Allergic contact dermatitis from gentamicin in eyedrops, with cross‐reactivity to kanamycin but not neomycin

Sánchez‐Pérez, Javier; López, Marta Pascual; Haro, María José Moreno De Vega; García‐Diez, Amaro

doi:10.1034/j.1600-0536.2001.440107-21.x

Cited by 25 publications

(6 citation statements)

References 1 publication

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“…It also contains boric acid, sodium borate, chlorobutanol, povidone and polysorbate 80. Representative causative agents for ACD due to eye drops include drugs for glaucoma, 4–6 antibiotics, 7 antihistamines or anti‐allergic drugs, 8–12 steroids, 13 eye drops for keratoconjunctival epithelial damage (e.g. hyaluronate sodium ophthalmic solution) 14 , mydriatic eye drops for examination 15 and additives or preservatives 16,17 .…”

Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis due to diclofenac sodium in eye drops

Miyazato

Yamaguchi

Taira

et al. 2010

The Journal of Dermatology

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Eyelid dermatitis and ⁄ or periocular dermatitis (ED ⁄ PD) is commonly seen in a variety of skin diseases such as seborrheic dermatitis, atopic dermatitis and psoriasis, but is most often associated with allergic contact dermatitis (ACD). Here, a case of ACD in an 82-year-old man is described; he used 0.1% diclofenac sodium eye drops and exhibited pruritic erythema on the eyelids. Patch test for diclofenac sodium eye drops was positive. Further patch tests revealed a positive reaction to diclofenac sodium (monosodium 2-[2, 6-dichlorophenylamino] phenylacetate), which was the main component in the eye drop medicine. Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID), and is frequently used in everyday oral medications, topical ointments, gel agents and eye drops. Case reports on ACD caused by diclofenac sodium eye drops are extremely rare. Nevertheless, it is necessary to consider ACD due to diclofenac sodium when a patient with ED ⁄ PD has a history of use of diclofenac sodium eye drops.

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Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis due to diclofenac sodium in eye drops

Miyazato

Yamaguchi

Taira

et al. 2010

The Journal of Dermatology

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“…More acute symptoms are associated with the treatment with gentamicin (27,30,(63)(64)(65)(66)(67)(68). It is possible that aminoglycoside-induced mitochondrial dysfunctions in humans may arise from off-target binding to human mitochondrial RNA, such as hmt69.…”

Section: Discussionmentioning

confidence: 99%

Evidence That Antibiotics Bind to Human Mitochondrial Ribosomal RNA Has Implications for Aminoglycoside Toxicity

Hong

Harris

Fanning

et al. 2015

Journal of Biological Chemistry

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“…Overall, allergic reactions to aminoglycosides reported in the literature are rare. Aminoglycosides come in multiple dosage forms, including topical, parenteral, and inhaled, and there have been reports of reactions from each dosage form, some being localized reactions, and others being systemic reactions [30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59]. Below and in Table 2, Table 3 and Table 4 is a summary of the reactions caused by gentamicin, tobramycin, and amikacin.…”

Section: Documented Allergic Reactionsmentioning

confidence: 99%

Aminoglycoside Allergic Reactions

et al. 2019

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Aminoglycosides are antimicrobial agents that are primarily used for infections caused by Gram-negative pathogens. The purpose of this article is to review the allergic reactions reported in the published literature to aminoglycoside antibiotics. A thorough PubMed search was conducted and excluded non-allergic adverse reactions to aminoglycosides. Allergic reactions to aminoglycosides occur infrequently, but can include cutaneous reactions as well as systemic reactions, including anaphylaxis. Of the evaluated aminoglycosides, gentamicin had the most reported allergic reactions, including the most reports of anaphylaxis, followed by tobramycin, and then amikacin. Most reports of allergic reactions occurred in patients who had a prior exposure to some dosage form of an aminoglycoside. Cross-reactivity among aminoglycosides is common and occurs due to the similarities in their chemical structures. Desensitization protocols to tobramycin have been described in the literature.

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Allergic contact dermatitis from gentamicin in eyedrops, with cross‐reactivity to kanamycin but not neomycin

Cited by 25 publications

References 1 publication

Allergic contact dermatitis due to diclofenac sodium in eye drops

Allergic contact dermatitis due to diclofenac sodium in eye drops

Evidence That Antibiotics Bind to Human Mitochondrial Ribosomal RNA Has Implications for Aminoglycoside Toxicity

Aminoglycoside Allergic Reactions

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