1975
DOI: 10.1001/archderm.1975.01630240037006
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Allergic Contact Dermatitis Caused by Idoxuridine

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Cited by 30 publications
(10 citation statements)
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“…Cirkel and van Ketel [78] described a patient sensitized to both idoxuridine and trifluoridine, pointing out the sensitizing properties of trifluormethylized trifluoridine and the likely cross-reactivity between this compound and idoxuridine. Interestingly, Amon et al [70] observed cross-reactivity among this agent and other brominated and chlorinated, but not fluorinated, pyrimidine analogues.…”
Section: Idoxuridine and Trifluoridinementioning
confidence: 98%
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“…Cirkel and van Ketel [78] described a patient sensitized to both idoxuridine and trifluoridine, pointing out the sensitizing properties of trifluormethylized trifluoridine and the likely cross-reactivity between this compound and idoxuridine. Interestingly, Amon et al [70] observed cross-reactivity among this agent and other brominated and chlorinated, but not fluorinated, pyrimidine analogues.…”
Section: Idoxuridine and Trifluoridinementioning
confidence: 98%
“…Idoxuridine allergic contact dermatitis has been described in at least 7 studies [70][71][72][73][74][75][76]. Relatively few cases showed positive reactions when patch tested with this drug; whereas many appeared to be due to the delivery vehicle components, including propylene glycol and dimethylsulfoxide [76].…”
Section: Idoxuridine and Trifluoridinementioning
confidence: 99%
“…Less than 20 cases have confirmed patch test positive to this drug; whereas the others appeared to be due to the delivery vehicle components including propylene glycol and dimethylsulfoxide (41). Interestingly, Amon et al (38) observed a pattern of cross‐reactivity of this agent with other brominated and chlorinated, but not fluorinated, pyrimidine analogues.…”
Section: Documented Casesmentioning
confidence: 99%
“…Idoxuridine has been demonstrated to be too toxic for parenteral use and is now only applied topically (16, 36–41). Less toxic and more effective agents have been developed for treatment of this condition and idoxuridine was probably the most well‐known cause of chronic follicular conjunctivitis among the antiviral agents (36, 39).…”
Section: Documented Casesmentioning
confidence: 99%
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