Allergic Contact Dermatitis to Epinephrine

Gibbs, Richard C.

doi:10.1001/archderm.1970.04000010094017

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1976

1998

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Cited by 12 publications

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“…A wide variety of topical ophthalmics are contact sensitizers (1,2), including epinephrine hydrochloride (3)(4)(5). The development of dipivalyl epinephrine (dipivefrine), synthesised by the addition of 2 pivalic acid groups to epinephrine, results in a more lipophilic compound with greater penetration of the corneal layer and a lower incidence of side-effects than epinephrine, but with similar mydriatic effect on glaucoma (6,7).…”

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confidence: 99%