Allergic contact dermatitis from 2‐bromo‐2‐nitropropane‐1,3‐diol in Metrogel<sup>®</sup>

Choudry, K.; Beck, M. H.; Muston, Haydn L.

doi:10.1034/j.1600-0536.2002.460117.x

Cited by 15 publications

(4 citation statements)

References 6 publications

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“…Bronopol has since been replaced in Eucerin ® by methylchloroisothiazolin one/methylisothiazolinone (MCI/MI). Bronopol has also sensitized one patient who was using a metronidazole gel (Metrogel ® ) (43). Bronopol is no longer present in Metrogel, but is still found in other topical anti‐acne agents (FIG.…”

mentioning

confidence: 99%

Hypersensitivity to preservatives

Sasseville

2004

Dermatol Ther

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Preservatives are biocidal chemicals added to cosmetics, topical medicaments, consumer goods, foods, and industrial products to protect them against microbial spoilage and to protect the consumer against infection. The ideal preservative, both effective and devoid of irritant or sensitizing potential, is still to be discovered. The present paper reviews the most important classes of preservatives, namely parabens, formaldehyde-releasers, and isothiazolinones. The author also discusses newer agents such as Euxyl K 400 and isopropynyl butylcarbamate. Each preservative is described in terms of chemical and physical characteristics, antimicrobial efficacy, exposure, cutaneous adverse reactions, patch testing concentrations, patterns of cross-reactions, and reported rates of sensitization. The history of preservatives goes back to the 1930s, and ironically, the parabens, which the industry has sought to replace with "safer" alternatives, are still the most frequently used biocides in cosmetics and appear to be far less sensitizing than most of the newer agents.

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mentioning

confidence: 99%

Hypersensitivity to preservatives

Sasseville

2004

Dermatol Ther

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“…; Warshaw et al, n.d . ; Choudry et al, 2002 ; Podmore, 2000 ; Shaughnessy et al, 2014 ). In the Danish (Q)SAR Database, bronopol was positive for both respiratory sensitisation in humans and skin irritation in rabbits.…”

Section: Resultsmentioning

confidence: 99%

“…Bronopol has antimicrobial properties, and, to our knowledge, there are no available data on this substance on respiratory irritation or sensitisation, although dermal sensitisation has been described in several cases (e.g. Cheng et al, n.d.;Warshaw et al, n.d.;Choudry et al, 2002;Podmore, 2000;Shaughnessy et al, 2014). In the Danish (Q)SAR Database, bronopol was positive for both respiratory sensitisation in humans and skin irritation in rabbits.…”

Section: Bronopolmentioning

confidence: 99%

Asthma‐inducing potential of 28 substances in spray cleaning products—Assessed by quantitative structure activity relationship (QSAR) testing and literature review

Hadrup

Frederiksen

Wedebye

et al. 2021

J of Applied Toxicology

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Exposure to spray cleaning products constitutes a potential risk for asthma induction.We set out to review whether substances in such products are potential inducers of asthma. We identified 101 spray cleaning products for professional use.Twenty-eight of their chemical substances were selected. We based the selection on (a) positive prediction for respiratory sensitisation in humans based on quantitative

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“…Der Kontakt mit BNPD-konservierten Kosmetika oder Externa wird in einigen Berichten ebenfalls als mögliche Ursache einer Sensibilisierung gegen BNPD angesehen. (Choudry et al 2002). a.)…”

Section: Hautsensibilisierende Wirkungunclassified

2‐Brom‐2‐nitropropan‐1,3‐diol

2004

Gesundheitsschädliche Arbeitsstoffe

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Allergic contact dermatitis from 2‐bromo‐2‐nitropropane‐1,3‐diol in Metrogel^®

Cited by 15 publications

References 6 publications

Hypersensitivity to preservatives

Hypersensitivity to preservatives

Asthma‐inducing potential of 28 substances in spray cleaning products—Assessed by quantitative structure activity relationship (QSAR) testing and literature review

2‐Brom‐2‐nitropropan‐1,3‐diol

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Allergic contact dermatitis from 2‐bromo‐2‐nitropropane‐1,3‐diol in Metrogel®

Cited by 15 publications

References 6 publications

Hypersensitivity to preservatives

Hypersensitivity to preservatives

Asthma‐inducing potential of 28 substances in spray cleaning products—Assessed by quantitative structure activity relationship (QSAR) testing and literature review

2‐Brom‐2‐nitropropan‐1,3‐diol

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Allergic contact dermatitis from 2‐bromo‐2‐nitropropane‐1,3‐diol in Metrogel^®