Allergic Contact Dermatitis from Etofenamate without Cross-Sensitization to Other Anthranilic Acid Derivatives

Allergic and photoallergic contact dermatitis from ketoprofen: results of (photo) patch testing and follow‐up of 42 patients*

“…PCA, PACA, or CA to etofenamate, an anthranilic acid derivative (AAD), being the active principle of Flexium gel, was observed in 24 of 36 patients tested. Until recently, (photo) contact sensitivity to etofenamate has been rarely reported (25) but this is perhaps underestimated. It is unclear why, in our test series, many patients suffer from simultaneous PCA from KP and etofenamate as they belong to different groups of NSAIDs (AADs versus APADs).…”

Allergic contact dermatitis to etofenamate. Cross‐reaction to other nonsteroidal anti‐inflammatory drugs

“…Allergic contact dermatitis because of etofenamate has rarely been reported (3–12). Patients who have etofenamate contact dermatitis showed (i) tolerance to other non‐structurally related NSAIDs (1, 2, 10) and (ii) lack of cross‐sensitivity with the most anthranilic derivatives, such as meclofenamate, niflumic, and mefenamic acid (2, 12).…”

“…Etofenamate is an anthranilic acid derivative used for its anti‐inflammatory properties in the treatment of musculoskeletal disorders, soft tissue trauma, and some inflammatory skin diseases. Allergic contact dermatitis to etofenamate has been rarely reported (1–12). However, topical preparations for rheumatism and sprains are widely used nowadays.…”

Atípusos haemorrhagiás bőrtünetek hátterében igazolt hajas sejtes leukaemia poliszenzibilizált betegen

“…Az NSAID-ok gyakori kontakt provokáló ágensek. Az etofenamát -2-(2-hidroxi-etoxi)etil-N-(α,α,α-trifluorm-tolil)antranilát -egy nemszelektív ciklooxigenáz (COX)-inhibitor, erősen lipofil antranilsav-származék, helyi gyulladásgátlóként az 1970-es évek óta alkalmazzák [4][5][6][7]. Analgetikus, antireumatikus, antipiretikus és antiinflammatorikus hatását a prosztaglandinszintézis gátlásán keresztül fejti ki, de NSAID-ként ismert a lokális vasospasmust és cirkulációt befolyásoló hatása is [4,[8][9][10][11][12].…”