Allergic Reaction to Latex: A Risk Factor for Unsuspected Anaphylaxis

Warpinski, James R.; Folgert, J.; Cohen, M.; Bush, Robert K.

doi:10.2500/108854191779011846

Cited by 35 publications

(14 citation statements)

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“…Background staining in GE, but not in SAP and ARL immunoblots, suggests that the glove eluate contains substances which may in terfere with antigen determination, e.g. polyisoprene subunits, altered proteins and glycoproteins formed during glove manufacture, or soluble carbohydrates originating from glove powder [19]. In our previous studies [2,15], we have used for prick testing, with sat isfactory results, an extract of the same glove brand as for the present immunoblot study.…”

Section: Discussionmentioning

confidence: 99%

Surgical Latex Glove Allergy: Characterization of Rubber Protein Allergens by Immunoblotting

Alenius

Turjanmaa

Palosuo

et al. 1991

Int Arch Allergy Immunol

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Immunoblot analysis employing IgE antibodies derived from sera of 3 physicians and 2 nurses allergic to surgical latex gloves, disclosed 10 allergens in natural rubber sap. Nine of the 10 allergens were detected in ammoniated natural rubber latex, but only 4 allergens in a latex glove extract. The allergenic proteins had apparent molecular weights ranging from 14 to 70 kD. Allergens with molecular weights of 14 and 21 kD showed the most intense immunoblot reactions suggesting that these proteins could be the major allergens in the natural rubber. An 11-kD protein and a 26-kD protein were only seen in the glove extract, indicating that they could be modified rubber proteins formed during glove manufacture.

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Section: Discussionmentioning

confidence: 99%

Surgical Latex Glove Allergy: Characterization of Rubber Protein Allergens by Immunoblotting

Alenius

Turjanmaa

Palosuo

et al. 1991

Int Arch Allergy Immunol

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“…They advised that care should be taken during surgical operations on these children [6]. Sensitization to latex is thought to occur even after only minimal contact via skin and airway.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, several authros have reported an intraoper ative anaphylaxis in children with spina bifida and have proven that it results from an IgE-mediated allergic reac tion to latex, which is a material used in many medical de vices [1][2][3][4][5][6]. Rubber hypersensitivity has also been recog nized as a common cause of contact dermatitis in Japan but, as yet, no connection has been made between it and IgE-mediated allergic reactions.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Latex Allergy in Atopic Children and Hospital Workers in Japan

Akasawa

Matsumoto

Saito

et al. 1993

Int Arch Allergy Immunol

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The incidence of latex-induced allergy has been reported to be increasing in Europe and the US but not in Japan. We thus measured latex-specific IgE antibodies and latex-specific IgG antibodies in sera from 196 atopic children with low serum IgE levels (under 1,000 U/ml; group 1), 108 atopic children with high serum IgE levels (over 1,000 U/ml; group 2) and 601 hospital employees (group 3). Atopic children were diagnosed as having asthma, atopic dermatitis and/or food intolerance. One out of group 1 (0.5%) and 11 out of group 2 (10.2%) were found to have latex-specific IgE by radioallergosorbent assay (RAST), and 7 were further found to be positive for latex antigen by skin test. Fifty-five percent of group 1, 65% of group 2 and 9.7% of group 3 were found to have latex-specific IgG over 100 units/ml by enzyme linked immunosorbent assay (ELISA). Prior to our diagnosis most of the children and employees did not realize they were allergic to latex. These data suggest that caution should be taken regarding latex allergy when atopic children have to be operated upon as atopic children tend to be sensitized to the latex antigen after even minimal contact with latex products.

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“…Ammoniation may unmask epitopes hidden in non-ammoniated latex [15]. Several groups [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] have analysed the molecular weights of allergens in latex (Table 1), but the patterns of reactivity vary greatly between the studies; as well as the large numbers of patterns, the picture is being confused by methodological differences such as the use of reduced and denatured proteins by some groups. No clear relationship has emerged between the type of symptom and allergens, but between allergens and patient group there is a suggestion that the 27-kD peptide in reduced/denatured latex may be the dominant allergen in spina bifida patients [28].…”

Section: (Accepted For Publication 6 September 1994 Jmentioning

confidence: 99%

Allergy toHevealatex

Pumphrey¹

1994

Clinical and Experimental Immunology

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Allergic Reaction to Latex: A Risk Factor for Unsuspected Anaphylaxis

Cited by 35 publications

References 0 publications

Surgical Latex Glove Allergy: Characterization of Rubber Protein Allergens by Immunoblotting

Surgical Latex Glove Allergy: Characterization of Rubber Protein Allergens by Immunoblotting

Incidence of Latex Allergy in Atopic Children and Hospital Workers in Japan

Allergy toHevealatex

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