Allergic contact dermatitis from hydroxyacetophenone in an anti‐wrinkle facial serum with flare‐up reactions triggered by the repeated open application test

Abstract

ACD related to the use of metronidazole intravaginal ovules, which was characterized by a symmetrical drug-related intertriginous and flexural exanthema pattern. 6 Cases of ACD in patients using metronidazole gel or cream for rosacea have been described. 7,8 Metronidazole is a nitroimidazole with structural similarities to other imidazole derivatives. A case of cross-reactivity between metronidazole and bifonazole and tioconazole has been described. 9 In other reports, 7,8 patch testing in patients with ACD to metronidazole did not disclose cross-reactions with other imidazoles. Corazza et al. described a patient with vulvovaginal ACD to clotrimazole who had negative patch test reactions to miconazole, metronidazole, and isothiazolinones. 5 A possible cross-reaction between imidazoles and isothiazolinones has also been hypothesized. 10 The diagnosis of iatrogenic ACD should be considered in patients with genital dermatoses and/or symptoms that worse during treatment with topical drugs. We emphasize the importance of performing patch tests with patient's own products in such circumstances.

Contact allergy to resacetophenone

“…9 Contact allergy has been reported due to its presence in a face cream 10 and antiwrinkle serum. 11 Resacetophenone (2 0 ,4 0 -dihydroxyacetophenone) is found in the plant Vincetoxicum atratum (swallow wort) and Cynanchum wilfordii and is used as an antioxidant, bleach and skin conditioning ingredient.…”

“…It is also used as a preservative and antioxidant in cosmetics and pharmaceuticals 9 . Contact allergy has been reported due to its presence in a face cream 10 and antiwrinkle serum 11 …”