Allergic contact dermatitis induces upregulation of identical microRNAs in humans and mice

Vennegaard, Marie T.; Bonefeld, Charlotte M.; Hagedorn, Peter; Bangsgaard, Nannie; Løvendorf, Marianne B.; Ødum, Niels; Woetmann, Anders; Geisler, Carsten; Skov, Lone

doi:10.1111/j.1600-0536.2012.02083.x

Cited by 72 publications

(67 citation statements)

References 20 publications

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“…These authors later reported increased T H 1 polarization in mice lacking miR-21 (Lu et al, 2011). Increases in expression of miR-21 in both human and mouse skin samples following sensitization and challenge with the chemical sensitizer diphenylcyclopropenone has also been identified (Vennegaard et al, 2012). Using peripheral blood samples of patients with allergic asthma, research investigating the role of miR-155 in allergic disease suggests that over-expression promotes CD4 þ T-cells to differentiate to T H 1 cells while lower expression promotes a T H 2 response (Zhang et al, 2012).…”

Section: Discussionmentioning

confidence: 94%

“…The central importance of miRNA regulation in cellular function is becoming clearer as more miRNA targets are discovered. While information regarding roles of miRNA in chemical sensitization are limited, recent research suggests involvement of miRNA in both chemical-induced contact hypersensitivity and asthma (Lu & Rothenberg, 2013;Vennegaard et al, 2012;Zhang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization

Anderson

Beezhold

Lukomska

et al. 2013

Journal of Immunotoxicology

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Allergic disease is an important occupational health concern, with work-related asthma and allergic contact dermatitis being the most frequently diagnosed occupational illnesses. Diisocyanates, particularly toluene 2,4-diisocyanate (TDI), have been the leading cause of occupational asthma for many years. Understanding the mechanisms behind allergic disease is critical for treatment and prevention. Recently, the study of post-transcriptional regulation by microRNAs (miRNA) has shed light on mechanisms of allergic disease. The present studies report the expression of miRNA during the sensitization phase of an allergic response to TDI in a murine model. Female BALB/c mice were dermally exposed to TDI (0.1-15% [v/v]) or vehicle. RNA was isolated from superficial parotid lymph nodes at timepoints between 1 h and 15 days post-exposure and then miRNA expression was analyzed using array and real-time quantitative PCR analysis. Consistent changes in miRNA expression were identified for miR-21, miR-22, miR-27b, miR-31, miR-126, miR-155, miR-210, and miR-301a. Following TDI exposure, peak expression was observed by Day 4 for the majority of miRNA evaluated with trends in expression correlated to exposure concentration. Confirmed and predicted targets were identified using Diana-microT, miRanda, miRwalk, and Targetscan algorithms. Evaluation of mRNA expression of cytokine and transcription factor targets suggests that miRNA may have a central role early in TDI sensitization. Understanding the role of these miRNA and their specific mechanism of action in sensitization to TDI may provide pertinent information for the identification of other chemical sensitizers while also contributing to the treatment and prevention of allergic disease.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization

Anderson

Beezhold

Lukomska

et al. 2013

Journal of Immunotoxicology

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show abstract

“…MiR-21 suppresses TLR2 signaling, and IL-13 can upregulate miR-21 expression in human airway epithelial cells [53]. The upregulation of miR-21, miR-142-3p, miR-142-5p, and miR-223 was observed both in human and mouse allergic contact dermatitis [54]. Esophageal miRNA expression profile was investigated by microarray from human esophageal tissues of eosinophilic esophagitis (EoE) patients and controls, where the most upregulated miRNAs were miR-21 and miR-223, and the most downregulated one was miR-375.…”

Section: Further Myeloid Mirnas With Well Characterized Effectsmentioning

confidence: 99%

Myeloid-Derived microRNAs, miR-223, miR27a, and miR-652, Are Dominant Players in Myeloid Regulation

Gilicze

Wiener

Tóth

et al. 2014

BioMed Research International

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In the past few years expanding knowledge has been accumulated about the role of microRNAs (miRNAs) not only in hematopoiesis and cancer, but also in inflammatory and infectious diseases. Regarding myeloid cells, our knowledge is relatively insufficient, therefore we intended to collect the available data of miRNA profiles of myeloid cells. In addition to a rather general myeloid regulator miR-223, two other miRNAs seem to be useful subjects in understanding of myeloid miRNA biology: miR-27a and miR-652. We review functions of these three miRNAs and other myeloid miRNAs focusing on their roles in monocytes, neutrophils, eosinophils, basophils and mast cells.

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“…87 Notably, miRNAs upregulated in other allergic disorders, including miR-21, miR-146, and miR-223, are also upregulated in the skin of patients with atopic dermatitis. 42,88 In addition, Sonkoly et al found that miR-155 was one of the highest upregulated miRNAs in skin biopsies from patients with atopic dermatitis compared to healthy controls. 79 Topical exposure of non-lesional skin of atopic dermatitis patients with relevant allergens could induce miR-155 expression.…”

Section: Atopic Dermatitismentioning

confidence: 99%

Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

2013

Journal of Allergy and Clinical Immunology

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Allergic inflammation is accompanied by the coordinated expression of a myriad of genes and proteins that initiate, sustain, and propagate immune responses and tissue remodeling. MicroRNAs (miRNAs) are a class of short single-stranded RNA molecules that post-transcriptionally silence gene expression and have been shown to fine-tune gene transcriptional networks as single miRNAs can target hundreds of genes. 7 Considerable attention has focused on the key role of miRNAs in regulating homeostatic immune architecture and acquired immunity. Recent studies have identified miRNA profiles in multiple allergic inflammatory diseases including asthma, eosinophilic esophagitis, allergic rhinitis, and atopic dermatitis. Specific miRNAs have been found to have critical roles in regulating key pathogenic mechanisms in allergic inflammation including polarization of adaptive immune responses and activation of T cells (e.g. miR-21 and miR-146), regulation of eosinophil development (e.g. miR-21 and miR-223), and modulation of interleukin (IL)-13-driven epithelial responses (e.g. miR-375). This review discusses recent advances in our understanding of the expression and function of miRNAs in allergic inflammation, their role as disease biomarkers, and perspectives for future investigation and clinical utility.

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Allergic contact dermatitis induces upregulation of identical microRNAs in humans and mice

Abstract: These are the first results indicating that microRNAs may be involved in the pathogenesis of allergic contact dermatitis, and they show that mouse models are valuable tools for further study of the involvement of microRNAs in allergic contact dermatitis.

Cited by 72 publications

References 20 publications

Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization

Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization

Myeloid-Derived microRNAs, miR-223, miR27a, and miR-652, Are Dominant Players in Myeloid Regulation

Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

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