Allergic contact dermatitis and photosensitivity to methylisothiazolinone and methylchloroisothiazolinone/methylisothiazolinone: Portrait of an epidemic in Brazil

Villarinho, Ana Luiza Castro Fernandes; Melo, Maria das Graças Mota; Teixeira, Liliane Reis

doi:10.1111/cod.13456

Cited by 4 publications

(1 citation statement)

References 8 publications

(19 reference statements)

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“…In Brazil, in a specific study to detect allergies with the main isothiazolinones, MI was positive in 26.7% of patients, with a clinical relevance of 93.8%. Those authors found that 35.7% of the participants who tested positive for MI had negative results for MCI/MI at 0.02% (31).…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 98%

Prospective study of consecutive patch testing in patients with contact dermatitis using an adapted Latin American baseline series

Belluco

Giavina‐Bianchi

Belluco

et al. 2023

Eur Ann Allergy Clin Immunol

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Background: Contact dermatitis is a disease characterized by pruritic skin lesions with high prevalence rates. The patch test is an instrument to evaluate contact allergies. Current data on characteristics of the affected population and studies about patch testing using adequate baseline series are needed. Objectives:To describe the clinical and epidemiological characteristics of a population with suspected contact dermatitis who underwent to a patch testing using an adapted Latin American baseline series in the departments of allergy and dermatology of a referral center in Brasília, Brazil, between March and December 2020.Methods: Observational, descriptive and analytical clinical study with prospective data collection was performed in consecutively evaluated patients at a referral center. The results of 208 participants who underwent patch testing using an adapted Latin American baseline series containing 40 allergens were analyzed, and the prevalence of contact allergies was compared with data from the literature. Pearson's chi-square test was used to calculate the odds ratio and respective 95% confidence interval for qualitative variables. Quantitative variables were compared using the Mann-Whitney U test. The four most prevalent allergens were entered into multiple binary logistic regression models as response variables to identify the main explanatory variables associated with these allergies. The significance of the regression parameters was tested using the Wald statistical test. Results:The mean age of participants was 42.6 years. A total of 69.7% had one or more positive tests. Among those with positive tests, 82.8% were women (OR = 1.371; p = 0.398). The hands were the most commonly affected site at 43%. An occupational history was detected in 19.2%. The most common allergen was nickel sulfate (32.2%), followed by sodium tetrachloropalladate (19.7%), fragrance mix I (15.4%), and methylisothiazolinone (13.5%). In multivariate logistic regression models, nickel was significantly related to female sex (p < 0.05), as well as palladium (p < 0.05). Fragrance mix I was related to a family history of allergy (p < 0.05). On the other hand, methylisothiazolinone was statistically significantly related to face (p < 0.05) and hand (p < 0.001) lesions. Conclusion:This study demonstrated a detailed profile of a population with suspected allergic contact dermatitis. Our patch test results, using an adapted Latin American baseline series, represent a significant update of this important diagnostic tool.

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Section: F O R P U B L I C a T I O Nmentioning

confidence: 98%

Prospective study of consecutive patch testing in patients with contact dermatitis using an adapted Latin American baseline series

Belluco

Giavina‐Bianchi

Belluco

et al. 2023

Eur Ann Allergy Clin Immunol

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Cutaneous Photosensitivity Diseases

Ibbotson

2024

Rook's Textbook of Dermatology

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The photodermatoses are a diverse group of conditions in which abnormal responses to light exposure are the hallmark. Photodiagnostic investigations through a specialist unit may be essential to ensure accurate diagnosis and management, and this chapter explores the nature of the photodermatoses and the photodiagnostic techniques that can be applied. Management approaches include early diagnosis, prevention and disease suppression, and awareness of the significant adverse impact on well‐being and psychological health that can occur with photosensitivity. Photoprotection is a mainstay approach for the photodermatoses but is often not sufficient alone for disease control. Desensitisation through natural hardening or light‐based therapies may be feasible, although systemic immunosuppressants and immunomodulators may be required. Awareness of the possibility of vitamin D deficiency is also necessary. This chapter will cover these approaches in detail.

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Decision making in next generation risk assessment for skin allergy: Using historical clinical experience to benchmark risk

Reynolds¹,

Gilmour²,

Baltazar³

et al. 2022

Regulatory Toxicology and Pharmacology

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Allergic contact dermatitis and photosensitivity to methylisothiazolinone and methylchloroisothiazolinone/methylisothiazolinone: Portrait of an epidemic in Brazil

Cited by 4 publications

References 8 publications

Prospective study of consecutive patch testing in patients with contact dermatitis using an adapted Latin American baseline series

Prospective study of consecutive patch testing in patients with contact dermatitis using an adapted Latin American baseline series

Cutaneous Photosensitivity Diseases

Decision making in next generation risk assessment for skin allergy: Using historical clinical experience to benchmark risk

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