Allergic Management of Meniere Disease

Shaver, Edward F.

doi:10.1001/archotol.1975.00780310018005

Cited by 13 publications

(14 citation statements)

References 15 publications

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“…The disease is suggested to be of multifactoral origin, cochlear endolymphatic hydrops being the pathophysiologic condition causing the disease. Numerous causes have been suggested, 1 including allergy, 2 viral infection, 3 autoimmune mechanisms, 4,5 altered glycoprotein metabolism, 6 and hormonal levels. 7 Although most cases of Ménière's disease are likely to be sporadic, there are numerous reports of familial cases.…”

Section: éNière's Disease Is Anmentioning

confidence: 99%

Inheritance of Ménière’s Disease in the Finnish Population

Klockars

Kentala²

2007

Arch Otolaryngol Head Neck Surg

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Patients: The study population comprised 118 patients with symptoms resembling Ménière's disease. The patients were divided into groups based on the diagnostic criteria by the Committee on Hearing and Equilibrium of the American Academy of Otolaryngology-Head and Neck Surgery. Main Outcome Measures: Relatives with Ménière's disease, geographic distribution of birthplaces of grandparents , symptoms, vestibular findings, and audiologic and otoneurologic tests. Results: Approximately 15% of the patients with definite Ménière's disease were found to represent familial disease. The majority of these patients were female, and they had more severe and intense attacks compared with patients with sporadic Ménière's disease. The mode of inheritance is autosomal dominant with incomplete penetrance. Conclusions: A significant part of Ménière's disease is inherited. The use of genetic isolates in which genetic homogeneity can be assumed might lead to the identification of gene defects leading to Ménière's disease.

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Section: éNière's Disease Is Anmentioning

confidence: 99%

Inheritance of Ménière’s Disease in the Finnish Population

Klockars

Kentala²

2007

Arch Otolaryngol Head Neck Surg

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“…Many studies suggest a relationship between allergy and the development o f Meniere's disease (MD) [1][2][3][4][5]. In some instances, an attack of MD has been closely related to expo sure to allergens in food and inhaled [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…In some instances, an attack of MD has been closely related to expo sure to allergens in food and inhaled [1][2][3]. Hsu et al [4] detected increased concentrations o f immunoglobulin E (IgE) in serum in 11% of individuals with MD relative to normal controls.…”

Section: Introductionmentioning

confidence: 99%

Recurrent Hearing Impairment and Nystagmus Induced by Repeated Antigen Exposure in Actively Sensitized Guinea Pigs

Minoda

Masuyama²,

Toriya³

et al. 1996

Int Arch Allergy Immunol

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Although many studies have suggested a relation between allergy and Ménière’s disease, the pathophysiology of this condition remains controversial. The aim of this study was to clarify whether an anaphylactic reaction in the inner ear can disturb hearing and equilibrium, and whether such disturbances recur in response to repeated anaphylactic reactions. Increases in audiological threshold, nystagmus, and endolymphatic hydrops were observed in response to a single exposure to antigen administered to actively sensitized guinea pigs. The increase in audiological threshold was maximal 10 h after antigen challenge (p < 0.005) and returned to the baseline level after 7 days. Nystagmus and the increase in audiological threshold induced by antigen exposure were inhibited by prior administration of pemirolast potassium (p < 0.05), an inhibitor of chemical mediator release from mast cells. A second challenge with antigen 7 days after the first also induced an increase in audiological threshold (p < 0.05) and nystagmus. These results suggest that studies of repeated antigen challenge in actively sensitized animal models may increase our understanding of the pathophysiology of Ménière’s disease.

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“…This makes it difficult to estimate the prevalence of food allergy. Some authors are of the opinion that food allergy is the most common allergy (8,9,28). Vaughan (31) found food allergy in 10% of a population.…”

mentioning

confidence: 99%

Secretory Otitis Media and Allergy

Ruokonen

Holopainen

Palva

et al. 1981

Allergy

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This study is an investigation on whether allergy, and especially food allergy, is more common in patients with secretory otitis media (SOM) than in others. At the same time, the effectiveness of the cytotoxic leucocyte test (CLT) as an aid in the diagnosis of food allergy was also studied. The material comprised 90 patients: 69 suffering from secretory otitis media and 21 without the disease as controls. Patients were studied using allergy history, ear status, tests for nasal and blood eosinophilic cells, total IgE, skin tests for 20 allergens. RAST for milk and wheat, immunoglobulin A, G and M, precipitating antibodies for milk and gluten. Mantoux test, and the CLT for 23 allergens. Allergy was found in 20% of the SOM patients and 10% of the control patients; the difference was not statistically significant. The best methods for verifying allergy were history, skin tests, and tests for nasal eosinophils cells. Laboratory tests could not verify objectively that food allergy was more common among SOM patients than controls, although 16% of the SOM patients compared with none of the controls had a history of food allergy. Of the tests used, the CLT correlated best with a history of allergy, but the results of the different tests were not in accordance wtih each other.

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Allergic Management of Meniere Disease

Cited by 13 publications

References 15 publications

Inheritance of Ménière’s Disease in the Finnish Population

Inheritance of Ménière’s Disease in the Finnish Population

Recurrent Hearing Impairment and Nystagmus Induced by Repeated Antigen Exposure in Actively Sensitized Guinea Pigs

Secretory Otitis Media and Allergy

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