Allergic Contact Dermatitis Secondary to Moisturizers

Abstract

Background: Moisturizers are cosmetic products used routinely to manage various skin conditions. Even though moisturizers are often thought to have minimal or no adverse reactions, allergic contact dermatitis (ACD) to these products can develop in some cases. Methods: We studied ingredients included in 3 of the most commonly used moisturizer brands, identified their presence in standard patch testing series, and evaluated their allergenic potential, categorizing the allergens as frequent or infrequent. The standard patch testing series used as reference were the Thin-layer Rapid Use Epicutaneous patch test (T.R.U.E. test), the North American Contact Dermatitis Group (NACDG) screening standard series, and the American Contact Dermatitis Society (ACDS) core allergen series. Results: Aveeno, Cetaphil, and Cerave products had a total of 12, 14, and 9 potential allergens, respectively, the majority of which were infrequent and not included in standard patch testing series. Conclusion: Being aware of the allergenic potential of commonly used moisturizers may help healthcare providers when evaluating patients with ACD. Further testing is recommended in a targeted manner when suspecting ACD with negative standard patch testing series or when ACD is refractory to treatment.

Multiple topical product dermatitis: Paradigms in understanding and future perspectives

“…20 It has been highlighted that ACD may commonly arise even when patients and consumers use products that are labelled as suitable for sensitive skin. 21 As highlighted previously 22 people use multiple products daily, some of which are mild irritants and may not be detected in patch testing. Furthermore, not all products identified as irritants will affect everyone in the same way.…”

“…Haircare products are also a common source of dermatitis with one study reporting 9.0% of patients ( n = 38,775) having a positive patch test associated with these products 20 . It has been highlighted that ACD may commonly arise even when patients and consumers use products that are labelled as suitable for sensitive skin 21 …”