“…A wide variety of topical ophthalmics are contact sensitizers (1,2), including epinephrine hydrochloride (3)(4)(5). The development of dipivalyl epinephrine (dipivefrine), synthesised by the addition of 2 pivalic acid groups to epinephrine, results in a more lipophilic compound with greater penetration of the corneal layer and a lower incidence of side-effects than epinephrine, but with similar mydriatic effect on glaucoma (6,7).…”