Allergic contact dermatitis from Solvent Orange 60 in spectacle frames

Abstract

Potential allergens in plastic spectacle frames concern plasticizers, antioxidants, UV filters, and dyes. Among the latter, Solvent Orange 60 (SO 60) has been recognized as an important allergen, and presently 32 cases have been reported in Japan and Scandinavia. In Japan, the first case of allergic contact dermatitis (ACD) from SO 60 in spectacle frames was reported in 1999, and 17 similar cases followed until 2018. Since 2006, 14 cases, observed among plastic production workers, and spectacle and dental goggle users, were reported in Scandinavia. This review provides a summary of the 18 Japanese cases of ACD from SO 60, the clinical manifestations, diagnostic method and results, provenance of causative spectacle plastic plates, as well as some countermeasures to prevent contact allergy to it.

Presence of Solvent Orange 60 and Solvent Red 179 in Eyeglass Frames and Temple Tips in Japan

“…Solvent Orange 60 elicited a strong positive reaction (a positive reaction confirmed at 0.001% petrolatum), 3 and the use of SO60 in eyeglass frames and temple tips has been avoided by Japanese manufacturers. However, recently, ACD due to SO60 in eyeglass frames and temple tips has been increasing again 1 . Thus, we surveyed presence of SO60 in eyeglass frames and temple tips that could be purchased in Japan.…”

“…Because Solvent Red 179 (SR179; Fig. 1B), a solvent dye, has been reported to cross-react with SO60 and be used in eyeglass frames, it was also surveyed 1 …”

“…Allergic contact dermatitis (ACD) caused by Solvent Orange 60 (SO60; Fig. 1A), a perinone-type dye found in the plastic frames and temple tips of eyeglasses, goggles, and other articles, has been reported in Japan and Northern Europe 1,2 . Solvent Orange 60 elicited a strong positive reaction (a positive reaction confirmed at 0.001% petrolatum), 3 and the use of SO60 in eyeglass frames and temple tips has been avoided by Japanese manufacturers.…”