Allergic disorders and their risk factors in primary Sjögren's syndrome

Increased prevalence of zinc hypersensitivity in patients with primary Sjögren syndrome: A case–control study

“…Furthermore, a recent study reported an increased prevalence of food and drug allergies in patients with pSS than in those with rheumatoid arthritis. 7 Interestingly, positivity rates to anti-Ro/SS-related antigen A autoantibodies are higher in pSS patients with drug allergies than in those without. 7 Stejskal et al demonstrated that most patients with connective tissue diseases, including pSS, have a higher prevalence of hypersensitivity to nickel, mercury, gold, and palladium and stronger metal reactivity than the healthy control group.…”

“…7 Interestingly, positivity rates to anti-Ro/SS-related antigen A autoantibodies are higher in pSS patients with drug allergies than in those without. 7 Stejskal et al demonstrated that most patients with connective tissue diseases, including pSS, have a higher prevalence of hypersensitivity to nickel, mercury, gold, and palladium and stronger metal reactivity than the healthy control group. 8,9 The same study revealed that mercury, gold, and palladium sensitivities are associated with restorative materials containing these metals.…”

“…3,4 Drug and skin-contact allergies are more common in patients with pSS than in those with other rheumatic diseases. [5][6][7] Notably, it has been suggested that delayed-type (type IV) hypersensitivity to environmental metals, which induces contact dermatitis and systemic inflammatory symptoms, underlies a subset of autoimmune diseases, such as pSS. 8,9 To better understand the contribution of metal allergy to pSS, a case-control study was conducted to assess the prevalence and severity of zinc, gold, nickel, and palladium hypersensitivity in a cohort of Japanese patients with pSS.…”