Allergic disease in infants up to 2 years of age in relation to plasma omega‐3 fatty acids and maternal fish oil supplementation in pregnancy and lactation

Furuhjelm, Catrin; Warstedt, Kristina; Fagerås, Malin; Fälth‐Magnusson, Karin; Larsson, Jan; Fredriksson, Mats; Duchén, Karel

doi:10.1111/j.1399-3038.2010.01096.x

Cited by 141 publications

(208 citation statements)

References 31 publications

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“…The overall incidence of IgEassociated disease at 6 years of age was higher than that reported in this cohort of children at 1 and 3 years of age 17,18 and other RCTs of prenatal n-3 LCPUFA supplementation for children at high hereditary risk of allergy 7,8,20 . This increased incidence is most likely due to the advancing age of the child when assessed and atopic march progression.…”

contrasting

confidence: 71%

“…15 Randomized controlled trials (RCTs) of n-3 LCPUFA supplementation during pregnancy have reported protective effects; however, apart from 1 16-year registry based follow-up, 16 all reported allergic disease outcomes are in early childhood (between 1 and 3 years of age). 7,8,[17][18][19][20] In addition, the small sample size of a number of RCTs 7,8,19,20 introduces bias and a degree of uncertainty regarding results. A recent systematic review evaluating the overall body of literature on the effects of n-3 LCPUFA intake during pregnancy concludes that further evidence from well-powered, high-quality trials are essential to establish benefits.…”

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confidence: 99%

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Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial

et al. 2016

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BACKGROUND AND OBJECTIVE: Evidence from randomized controlled trials in early infancy suggest that prenatal supplementation with Ω-3 (n-3) long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease characterized by an immunoglobulin E (IgE) response. We aimed to determine whether protective effects were evident in the 6-year-old offspring of women supplemented with n-3 rich fish oil during pregnancy.

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confidence: 71%

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confidence: 99%

Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial

et al. 2016

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“…В другом рандомизированном кон-тролируемом исследовании было показано, что даже такая небольшая дотация -3 ДПНЖК, как дополнитель-ный прием к основному рациону беременной женщины (с 20-й нед беременности и до родов) всего двух пор-ций лосося в нед (дотация -3 ПНЖК составляла около 3,45 г ЭПК и ДГК), статистически значимо меняла пока-затели иммунного ответа ребенка (цитокиновый про-филь пуповинной крови). Авторы не обнаружили досто-верной разницы между группами по общему уровню иммуноглобулина (Ig) E и частоте тяжелого атопического дерматита [52]. Однако, в другом рандомизированном исследовании, в котором беременные женщины из груп-пы риска получали 1,6 г ЭПК и 1,1 г ДГК или плацебо с 25-й нед беременности и до 3,5 мес в период лактации, был доказан их протективный эффект в отношении IgE-опосредованных аллергических заболеваний у детей до двухлетнего возраста.…”

Section: педиатрическая фармакологияunclassified

Long-Chain Polyunsaturated Ω-3 and Ω-6 Fatty Acids as Essential Nutrients in Different Periods of Childhood

Макарова¹,

Вишнева²

2014

Pediatr. farmakol.

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Длинноцепочечные полиненасыщенные жирные кислоты классов -3 и -6 как эссенциальный нутриент в разные периоды детства Адекватное питание подразумевает под собой доста-точное поступление всех макро-и микронутриентов, необходимое человеку в соответствии с его возрастом, физической активностью, функциональным состоянием всех органов и систем [1]. Систематические эпидемио-логические исследования состояния фактического пита-ния и здоровья взрослых и детей в различных регионах России, проводимые НИИ питания РАМН, у большей части населения выявляют нарушения пищевого ста-туса, наиболее распространенными из которых явля-ются дефицит животных белков, достигающий 15-20% от рекомендуемых величин; дефицит полиненасыщен-ных жирных кислот на фоне избыточного поступле-ния животных жиров; дефицит большинства витами-нов, обнаруживаемый повсеместно и круглогодично у большей части населения [2][3][4]. Проведенные в ФГБУ «НЦЗД» РАМН исследования фактического питания детей и подростков, занимающихся спортом, показали,

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“…The few studies specifically addressing the preventive effect of n-3 PUFA supplementation of pregnant women on children at risk of food allergies, summarized in table 2, have not yet confirmed their beneficial role as a strategy for the primary prevention of food allergy [54][55][56][57][58].…”

Section: Clinical Studiesmentioning

confidence: 99%

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

Luengo¹,

Song²

2013

J Aller Ther

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Effective primary preventions strategies aimed at reducing the onset of IgE sensitization are urgently needed as the incidence of childhood food allergy keeps increasing.Studies eliminating food allergens during pregnancy have failed to show reduction in the prevalence of long-term IgE-mediated food allergy in children, and recent data provides direct evidence supporting early oral exposure as a means of preventing development of allergy. Since effects on early immune programming may be more significant in utero, there has been increasing interest in the potential protective role of maternal dietary modifications on the development of FA in offspring.In this article, we will review the current knowledge from animal and clinical studies on the role of maternal dietary modification, mainly through supplementation with vitamins, polyunsaturated fatty acids and probiotics, for the prevention of food allergy. Besides, the potential role of some promising FA treatments like Chinese herbal formula FAHF-2 for the primary prevention of FA in offspring will be reviewed. be due to uncontrolled environmental factors, timing of introduction to PN and different study protocols and populations, as well as undefined co-factors in maternal diet such as microbes [18][19][20]. In addition, retrospective maternal recall of dietary intake during pregnancy (and or lactation), sometimes months or years later, may contain recall bias. At present, the standard practice for PNA and other food allergies is strict allergen avoidance. There is no clinical study reporting whether peanut allergic mother consumption of controlled low doses of peanut that do not trigger clinical reactions would prevent offspring peanut or other food allergies. The Potential of Maternal Dietary Modification for Prevention of Food AllergyOlga Maternal allergenic food consumption for preventing food allergy in offspring: Animal studiesIn recent years several studies in animal models have provided direct evidence supporting early oral exposure as a means of preventing development of allergy.Melkild et al. [21] showed that intraperitoneal immunization of naïve mice with ovalbumin and adjuvant (Al(OH) 3 ) during pregnancy and lactation significantly reduced the specific IgE response and increased the IgG2a response in their offspring. Moreover, the IgE suppression was stronger if maternal allergen exposure was during early pregnancy (3 days into pregnancy) compared to a late pregnancy exposure (17 days into pregnancy). The same group reported that the protective effect of maternal immunization was affected by the type of adjuvant used: while offspring from mothers immunized with OVA and either pertussis toxin (PT) or Al(OH) 3 showed reduced levels of OVA-specific IgE and IgG1 and increased levels of OVA-specific IgG2a antibodies, maternal immunization with CpG and OVA did not affect antibody responses in offspring [22]. However, whether this effect is dependent on the specific adjuvant and/or the route of exposure employed has to be further investigated. Le...

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Allergic disease in infants up to 2 years of age in relation to plasma omega‐3 fatty acids and maternal fish oil supplementation in pregnancy and lactation

Cited by 141 publications

References 31 publications

Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial

Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial

Long-Chain Polyunsaturated Ω-3 and Ω-6 Fatty Acids as Essential Nutrients in Different Periods of Childhood

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

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