Allergic Disease at the Age of 7 Years After Pertussis Vaccination in Infancy

Nilsson, Lennart; Kjellman, N.‐I. M.; Björkstén, Bengt

doi:10.1001/archpedi.157.12.1184

Cited by 55 publications

(6 citation statements)

References 29 publications

(49 reference statements)

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“…The studies conducted that way yielded inconsistent results. Our results are consistent with the observations of other authors who did not confirm the influence of DTwP exposure on the development of allergy [ 11 , 15 , 16 ]. Some of them even observed the protective effect of DTwP vaccination with respect to the onset of asthma and other allergic diseases in later life [ 17 – 19 ].…”

Section: Discussionsupporting

confidence: 94%

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Whole-cell pertussis vaccine (DTwP) has no influence on allergic diseases and atopic sensitization in children

Mrozek-Budzyn

Majewska

Kiełtyka

et al. 2018

pdia

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IntroductionVaccine opponents indicate that the infant’s immune system is inadequately developed to handle multiple vaccines which may overwhelm the immune system, leading to allergic diseases.AimTo verify the association between the vaccine antigen overload derived from DTwP and the development of atopic sensitization and allergic diseases.Material and methodsData from an earlier established birth cohort in Krakow, followed up to the 6th year of life were used. Allergic diseases such as eczema, hay fever and asthma were diagnosed by a physician and reported every half a year from the 1st to 6th year of life by the child’s parent. Skin prick tests (SPT) were performed in children at 5 years of age. The data on infants’ vaccination were extracted from the physician’s records. The status of vaccine antigen exposure was based on different types of vaccines against pertussis (DTwP or DTaP) in a primary course. Results were determined by multiple logistic regression, adjusted to potential confounders.ResultsThe analyzed population consisted of 234 children: 53.4% – boys and 46.6% – girls. Infants up to the age of 8 months were vaccinated with the primary course against pertussis, with DTwP – 60.7%, DTaP – 32.9% and further 6.4% with a mixed course (DTwP + DTaP). There were no significant relationships between any of vaccination groups and allergic disease and allergen sensitivity in the multiple logistic regression model with adjustment to potential confounders.ConclusionsThe exposure to a large number of vaccine antigens derived from DTwP has no influence on the development of allergic diseases and atopic sensitization in children.

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Section: Discussionsupporting

confidence: 94%

“…Hence, unvaccinated children are a highly selected and usually atypical group. It is related to studies on DTwP as well [ 11 – 14 ].…”

Section: Discussionmentioning

confidence: 99%

Whole-cell pertussis vaccine (DTwP) has no influence on allergic diseases and atopic sensitization in children

Mrozek-Budzyn

Majewska

Kiełtyka

et al. 2018

pdia

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“…A reported sequela of Bordetella spp. infections is the increased risk for asthma and allergies [ 84 , 85 , 86 ], which suggests that bacteria trigger this hyper-reactive eosinophilic state. However, recent literature has revealed that B. bronchiseptica can suppress eosinophil influx in the lungs to promote bacterial persistence [ 87 ], suggesting that eosinophils, in fact, actively participate in the immune responses to Bordetella spp.…”

Section: Eosinophils and Innate Immunitymentioning

confidence: 99%

Eosinophils and Bacteria, the Beginning of a Story

Ondari

Calvino-Sanles

First

et al. 2021

IJMS

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Eosinophils are granulocytes primarily associated with TH2 responses to parasites or immune hyper-reactive states, such as asthma, allergies, or eosinophilic esophagitis. However, it does not make sense from an evolutionary standpoint to maintain a cell type that is only specific for parasitic infections and that otherwise is somehow harmful to the host. In recent years, there has been a shift in the perception of these cells. Eosinophils have recently been recognized as regulators of immune homeostasis and suppressors of over-reactive pro-inflammatory responses by secreting specific molecules that dampen the immune response. Their role during parasitic infections has been well investigated, and their versatility during immune responses to helminths includes antigen presentation as well as modulation of T cell responses. Although it is known that eosinophils can present antigens during viral infections, there are still many mechanistic aspects of the involvement of eosinophils during viral infections that remain to be elucidated. However, are eosinophils able to respond to bacterial infections? Recent literature indicates that Helicobacter pylori triggers TH2 responses mediated by eosinophils; this promotes anti-inflammatory responses that might be involved in the long-term persistent infection caused by this pathogen. Apparently and on the contrary, in the respiratory tract, eosinophils promote TH17 pro-inflammatory responses during Bordetella bronchiseptica infection, and they are, in fact, critical for early clearance of bacteria from the respiratory tract. However, eosinophils are also intertwined with microbiota, and up to now, it is not clear if microbiota regulates eosinophils or vice versa, or how this connection influences immune responses. In this review, we highlight the current knowledge of eosinophils as regulators of pro and anti-inflammatory responses in the context of both infection and naïve conditions. We propose questions and future directions that might open novel research avenues in the future.

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“…Atopic disease usually develops in the early life of children, whose immune system is under development [9]. ere is evidence revealing the relationship between vaccination and the risk of atopic disease [10], and many publications have investigated this hypothesis [11][12][13][14][15]. Among those relationships, the most investigated one is the relationship between BCG vaccine and atopic disease, but the results remain controversial.…”

Section: Introductionmentioning

confidence: 99%

BCG Vaccination in Early Childhood and Risk of Atopic Disease: A Systematic Review and Meta-Analysis

Zhao

Miles

Jiang

et al. 2021

Canadian Respiratory Journal

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Background. Several large-scale studies suggest that Bacille Calmette–Guerin (BCG) vaccination in early childhood may reduce the risk of atopic diseases, but the findings remain controversial. Here, we aimed to investigate the potential correlation between early childhood BCG vaccination and the risk of developing atopic diseases. Methods. Eligible studies published on PubMed, EMBASE, and Cochrane CENTRAL were systematically sourced from 1950 to July 2021. Studies with over 100 participants and focusing on the association between BCG vaccine and atopic diseases including eczema, asthma, and rhinitis were included. Preliminary assessment of methods, interventions, outcomes, and study quality was performed by two independent investigators. Odds ratio (OR) with 95% confidence interval (CI) was calculated. Random effects of the meta-analysis were performed to define pooled estimates of the effects. Results. Twenty studies with a total of 222,928 participants were selected. The quantitative analysis revealed that administering BCG vaccine in early childhood reduced the risk of developing asthma significantly (OR 0.77, 95% CI 0.63 to 0.93), indicating a protective efficacy of 23% against asthma development among vaccinated children. However, early administration of BCG vaccine did not significantly reduce the risk of developing eczema (OR 0.94, 95% CI 0.76 to 1.16) and rhinitis (OR 0.99, 95% CI 0.81 to 1.21). Further analysis revealed that the effect of BCG vaccination on asthma prevalence was significant especially in developed countries (OR 0.73, 95% CI 0.58 to 0.92). Conclusion. BCG vaccination in early childhood is associated with reduced risk of atopic disease, especially in developed countries.

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Allergic Disease at the Age of 7 Years After Pertussis Vaccination in Infancy

Abstract: Pertussis vaccination in infancy with any of these vaccines was not associated with allergic manifestations at the age of 7 years, apart from a higher prevalence of positive skin prick test results after an experimental 2-component vaccine, which is no longer in use.

Cited by 55 publications

References 29 publications

Whole-cell pertussis vaccine (DTwP) has no influence on allergic diseases and atopic sensitization in children

Whole-cell pertussis vaccine (DTwP) has no influence on allergic diseases and atopic sensitization in children

Eosinophils and Bacteria, the Beginning of a Story

BCG Vaccination in Early Childhood and Risk of Atopic Disease: A Systematic Review and Meta-Analysis

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