Allergic Complications of Hyaluronidase Injection: Risk Factors, Treatment Strategies, and Recommendations for Management

Guliyeva, Günel; Huayllani, María T.; Kraft, Casey T.; Lehrman, Craig; Kraft, Monica

doi:10.1007/s00266-023-03348-5

Cited by 6 publications

(2 citation statements)

References 60 publications

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“…Occasionally, an allergy to hyaluronidase has been observed. One risk factor is a previous sensitization to bee or wasp venom [92].…”

Section: Discussionmentioning

confidence: 99%

Filler Migration after Facial Injection—A Narrative Review

Wollina,

Goldman

2023

Cosmetics

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Background: The injection of dermal fillers for facial esthetics has become a very popular procedure. Although usually safe in the hands of the experienced user, filler injections may bear a risk of unwanted side effects. Material and Methods: This is a narrative review of dermal filler migration after facial injections. We performed research on the literature on Pubmed and Google Scholar. Inclusion criteria were observational studies, case reports, and clinical trials which investigated the association of facial filler injections to filler migration. Animal studies have not been considered. Intravascular injections were excluded. Results: We identified 28 reports that met the inclusion criteria. The age range of affected patients was 21 to 86 years (mean ± standard deviation: 47 ± 14.8 years). Women were 25 times more reported than males. Hyaluronic acid and polyalkylimide were the most commonly encountered filler substances. Injections into the nose, lips, nasolabial folds, and forehead (including glabella) are more often reported for filler migration than injections into the cheeks. Tear-trough correction bears a risk for orbital migration. The delay from injection to presentation of filler migration was highly variable. Very late filler migration was more commonly seen with permanent fillers than non-permanent products. Conclusions: Filler migration distant from the injection site can occur even several years after the primary treatment. All filler types can be involved. Permanent fillers bear a higher risk of very late filler migration. Migration of permanent fillers needs surgical treatment, while HA fillers respond to hyaluronidase injections. Detailed knowledge of facial anatomy, safer injection techniques, and filler qualities are preventive measures.

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“…Occasionally, an allergy to hyaluronidase has been observed. One risk factor is a previous sensitization to bee or wasp venom [92].…”

Section: Discussionmentioning

confidence: 99%

Filler Migration after Facial Injection—A Narrative Review

Wollina,

Goldman

2023

Cosmetics

View full text Add to dashboard Cite

show abstract

“…As most allergic responses to hyaluronidase present as immediate hypersensitivity reactions, it is advisable to administer the smallest possible amount. 9 , 10 here is a threshold for allergic reactions, representing the minimum amount required to trigger such a response. Consequently, administering a minimal injection may prevent allergic reactions from occurring.…”

mentioning

confidence: 99%