Allergic diseases and long-term risk of autoimmune disorders: longitudinal cohort study and cluster analysis

Krishna, Mamidipudi Thirumala; Subramanian, Anuradhaa; Adderley, Nicola J; Zemedikun, Dawit T; Gkoutos, Georgios V.; Nirantharakumar, Krishnarajah

doi:10.1183/13993003.00476-2019

Cited by 63 publications

(71 citation statements)

References 36 publications

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“…A recent meta-analysis30 reported that AR may increase the risk of rheumatoid arthritis when case-control and cohort studies with acceptable quality and low risk of bias were included. Similar observations were found in Sjögren's syndrome and psoriasis according to populational-based cohort studies by Esposito et al17 and Krishna et al29…”

supporting

confidence: 86%

“…It is worth noting that the association between SLE and other allergic diseases that frequently co‐exist with AR has also been reported. Krishna et al 29 demonstrated in their populational‐based study that patients with co‐existing AR and conjunctivitis had an increased risk of incident SLE. Similar findings were also observed in patients with asthma and eczema (with or without allergic rhinitis/conjunctivitis).…”

Section: Discussionmentioning

confidence: 99%

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Allergic rhinitis and risk of systemic lupus erythematosus: A systematic review and meta‐analysis

et al. 2020

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Allergic rhinitis (AR) is a hypersensitivity reaction driven by type 2 helper T cells (Th2) as a result of inhaled allergen-induced immunoglobulin E (IgE)-mediated inflammatory response at nasal mucosa. Common symptoms include rhinorrhea, sneezing, nasal pruritus and nasal obstruction. 1,2 AR is the most common cause of chronic rhinitis with the estimated prevalence of 15% to 30% in the United States and Europe. 2,3 Moderate and severe persistent AR not only affect patients' quality of life 4 but also contribute to substantial

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supporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Allergic rhinitis and risk of systemic lupus erythematosus: A systematic review and meta‐analysis

et al. 2020

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“…However, due to a relatively smaller sample size and study number in the previous study, the confidence interval was quite wide, which limited the possibility of making comparisons between the results of two studies. Based on the data from two large cohort studies, we also found an increased risk of vitiligo in AD patients. This result further supports the association between AD and vitiligo.…”

Section: Discussionmentioning

confidence: 69%

“…The study selection process is summarized using the PRISMA flowchart in Figure . A total of seven studies (1 540 688 AD patients) were finally included in our study . Among these, five studies (137 846 AD patients) compared the prevalence of vitiligo in AD patients and controls, while two cohort studies (1 402 842 AD patients) reported the incidence of vitiligo in AD patients.…”

Section: Resultsmentioning

confidence: 99%

Association of atopic dermatitis with vitiligo: A systematic review and meta‐analysis

Acharya

Mathur

2019

J of Cosmetic Dermatology

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Background Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with multiple immune‐mediated disorders. A comprehensive meta‐analysis assessing the prevalence or risk of vitiligo in AD patients is lacking. Objective To compare the prevalence and assess the risk of vitiligo in patients with AD by performing a meta‐analysis of observational studies. Methods PubMed, Scopus, and Cochrane databases were systematically searched until August 25, 2019, following the PRISMA guidelines. Published English‐language articles including case‐control, cross‐sectional, or cohort studies that reported either odds or risk of vitiligo in AD patients were included. Full‐text review and study assessment were performed by the two authors independently. Random‐effects meta‐analysis model was used to calculate the odds ratio (OR) and risk ratio (RR) with the corresponding 95% confidence interval (CI). The risk of bias was assessed using the Newcastle‐Ottawa Scale. Results Seven studies with a total of 1 540 688 unique AD patients were included. The random‐effects meta‐analysis of case‐control and cross‐sectional studies showed a significant association of AD with vitiligo (OR, 3.21; 95% CI, 1.90‐5.43). Subgroup analyses also showed a significant association for both adult AD (OR, 4.46; 95% CI, 1.65‐12.07) and childhood AD (OR, 2.83; 95% CI, 1.53‐5.25). Pooling of the results of 2 cohort studies showed an increased risk of vitiligo in patients with AD (RR, 1.64; 95% CI, 1.27‐2.13). Conclusions Results from this study support an association of AD with vitiligo. Exploration of possible mechanisms responsible for this association could be important to develop proper treatment approaches for the affected patients.

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“…Recent epidemiologic studies have suggested that patients with AR may also have a higher risk of non‐IgE‐mediated autoimmune diseases, such as systemic lupus erythematosus, Sjogren syndrome, systemic sclerosis, and inflammatory bowel disease 9,10 . Several observational studies suggest an association between AR and risk of RA.…”

Section: Introductionmentioning

confidence: 99%

The association between allergic rhinitis and risk of rheumatoid arthritis: A systematic review and meta‐analysis

Charoenngam

Ponvilawan

Rittiphairoj

et al. 2020

J Evidence Based Medicine

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Objective To investigate the association between allergic rhinitis (AR) and the risk of rheumatoid arthritis (RA). Methods Potentially eligible studies were identified from MEDLINE and EMBASE databases from inception to November 2019. Eligible cohort study must report relative risk with 95% confidence intervals (95% CIs) of incident RA between AR patients and comparators. Eligible case‐control studies must include cases with RA and controls without RA, and must explore their history of AR. Odds ratio with 95% CIs of the association between AR and RA must be reported. Point estimates with standard errors from each study were combined using the generic inverse variance method. Results A total of 21,824 articles were identified. After two rounds of the independent review by three investigators, two cohort studies and 10 case–control studies met the eligibility criteria. The pooled analysis showed no association between AR and risk of RA (RR = 0.94; 95% CI, 0.73 to 1.20; I2 = 84%). However, when we conducted a sensitivity analysis including only studies with acceptable quality, defined as Newcastle‐Ottawa score of seven or higher, we found that patients with AR had a significantly higher risk of RA (RR = 1.36; 95% CI, 1.12 to 1.65; I2 = 45%). Conclusions The current systematic review and meta‐analysis could not reveal a significant association between AR and RA. However, when only studies with acceptable quality were included, a significantly higher risk of RA among patients with AR than individuals without AR was observed.

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Allergic diseases and long-term risk of autoimmune disorders: longitudinal cohort study and cluster analysis

Cited by 63 publications

References 36 publications

Allergic rhinitis and risk of systemic lupus erythematosus: A systematic review and meta‐analysis

Allergic rhinitis and risk of systemic lupus erythematosus: A systematic review and meta‐analysis

Association of atopic dermatitis with vitiligo: A systematic review and meta‐analysis

The association between allergic rhinitis and risk of rheumatoid arthritis: A systematic review and meta‐analysis

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