Allergic contact dermatitis from Autan^® spray: methyl glucose dioleate as sensitizing ingredient

Allergic Contact Dermatitis due to an Insect Repellent: Double Sensitization to Picaridin and Methyl Glucose Dioleate

“…Methyl glucose dioleate, the di-ester of a methyl glucoside and oleic acid, is a water-in-oil emollient and emulsifier which is used in topical and cosmetic products because of its emollient, lubricant, moisturizing and viscous properties. Although the material safety data sheet for methyl glucose dioleate admits a possibility of mild irritancy, other cases of topical sensitization to methyl glucose dioleate have been described (11)(12)(13)(14)(15). Our observation seems to confirm the sensitizing potential of methyl glucose dioleate, supporting the opinion that contact allergies to this compound are not as rare as reported.…”

Allergic contact dermatitis caused by a nursing comfort balm: methyl glucose dioleate as the sensitizing ingredient

“…To our knowledge, this is the first case of allergic contact dermatitis caused by a breastfeeding nursing balm, in which the patient reacted to MGD. Although the material safety data sheet refers only to the possibility of mild irritancy but no sensitizing properties, allergic contact dermatitis caused by MGD has been reported (1–7). The allergen was contained in topical medicaments for leg ulcers (5, 6), an antifungal paste (4), insect repellents (1, 2), or cosmetic creams (3, 7).…”

Safety Assessment of Methyl Glucose Polyethers and Esters as Used in Cosmetics

“…A 27-year-old female presented with widespread eczema of the legs, arms, and face, approximately 8 hours after application of an insect repellant. 54 Methyl glucose dioleate is the main component of an ingredient of the repellant that is a water-in-oil emollient and emulsifier. Patch testing with the repellant yielded a positive reaction after 3 days (þD2/þþD3).…”