Allergic contact dermatitis to drometrizole trisiloxane in a woman thereafter diagnosed with frontal fibrosing alopecia

Pastor‐Nieto, María‐Antonia; Gática‐Ortega, María Elena

doi:10.1111/cod.14370

Cited by 3 publications

(15 citation statements)

References 10 publications

(13 reference statements)

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“…Two prior investigations involving 5% and 2% pet. concentrations on D7 and D6, respectively, had previously been negative 13 . We believe concentrations of EHS higher than commercially available may possibly be needed in order to identify the EHS sensitisation.…”

Section: Discussionmentioning

confidence: 89%

“…Twelve cases of sensitisation to EHS were identified in 10 articles published from 2004 to 2023 8,10,13,17,21–26 (Table S2) across Europe and in the USA. Sex was not specified in two cases and the remaining 10 cases involved women.…”

Section: Resultsmentioning

confidence: 99%

“…Three patients had FFA 8,10,13 . One of them, initially presented with facial ADMH, and was, subsequently, diagnosed with FFA and ACD 10 …”

Section: Resultsmentioning

confidence: 99%

“…Case reports of relevant sensitisation to emerging allergens in cosmetics involving patients with FFA have recently been published, such as facial allergic contact dermatitis (ACD) from Magnolia officinalis bark extract and ethylhexyl salicylate (EHS) involving one patient with FFA and lichen planus pigmentosus 10 ; ACD to shellac in a hair spray in one patient with FFA 11 ; one case of ACD to diethylamino hydroxybenzoyl hexyl benzoate in a sunscreen, as well as cinnamal and cinnamyl alcohol in a facial moisturiser, involving one patient with acquired dermal macular hyperpigmentation (ADMH), subsequently diagnosed with FFA 12 ; and, ACD to drometrizole trisiloxane and EHS in a woman, eventually diagnosed with FFA. 13 2-EHS (IUPAC name: 2-ethylhexyl 2-hydroxybenzoate; molecular formula: C 15 H 22 O 3 ; CAS no. 118-60-5; syn.…”

mentioning

confidence: 99%

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Sensitisation to ethylhexyl salicylate: Another piece of the frontal fibrosing alopecia puzzle

Pastor‐Nieto,

Gatica‐Ortega,

Borrego

2023

Contact Dermatitis

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BackgroundThere is speculation that some environmental factors may be impacting the increasing incidence of frontal fibrosing alopecia (FFA). In a recent publication, sensitisation to benzyl salicylate was shown to be prevalent among 36 patients with FFA. Ethylhexyl salicylate (EHS), a light stabiliser, ultraviolet (UV) B absorber and UV filter, frequently found in photoprotectors/cosmetics and, rarely reported as a sensitiser, was not patch tested in said research.MethodsFrom January 2021 to February 2022, 33 patients with FFA were patch‐tested with the European Photopatch Series, including EHS 10% pet. in two hospitals. In addition, we conducted a literature review and a market survey.ResultsPatch test reactions to EHS were identified in 9 of 33 (27.3%). Four of nine also reacted to their personal sunscreens (containing EHS). All involved women with a mean age of 54 (30–65). Five patients had been diagnosed with FFA before the patch tests; and, four were diagnosed with FFA during the patch test investigations.ConclusionSensitisation to EHS was frequently found in a selected population of patients with FFA. We propose to expand the spectrum of contact allergens described in patients with FFA to include EHS and discuss the possible need for optimization of the patch test preparation.

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Section: Discussionmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

“…Three patients had FFA 8,10,13 . One of them, initially presented with facial ADMH, and was, subsequently, diagnosed with FFA and ACD 10 …”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Sensitisation to ethylhexyl salicylate: Another piece of the frontal fibrosing alopecia puzzle

Pastor‐Nieto,

Gatica‐Ortega,

Borrego

2023

Contact Dermatitis

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“…Dyes, hairsprays, and other hair cosmetics contain ingredients with a high sensitization potential. The most prominent allergens are ethylhexyl salicylate [72], drometrizole trisiloxane [73], diethylamino hydroxybenzoyl hexyl benzoate [74], and benzyl salicylate [75]. This topic is controversial.…”

Section: Frontal Fibrosing Alopecia and Acdmentioning

confidence: 99%

Contact Dermatitis Due to Hair Care Products: A Comprehensive Review

Cebolla-Verdugo,

Velasco-Amador,

Navarro-Triviño

2024

Cosmetics

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Hair cosmetics are in fashion. Numerous products are commonly used in combination. Frequent allergens are present in hair cosmetics, which, with almost daily use, increase the risk of sensitization. Familiarity with the clinical distribution of the eczematous rash is necessary to seriously consider patch testing. Not all the products on the market are haptens. It is necessary to know how to patch your own products. When avoidance of the allergen is not possible, new treatments are evaluated to combat allergic contact dermatitis, mainly of the occupational type. In this manuscript, a complete and practical review of the main allergens and contact sources of hair cosmetic origin has been carried out.

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Tangled Truths: Unraveling the Link Between Frontal Fibrosing Alopecia and Allergic Contact Dermatitis

George

2024

Cutis

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Allergic contact dermatitis to drometrizole trisiloxane in a woman thereafter diagnosed with frontal fibrosing alopecia

Cited by 3 publications

References 10 publications

Sensitisation to ethylhexyl salicylate: Another piece of the frontal fibrosing alopecia puzzle

Sensitisation to ethylhexyl salicylate: Another piece of the frontal fibrosing alopecia puzzle

Contact Dermatitis Due to Hair Care Products: A Comprehensive Review

Tangled Truths: Unraveling the Link Between Frontal Fibrosing Alopecia and Allergic Contact Dermatitis

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