Allergic Contact Dermatitis Caused by Topical Eye Drops Containing Latanoprost

Lee, Ji Hye; Kim, Tae Hyung; Kim, Soo Chan

doi:10.5021/ad.2014.26.2.269

Cited by 7 publications

(8 citation statements)

References 10 publications

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“…ACD caused by latanoprost is apparently a very rare side‐effect . Indeed, there are only four published cases of hypersensitivity to latanoprost and one published case of hypersensitivity to bimatoprost, which is another prostaglandin F2α analogue . In the case reported here, skin tests and the clinical presentation were highly suggestive of ACD caused by latanoprost.…”

Section: Discussionmentioning

confidence: 59%

“…Since the introduction of latanoprost in 1996, some adverse reactions have been reported, the most frequent being conjunctival hyperaemia, hypertrichosis, and hyperpigmentation . ACD caused by latanoprost is apparently a very rare side‐effect . Indeed, there are only four published cases of hypersensitivity to latanoprost and one published case of hypersensitivity to bimatoprost, which is another prostaglandin F2α analogue .…”

Section: Discussionmentioning

confidence: 99%

“…2 Despite the extensive use of the drug in ophthalmology, allergic contact dermatitis (ACD) caused by latanoprost has rarely been reported in glaucoma patients. [3][4][5][6] We report a case of ACD very probably caused by latanoprost used for the treatment of alopecia areata in a woman.…”

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confidence: 99%

“…2 ACD caused by latanoprost is apparently a very rare side-effect. 3 Indeed, there are only four published cases of hypersensitivity to latanoprost 3-6 and one published case of hypersensitivity to bimatoprost, which is another prostaglandin F2α analogue. 7 In the case reported here, skin tests and the clinical presentation were highly suggestive of ACD caused by latanoprost.Moreover, to the best of our knowledge, all of the published cases concerned ophthalmic treatment, whereas the current case is the first to be reported after the use of latanoprost for alopecia.…”

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Allergic contact dermatitis probably caused by latanoprost during treatment for alopecia areata

et al. 2019

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Latanoprost is a phenyl-substituted analogue of prostaglandin F2α that is used to treat glaucoma. 1 Recently, it has been shown to stimulate eyelash hypertrichosis, and it has therefore been proposed as a possible treatment for alopecia. 2 Despite the extensive use of the drug in ophthalmology, allergic contact dermatitis (ACD) caused by latanoprost has rarely been reported in glaucoma patients. 3-6 We report a case of ACD very probably caused by latanoprost used for the treatment of alopecia areata in a woman. CASE REPORTA 58-year-old woman was referred to us with itchy eczema of her scalp, face, and neck. The dermatitis appeared after 2 months of topical treatment with 2 mL daily of a galenic preparation composed of minoxidil and latanoprost (minoxidil 5%, latanoprost 0.02%, propylene glycol 15%, and ethanol/water 70:30 79.98%) for diffuse multifocal alopecia areata. The patient reported that she had used minoxidil 2% solution for 5 months previously, without any skin reaction. The NAPOLITANO ET AL. 67 above topical treatment was stopped, and systemic and topical corticosteroid therapy was started. Almost complete clearance of the dermatitis was achieved after 7 days of treatment.After informed consent had been obtained, patch testing with the Società Italiana di Dermatologia Allergologica Professionale e Ambientale (SIDAPA) baseline series, propylene glycol 5% pet., eth. "as is"(FIRMA, Florence, Italy), the galenic preparation "as is" and freshly prepared minoxidil 5% eth. was performed with 8-mm chambers. Readings were performed on day (D) 2 and D4. A positive reaction (+) only to the galenic preparation was noted on D2. Later, other patch tests were performed with 0.005% latanoprost eyedrops (Xalatan; Pfizer, Madrid, Spain), with a positive (+) result (Figure 1), and with the preservative benzalkonium chloride 0.1% aq. (FIRMA) contained in Xalatan eyedrops, with a negative result. Moreover, a repeated open application test was performed with the galenic preparation applied twice daily on the patient's right antecubital fossa, and resulted in a pruritic, eczematous rash after 3 days (Figure 2). DISCUSSIONSince the introduction of latanoprost in 1996, some adverse reactions have been reported, the most frequent being conjunctival hyperaemia, hypertrichosis, and hyperpigmentation. 2 ACD caused by latanoprost is apparently a very rare side-effect. 3 Indeed, there are only four published cases of hypersensitivity to latanoprost 3-6 and one published case of hypersensitivity to bimatoprost, which is another prostaglandin F2α analogue. 7 In the case reported here, skin tests and the clinical presentation were highly suggestive of ACD caused by latanoprost.Moreover, to the best of our knowledge, all of the published cases concerned ophthalmic treatment, whereas the current case is the first to be reported after the use of latanoprost for alopecia. Given that the use of latanoprost for the treatment of alopecia is increasing, patients suspected of developing ACD should undergo patch testing to determine the causative...

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Allergic contact dermatitis probably caused by latanoprost during treatment for alopecia areata

et al. 2019

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“…Eyelid lesions must be differentiated from many conditions that can produce redness of the eyelids. Eczematous dermatological conditions such as contact dermatitis, atopic dermatitis, and seborrheic dermatitis commonly involve the eyelids 4 5 . Allergic contact dermatitis often affects the upper eyelids, while atopic dermatitis causes dermatitis in both the upper and lower eyelids.…”

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confidence: 99%

Mycosis Fungoides Diagnosed with an Initial Sign Resembling Benign Dermatosis on the Upper Eyelids

Lim

et al. 2015

Ann Dermatol

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Dermatitis alérgica de contacto a productos oftalmológicos: revisión de los alérgenos de uso frecuente en España

Pegalajar-García,

Coronel-González,

Navarro-Triviño

2024

Actas Dermo-Sifiliográficas

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Allergic Contact Dermatitis Caused by Topical Eye Drops Containing Latanoprost

Cited by 7 publications

References 10 publications

Allergic contact dermatitis probably caused by latanoprost during treatment for alopecia areata

Allergic contact dermatitis probably caused by latanoprost during treatment for alopecia areata

Mycosis Fungoides Diagnosed with an Initial Sign Resembling Benign Dermatosis on the Upper Eyelids

Dermatitis alérgica de contacto a productos oftalmológicos: revisión de los alérgenos de uso frecuente en España

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