, this event is unlikely in patients treated with Lucentis Ò as the stopper is made of chlorobutyl rubber and is latex free.…”