Allergenicity and Linear Epitope Analysis of Scy p 8, an Allergen from Mud Crab
Fei Xia,
Mengsi Li,
Qingmei Liu
et al.
Abstract:Scy p 8 (triosephosphate isomerase) as a crab allergen
in inducing
distinct T-helper (Th) cell differentiation and a linear epitope associated
with allergenicity remain elusive. In this study, mice sensitized
with Scy p 8 exhibited significantly upregulated levels of IgE, IgG1,
and IL-4 release, inducing a Th2 immune response. Moreover, the release
of IFN-γ (Th1) and the levels of Treg cells were downregulated,
while IL-17A (Th17) was upregulated, indicating that Scy p 8 disrupted
the Th1/Th2 balance and Th17/… Show more
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