Allergic Contact Dermatitis to Nickel Is Characterized by a Specific Micro-RNA Signature

Løvendorf, Marianne B.; Dyring‐Andersen, Beatrice; Vennegaard, Marie T.; Clemmensen, Anders; Bonefeld, Charlotte M.; Røpke, Mads A.; Skov, Lone

doi:10.1097/der.0000000000000127

Cited by 3 publications

(4 citation statements)

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“…Lukas Wisgrill 1,2 Matilda Riskumäki 1 Erja Jalonen 3 Johanna Vendelin 4 Sari Suomela 4 Antti Lauerma 3 Harri Alenius 1,5 Nanna Fyhrquist 1,5…”

Section: Ack N Owled G Em Entsunclassified

“…1 miRNAs are short single-stranded RNA molecules, which take part in the post-transcriptional regulation. 1 Most previously conducted studies have focused on changes in miRNA expression profiles [1][2][3] ; however, their regulatory effects as well as changes in the miRNAome in response to contact sensitizers and irritants with different physiochemical properties needs elucidation.…”

Section: Identification Of Novel Mirna-mrna Regulatory Network In Contact Dermatitis By Integrated Microarray Analysismentioning

confidence: 99%

“…1 Histamine mediates its effects via four different G-protein coupled receptors (H 1 R-H 4 R), which are widely expressed on various immune cells and keratinocytes. 2 In recent years, many studies in particular focussed on the H 4 R, which became a promising target in the therapy of AD. 1 It has been reported that eosinophils express a functional H 4 R and that it is involved in chemotaxis, calcium influx, as well as in shape change.S1 -S4 This study aimed to examine the expression pattern and regulation of histamine receptors on eosinophils under Th2 conditions and to investigate possible immunomodulatory functions especially of the H 4 R. For this purpose, we isolated human eosinophils from peripheral blood via density centrifugation and negative bead selection (for details see Appendix S1).…”

Section: O Rci Dmentioning

confidence: 99%

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Identification of novel miRNA‐mRNA regulatory networks in contact dermatitis by integrated microarray analysis

Werner

Wisgrill

Riskumäki

et al. 2020

Allergy

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“…Lukas Wisgrill 1,2 Matilda Riskumäki 1 Erja Jalonen 3 Johanna Vendelin 4 Sari Suomela 4 Antti Lauerma 3 Harri Alenius 1,5 Nanna Fyhrquist 1,5…”

Section: Ack N Owled G Em Entsunclassified

Section: Identification Of Novel Mirna-mrna Regulatory Network In Contact Dermatitis By Integrated Microarray Analysismentioning

confidence: 99%

Section: O Rci Dmentioning

confidence: 99%

See 1 more Smart Citation

Identification of novel miRNA‐mRNA regulatory networks in contact dermatitis by integrated microarray analysis

Werner

Wisgrill

Riskumäki

et al. 2020

Allergy

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“…Профессиональные заболевания тесно связаны с экономическими затратами и являются предиктором безработицы, приводя к потере трудоспособности и необходимости смены рабочих мест [2]. Так, исследователи из США указывают, что заболевания, связанные с работой, несут убытки как работодателя, так и работника и обусловливают до 25% всех случаев нетрудоспособности [3][4][5].…”

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Modern Approach to the Diagnosis of Occupational Skin Diseases in Workers of Industrial Enterprises of the Sverdlovsk Region

Уфимцева¹,

Nikolaeva²,

Beresneva³

et al. 2021

СПНО (MPSE)

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Профессиональный дерматозгруппа поражений кожи, вызванных воздействием одного или нескольких производственных факторов. Согласно оценкам экспертов, заболеваемость аллергодерматозами в РФ превышает декларированную в связи с трудностями в проведении диагностики и несовершенством проведения медицинских осмотров. Кроме того, страх потерять работу приводит к сокрытию пациентами имеющихся у них заболеваний при прохождении медицинских осмотров, в том числе к отсутствию жалоб, использованию медикаментов перед осмотром, отказу от своевременного проведения лечебнопрофилактических и реабилитационных мероприятий. В статистике профессиональных заболеваний кожи в настоящий момент превалируют контактные дерматиты с преимущественным поражением кистей рук. Особенно актуальным для Российской Федерации является наличие профессионального поражения кожи у промышленников, в частности металлургов. В статье рассмотрены основные принципы диагностики профессиональных заболеваний кожи, в частности аллергического дерматита, маршрутизация пациентов с подозрением на них и трудности в диагностике. Раннее и эффективное выявление профессионального дерматита при взаимодействии дерматовенеролога и профпатолога позволяет сохранить трудоспособность работника и предупредить развитие стойких поражений кожи с выраженным снижением качества жизни. Ключевые слова: профессиональный дерматоз, профессиональный аллергический дерматит, периодический медицинский осмотр.

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Identification of microRNA Signatures in Peripheral Blood of Young Women as Potential Biomarkers for Metal Allergy

et al. 2023

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MicroRNA (miRNA) is a short (19–24 nucleotide) endogenous non-protein RNA that exists in the body and controls the translation process from genes to proteins. It has become useful as a diagnostic tool and a potential treatment target in cancer research. To explore the function of miRNA in contact dermatitis, female participants with a positive metal allergy diagnosis (n = 3) were enrolled along with additional female participants with no medical history of metal allergy (n = 3). A patch test was performed on each participant. Peripheral blood was collected from all the participants before the patch test and at days 3 and 7 after starting the patch test. After total RNA was obtained from peripheral blood leukocytes and cDNA was generated, microarray analysis was performed to analyze the large-scale circulating miRNA profile. Real-time polymerase chain reaction (RT-PCR) was then used to clarify the overall target miRNA expression. Downregulation of hsa-let-7d-5p, hsa-miR-24-3p, hsa-miR-23b-3p, hsa-miR-26b-5p, and hsa-miR-150-5p was found on day 7. Certain miRNAs were confirmed using RT-PCR. These peripheral blood miRNAs could be diagnostic biomarkers for metal allergies.

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Allergic Contact Dermatitis to Nickel Is Characterized by a Specific Micro-RNA Signature

Cited by 3 publications

References 1 publication

Identification of novel miRNA‐mRNA regulatory networks in contact dermatitis by integrated microarray analysis

Identification of novel miRNA‐mRNA regulatory networks in contact dermatitis by integrated microarray analysis

Modern Approach to the Diagnosis of Occupational Skin Diseases in Workers of Industrial Enterprises of the Sverdlovsk Region

Identification of microRNA Signatures in Peripheral Blood of Young Women as Potential Biomarkers for Metal Allergy

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