Allergic contact dermatitis caused by dexpanthenol: report of two cases

Fernandes, Sónia; Macias, Vasco Coelho; Cravo, Mariana; Amaro, Cristina; Santos, Raquel; Cardoso, Jorge

doi:10.1111/j.1600-0536.2011.02005.x

Cited by 17 publications

(15 citation statements)

References 5 publications

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“…In 1995, Schmid‐Grendelmeier et al reported 7 cases of allergy to dexpanthenol, and reviewed the literature summarizing 40 published cases up to 1995. Since then, a few other cases have been reported, and, in 2017, Clerens and Goossens published a review of 23 patients with ACD caused by dexpanthenol among 3301 patients patch tested with dexpanthenol 5% pet. between 1990 and 2016, amounting to 0.7%, a frequency that is very similar to that in our study (0.89%).…”

Section: Discussionmentioning

confidence: 99%

“…Since then, a few other cases have been reported, 2,5,6,8,9 and, in 2017, Clerens and Goossens published a review of 23 patients with ACD caused by dexpanthenol among 3301 patients patch tested with dexpanthenol 5% pet. between 1990 and 2016, amounting to 0.7%, 1 a frequency that is very similar to that in our study (0.89%).…”

Section: Discussionmentioning

confidence: 99%

“…The allergic moiety of dexpanthenol involved in ACD remains uncertain. Inside the cell, dexpanthenol is rapidly converted to pantothenic acid and one of its components, β‐alanine, which could also possibly play a role in the induction of ACD . Lymphocyte transformation tests with dexpanthenol‐modified microsomes performed by Hahn et al suggested a specific T cell‐dependent reaction enhanced by microsomal‐dependent antigen metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Allergic contact dermatitis caused by dexpanthenol—Probably a frequent allergen

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Allergic contact dermatitis caused by dexpanthenol—Probably a frequent allergen

et al. 2018

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“…It is a frequent component of shampoos and hair conditioners as it coats and seals the hair surface, making hair appear more shiny 2,7 . Allergic contact dermatitis caused by panthenol is considered to be rare, but has been reported following the use of medicaments, moisturizers and sunscreens 1,2,4,5,7 . Allergic contact dermatitis caused by panthenol is considered to be rare, but has been reported following the use of medicaments, moisturizers and sunscreens 1,2,4,5,7 .…”

Section: Discussionmentioning

confidence: 99%

Pustular irritant contact dermatitis caused by dexpanthenol in a child

Güleç

Albayrak

Uslu

et al. 2014

Cutaneous and Ocular Toxicology

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Pustular irritant contact dermatitis is rare and unusual clinic form of contact dermatitis. Dexpanthenol is the stable alcoholic analogue of pantothenic acid. It is widely used in cosmetics and topical medical products for several purposes. We present the case of 8-year-old girl with pustules over erythematous and eczematous areas on the face and neck. To the best of our knowledge, this is the first case reported that is diagnosed as pustular irritant contact dermatitis caused by dexpanthenol.

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“…Dexpanthenol is an analogue of pantothenic acid (vitamin B 5 ) that is used in pharmaceuticals and cosmetics . Pantothenic acid is essential for the synthesis of coenzyme A in cells involving in the Krebs cycle.…”

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Allergic contact dermatitis caused dexpanthenol—But is that all?

et al. 2019

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Dexpanthenol is an analogue of pantothenic acid (vitamin B 5 ) that is used in pharmaceuticals and cosmetics. 1 Pantothenic acid is essential for the synthesis of coenzyme A in cells involving in the Krebs cycle. CASE REPORTA 49-year-old Caucasian man presented with generalized eczema of the trunk and limbs that had lasted for~10 days. Eight weeks before, he had sustained a few scratches on the right leg caused by plants during occupational gardening. He reported having applied a dexpanthenol-containing cream, and, a few days later, he developed local erythema and vesicles, with subsequent spreading.Allergic contact dermatitis caused by the topical drug was considered. Use of the cream was stopped, and the patient was treated with oral prednisolone. After rapid improvement, topical methylprednisolone aceponate cream was prescribed to achieve complete remission. However, the patient mentioned worsening of the residual dermatitis after applying the latter cream, and stopped using it. Physical examination showed an itchy erythematous desquamative plaque on the right leg (Supporting Information Figure S1).Patch testing with IQ Ultra chambers was performed with the Portuguese Contact Dermatitis Research Group baseline series, a cosmetics and excipients series (Chemotechnique Diagnostics, Vellinge, Sweden), and the dexpanthenol-containing cream used, tested "as is." Readings were performed on day 3 according to European Society of Contact Dermatitis guidelines, and showed positive reactions to cetearyl alcohol 20% pet., dexpanthenol 5% pet., and the dexpanthenol-containing cream. Both ingredients were present in the dexpanthenol-containing cream, and cetearyl alcohol was also present in the methylprednisolone aceponate cream (Figure 1).

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Allergic contact dermatitis caused by dexpanthenol: report of two cases

Cited by 17 publications

References 5 publications

Allergic contact dermatitis caused by dexpanthenol—Probably a frequent allergen

Allergic contact dermatitis caused by dexpanthenol—Probably a frequent allergen

Pustular irritant contact dermatitis caused by dexpanthenol in a child

Allergic contact dermatitis caused dexpanthenol—But is that all?

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