Allergic contact dermatitis from pyoctanin

Abstract

Although pyoctanin is widely used in medicine, there are hardly any reports of contact allergy to it. Most reports of side-effects refer to irritant reactions after topical application. We describe 2 patients who developed pyoctanin contact dermatitis after long-term application on damaged skin. Positive patch test results down to concentrations of 0.0025% and 0.05% aqueous pyoctanin solution, respectively, were found.

Two-Dimensional Cellular and Three-Dimensional Bio-Printed Skin Models to Screen Topical-Use Compounds for Irritation Potential

“…It is also used in agriculture as a soil fungicide, plant bactericide, and acaricide (Fiege et al, 2000). Studies have shown that some patients tested with a concentration range of 0.3% to 6% transdermal patches (7-147 µM) were allergic to this substance (Schoppelrey et al, 1997). At a high concentration (200 µM), hexachlorophene dramatically increased the IL-1α secretion in the RhE and FTS models ( Figure 4A).…”