Allergic contact dermatitis and conjunctivitis to corticosteroids

Abstract

This is a report of two patients suspected of having allergic dermato-conjunctivitis due to corticosteroids. Both were tested with the constituents of the ointments they were using, that is, corticosteroids, antibacterial agents, preservatives, and other active ingredients of the ointment bases. Both patients showed positive allergic patch test reactions to the respective corticosteroid betamethasone valerate, and one to hydrocortisone, neomycin, and a rubber additive. The importance of routine patch testing in ophthalmic practice to detect sensitizers in cases of allergy is mentioned. Hydrocortisone (25%) in petrolatum is recommended for patch testing.

Allergic Contact Dermatitis Following Ocular Use of Corticosteroids

“…13 Despite the wide ocular use of CSs, only few cases of patients experiencing allergic reactions have been reported. 4,[7][8][9][10][11][14][15][16][17] For example, Alani in 1976 14 was the first to report 2 patients suspected of allergic dermato-conjunctivitis due to CSs: they were both tested with the constituents of the ointments applied and showed positive patch test reactions to betamethasone valerate and to hydrocortisone, respectively. Mathias et al 15,16 described 3 patients, suffering from chronic iridocyclitis, who developed severe conjunctival inflammation following retrobulbar injections with a methylprednisolone-acetate suspension.…”

Towards the Ontology Organization for Semantic Searching

“…In this section some general guidelines are proposed for the construct of an ontology to facilitate information sharing via a Web search engine. [1] .…”

Delayed systemic allergic reactions to corticosteroids

“…3 Biopsy of the positive intradermal test site showed a perivascular:tperiappendageal mononuclear dermal infiltrate. 4 Subject (b) was also patch tested with methylprednisolone succinate, which was negative. 5 Additional testing included systemic provocation; in patient (a) oral…”