Allergic contact dermatitis caused by tocopheryl nicotinate

Abstract

González de Arriba M. Should methyldibromo glutaronitrile in the baseline series be tested? Results of the skin allergy unit of a fourth-level hospital in Spain.

Allergic contact dermatitis from vitamins: A systematic review

“…105 The vitamin E esterification seems to influence its immunogenic properties, since cross‐reactivity among different esters was not elicited by patch testing. 93 , 94 , 97 , 106 Given its increasing use in cosmetics and topical products, it has been suggested that vitamin E should be included in routine patch test series, 96 , 97 although the optimal concentration and vehicle are not known. Currently, there is no evidence that dietary vitamin E intake may induce a flare‐up of skin lesions in topically sensitized patients, although some authors recommend these patients to avoid vitamin E intake.…”

“…Furthermore, tocopheryl seems to be a stronger sensitizer than tocopherol, and probably acts as an adjuvant, since contact allergy to vitamin E is often associated to other sensitizations such as to vitamin A, 78,80 glycyrrhetinic acid, 100 decyl oleate, 98 and Aloe vera 105 . The vitamin E esterification seems to influence its immunogenic properties, since cross‐reactivity among different esters was not elicited by patch testing 93,94,97,106 . Given its increasing use in cosmetics and topical products, it has been suggested that vitamin E should be included in routine patch test series, 96,97 although the optimal concentration and vehicle are not known.…”

“…4,87 Besides their role as dietary supplements, vitamin E esters are largely used also as antioxidant and antiaging agents in cosmetics. 4 The first case of ACD to vitamin E was reported in 1965 by Brodkin et al 88 in a patient with an earlobe dermatitis after the local application of a cream containing vitamin E. 88 Since then, several cases of ACD to vitamin E have been described, contained in deodorants, 89,90 body oils, 91,92 hair lotions, 93 and moisturizers. 78,94 Vitamin E was the third most common contact allergen present in 151 of 276 samples of moisturizers (55%), after fragrances (68%) and parabens (62%).…”

“…96 ACD to vitamin E exhibits two main clinical patterns: an eczematous dermatitis involving the face and/or the extremities, and a generalized eruption spreading from the site of vitamin E application. 97 However, generalized skin eruptions may show different morphological patterns such as systemic allergy, 98,99 erythema multiforme-like, 92,93,100 and contact urticaria. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] Nevertheless, according to some authors, contact allergy to vitamin E is debatable.…”