Allergic contact dermatitis caused by topical antiacne drugs

Veraldi, Stefano; Brena, Michela; Barbareschi, M.

doi:10.1586/17512433.2015.1046839

Cited by 17 publications

(15 citation statements)

References 48 publications

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“…It is commonly believed that contact dermatitis comprises 80% irritant contact dermatitis and 20% allergic contact dermatitis. Retinoid dermatitis had been thought to be allergic contact dermatitis, that is, a type IV delayed hypersensitivity reaction that occurs only in a sensitized individual . A strong relationship between ATRA and skin mast cells has been confirmed, as mast cell‐deficient Kit W‐sh/W‐sh mice did not show as serious dermatitis as WT mice .…”

Section: Discussionmentioning

confidence: 99%

All‐trans‐retinoic acid activated mast cells via Mas‐related G‐protein‐coupled receptor‐X2 in retinoid dermatitis

et al. 2019

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Background: Retinoic acid (RA)-induced dermatitis is the most frequent side-effect limiting its widespread use. However, the exact mechanisms triggering dermatitis are not fully understood, including the role of skin mast cells. The newly discovered Masrelated G-protein-coupled receptor-X2 (MRGPRX2) in mast cells mediates pseudoallergic drug reactions in several types of dermatitis. A possible contribution of MRGPRX2 to contact dermatitis induced by RA has hitherto not been examined. Objectives: To investigate whether all-trans-RA (ATRA) activates mast cells via MRGPRX2/MrgprB2 (the mouse orthologue), contributing to the pathogenesis of retinoid-induced dermatitis. Methods: Wild-type (WT) and MrgprB2 −/− mice were treated with topical ATRA to observe local inflammation and mast cell degranulation in vivo by the use of haematoxylin and eosin and immunofluorescence staining. Release of histamine and release of β-hexosaminidase were measured and calcium influx was detected in Laboratory of Allergic Disease 2 (LAD2) cells with specific knockdown targeting MRGPRX2 by small interfering RNA (siRNA) and in primary cells from MrgprB2 −/− mice. Results: As compared with WT mice, MrgprB2 −/− mice showed resistance to ATRAtriggered contact dermatitis and local inflammatory reactions in the paws. ATRA activated mast cells via the MrgprB2 pathway in murine cells, and via the MRGPRX2 pathway in human mast cells.Conclusions: ATRA-induced dermatitis could be achieved by activating mast cells via MRGPRX2/MrgprB2, which may provide a potential therapy target to reduce the side-effect. K E Y W O R D Sall-trans-retinoic acid (ATRA), contact dermatitis, mast cell, MRGPRX2

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Section: Discussionmentioning

confidence: 99%

All‐trans‐retinoic acid activated mast cells via Mas‐related G‐protein‐coupled receptor‐X2 in retinoid dermatitis

et al. 2019

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“…In some cases, ACD caused by clindamycin presented with atypical clinical pictures, such as rosacea‐like rash and erythema multiforme‐like eruption . Despite the fact that clindamycin is often used on large areas of the skin and for long periods of time, its potential for contact sensitization is apparently very low …”

Section: Discussionmentioning

confidence: 99%

“…Topical clindamycin is widely used for the treatment of acne. Cases of allergic contact dermatitis (ACD) caused by clindamycin are relatively rare . We describe a case of ACD caused by clindamycin in a woman with hidradenitis suppurativa/acne inversa (HS/AI).…”

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confidence: 99%

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Allergic contact dermatitis caused by clindamycin

et al. 2018

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“…It is also necessary to consider photosensitivity when using cosmetics, sunscreens, herbal extracts, etc. [25][26][27][28][29] . Th erefore, it is always necessary in practice to have in mind the possibility of reactions to topical drugs 30 .…”

Section: Drugs and Substances Associated With Sensitivity To The Sunmentioning

confidence: 99%

Drug-Induced Photosensitivity – a Continuing Diagnostic Challenge

Lugović-Mihić

Duvančić

Ferček

et al. 2017

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SUMMARY -When taking diff erent drugs, their possible side eff ects on the skin should be considered, including skin reactions connected to photosensitivity. Th is photosensitivity caused by drugs can appear as phototoxic reactions (which occur more often) or photoallergic reactions (which occur less often and include allergic mechanisms). Th e following drugs stand out as medications with a high photosensitivity potential: nonsteroidal anti-infl ammatory drugs (NSAIDs), cardiovascular drugs (such as amiodarone), phenothiazines (especially chlorpromazine), retinoids, antibiotics (sulfonamides, tetracyclines, especially demeclocycline and quinolones), etc. In recent years, photosensitive reactions to newer drugs have appeared, e.g., targeted anticancer therapies such as BRAF kinase inhibitors (vemurafenib, dabrafenib), EGFR inhibitors, VEGFR inhibitors, MEK inhibitors, Bcr-Abl tyrosine kinase inhibitors, etc. In patients taking drugs over a longer period of time (e.g., NSAIDs, cardiovascular drugs, etc.), a particular problem arises when an unrecognized drug-induced photosensitivity on the skin manifests in summer months. When taking patient histories, the physician/dermatovenereologist should bear in mind that any drug the patient is currently taking may be the cause of skin reactions. Th erefore, patients who use potentially photosensitive drugs and treatments on a long term basis should be warned of the possibility of these side eff ects on their skin and advised to avoid direct exposure to sunlight and to use adequate photoprotection. If patients carefully protect themselves from the sun, it is often not necessary to stop treatments that include photosensitive drugs. If such reactions appear, anti-infl ammatory and antiallergic therapies should be introduced.

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Allergic contact dermatitis caused by topical antiacne drugs

Cited by 17 publications

References 48 publications

All‐trans‐retinoic acid activated mast cells via Mas‐related G‐protein‐coupled receptor‐X2 in retinoid dermatitis

All‐trans‐retinoic acid activated mast cells via Mas‐related G‐protein‐coupled receptor‐X2 in retinoid dermatitis

Allergic contact dermatitis caused by clindamycin

Drug-Induced Photosensitivity – a Continuing Diagnostic Challenge

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