Allergic Acute Coronary Syndrome—Kounis Syndrome

Alblaihed, Leen; Veld, Maite A. Huis in ‘t

doi:10.1016/j.iac.2022.10.010

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…Mast cells are predominantly found in the cardiovascular system at coronary plaque sites and may infiltrate areas of plaque erosion or rupture. The number of cardiac mast cells is up to 200 times higher in patients with coronary plaques compared to the coronary arteries of healthy individuals ( 9 ). Therefore, it can be hypothesized that patients with severe coronary atherosclerotic plaques are at higher risk of developing KS syndrome, even if there is no previous history of allergy.…”

Section: Discussionmentioning

confidence: 99%

“…Mast cell activation in Acute Coronary Syndromes (ACS) is considered a primary event,not a result of coronary artery spasm. There is evidence that tryptase levels are elevated in peripheral blood during spontaneous myocardial ischemia, whereas they are not elevated during drug-induced coronary artery spasm, this situation also proves it (9). Literature suggests that while any drug can potentially induce KS, common culprits include antibiotics, analgesics, anesthetics, anti-tumor drugs, herbal medicines, and contrast media (10).…”

Section: Etiology and Pathophysiological Mechanismsmentioning

confidence: 99%

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Case Report: A case of Kounis syndrome induced by iodine contrast agent during coronary angiography

Sun,

Zhang

2024

Front. Cardiovasc. Med.

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Kounis Syndrome (KS), a seldom-seen adverse reaction to iodine contrast agents, has an incidence that remains unclear. At present, there are no unified guidelines for managing KS either nationally or internationally. Ioversol, a new triiodinated hypotonic nonionic contrast agent, is commonly used in cardiovascular Computed Tomography (CT) and vascular imaging for diagnostic purposes. Its principal adverse reactions encompass fever, dermatological responses, convulsions, respiratory distress, hypersensitivity reactions including KS, and acute renal injury. This paper documents a case of KS induced by an iodine contrast agent during coronary angiography and, at the same time, searches for related literature and carries out a summary analysis in an attempt to provide a dependable reference for clinicians to make accurate diagnoses and treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Etiology and Pathophysiological Mechanismsmentioning

confidence: 99%

Case Report: A case of Kounis syndrome induced by iodine contrast agent during coronary angiography

Sun,

Zhang

2024

Front. Cardiovasc. Med.

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“…In addition, ECG findings such as arrhythmias, elevated or depressed ST segments, any degree of cardiac block, 25 and a variety of electrocardiographic changes may be associated with the cardiac symptoms of Kounis syndrome. 30 In terms of laboratory findings, in addition to cardiac troponin, increases in serum tryptase, histamine, and cardiac biomarkers are particularly useful findings. 24 , 27 …”

Section: Discussionmentioning

confidence: 99%