Allergic Fungal Sinusitis Associated with Allergic Bronchopulmonary Aspergillosis: An Uncommon Sinobronchial Allergic Mycosis

Abstract

Independently of the signs linked to the organs involved (sinuses and bronchi) the mycological and immunoallergological features were similar for AFS and AFS associated with ABPA. AFS and ABPA can be isolated or associated in a sinobronchial allergic

Localized immunoglobulin E expression in allergic rhinitis and nasal polyposis

“…Patients with AFRS often display positive reactions to multiple fungal and nonfungal antigens on systemic allergy testing, indicating increased levels of systemic IgE to these antigens [26,[31][32][33][34]. Allergen-specific immunotherapy is often instituted in the treatment of patients with AFRS with good clinical results [35][36][37].…”

Allergic aspergillosis of the respiratory tract

“…The first report of AAS with concurrent ABPA was published in 1988 [200] and several more cases have been reported since [24,25,101,113,186,188,[201][202][203][204]. In a review of 95 patients with ABPA [186], radiological evidence of sinusitis was present in 22 patients.…”

Local and Systemic IgE in the Evaluation and Treatment of Allergy

“…Patients with AFRS frequently exhibit positive reactions to multiple fungal and nonfungal antigens, guiding subsequent allergen-specific immunotherapy. 32,[37][38][39][40][41] There is a subset of patients, however, who demonstrate the classic features of AFRS, but do not exhibit elevated systemic levels of total IgE. 32,42 In a 2004 study, Collins and colleagues 43 investigated a phenomenon termed ''entopy,'' or increased local IgE in the absence of systemic disease in AFRS.…”