Allergic contact dermatitis caused by Dermabond in a paediatric patient undergoing skin surgery

Li, Tianyu; Wan, Joy; McKenna, Rachel A.; Jackson, Oksana A.; Treat, James R.

doi:10.1111/cod.13125

Cited by 23 publications

(22 citation statements)

References 9 publications

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“…A new epidemic of ACD from glucose sensors has recently arisen, often also in children suffering from diabetes, a subject recently reviewed by Herman et al [82], and in which isobornyl acrylate was demonstrated to be the main sensitizing culprit [83], although also ethyl cyanoacrylate was reported as a cause as well [84,85], the latter cross-reacting to other cyanoacrylates increasingly used as a liquid skin adhesive Dermabond (Ethicon, Bridgewater, New Jersey) in plastic but also orthopedic surgery [86].…”

Section: Medical Devicesmentioning

confidence: 99%

Contact Allergy in Children

Goossens

Morren

2020

Contact Dermatitis

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Contact allergy in children is more frequent than previously suspected. Metals, ingredients of pharmaceutical and cosmetic products, preservatives/biocides, para-phenylenediamine, rubber additives, plastics and resins, and plants are known sensitizers in them. In adolescents, occupation-induced allergens may be involved as well. Sometimes unusual clinical presentations of allergic contact dermatitis can be observed. If there is a suspicion by history and clinical picture, or there is an unexplained eczema at particular body sites, patch testing should be performed at all ages. Patch testing in children is safe, but false-positive (as false-negative) reactions are, of course, possible. Patch test reactions must be interpreted carefully, particularly in atopic subjects, since their skin is readily irritated; this is especially the case for metals. An abbreviated baseline series, supplemented with relevant allergens from other test series, as well as contacted products and respective ingredients suggested by the history, should be patch tested.

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Section: Medical Devicesmentioning

confidence: 99%

Contact Allergy in Children

Goossens

Morren

2020

Contact Dermatitis

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“…Allergic contact dermatitis caused by cyanoacrylatebased medical adhesives has been frequently described in the literature, 2 with Dermabond being commonly implicated in numerous cases of tissue adhesive contact hypersensitivity. 3,4 Here, we describe a novel case of allergic contact dermatitis caused by VenaSeal following surgical intervention for venous incompetence.…”

mentioning

confidence: 99%

“…VenaSeal (Medtronic, Minneapolis, Minnesota) is a medical tissue adhesive containing n‐butyl‐2‐cyanoacrylate, and is injected endovenously for the treatment of varicose veins and venous incompetence. Allergic contact dermatitis caused by cyanoacrylate‐based medical adhesives has been frequently described in the literature, with Dermabond being commonly implicated in numerous cases of tissue adhesive contact hypersensitivity . Here, we describe a novel case of allergic contact dermatitis caused by VenaSeal following surgical intervention for venous incompetence.…”

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confidence: 99%

Allergic contact dermatitis caused by VenaSeal tissue adhesive

2019

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“…Patch testing was both positive to this tested "as is" and to diaminodiphenylmethane [247]. Cyanoacrylates are used as surgical glues, e.g., Dermabond™, and may cause ACD surrounding the site of an excision or wound repair [248]. In a review of 38 patients of a history of ACD to such surgical glues, mostly Dermabond™, found that just using ethyl cyanoacrylate 10% pet., which is available as commercial patch test allergen, only detected 29% of the cases and the addition of octyl cyanoacrylate 10% pet.…”

Section: Medical Devicesmentioning

confidence: 99%

Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

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Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were manually searched, covering the years 2018–2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N’-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just as we have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.

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Allergic contact dermatitis caused by Dermabond in a paediatric patient undergoing skin surgery

Cited by 23 publications

References 9 publications

Contact Allergy in Children

Contact Allergy in Children

Allergic contact dermatitis caused by VenaSeal tissue adhesive

Contact Allergy—Emerging Allergens and Public Health Impact

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