Allergenicity and antigenicity of fenugreek (Trigonella foenum-graecum) proteins in foods

Fæste, Christiane Kruse; Namork, Ellen; Lindvik, Helene

doi:10.1016/j.jaci.2008.09.012

Cited by 56 publications

(63 citation statements)

References 20 publications

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“…As regards the toxicity of fenugreek treatment is concerned, in some patients rhinorrhea, wheezing, facial angioedema, and fainting was reported (Patil et al, 1997;Faeste et al, 2009). It was interesting to notice that in certain ethnic groups, use of fenugreek seeds as food and herbal remedy, caused myopathy that was confirmed in ruminants (Egyed and Shlosberg, 1983).…”

Section: Introductionmentioning

confidence: 99%

Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes

Al-Ashban¹,

Abou‐Shaaban²,

Shah³

2010

Oriental Pharmacy and Experimental Medicine

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SUMMARYAcute (24 h) and chronic (90 days) oral toxicity studies on the ethanol extract of Trigonella foenumgraecum Leguminosae (L.) seeds were carried out. Acute dosages were 0.5, 1.0 and 3 g/kg while chronic dosage was 100 mg/kg per day of the extract. All morphological, biochemical, haematological and spermatogenic changes, in addition to mortality, body weight changes and any change in vital organs were recorded. Histopathological investigations were done on vital organs. Growth arrest in the treated animals was observed. The treated mice gained no significant weight during chronic treatment while there was a significant gain in body weight of the control group mice. Biochemical studies revealed a significant decrease in blood sugar levels of fenugreek treatment groups while haematological parameters remained comparable to the control. In the treatment, male group there was a significant decrease in weight of testes as compared to the control. There was a marginal weight gain in kidney weight of mice after chronic treatment as compared to the control. Fenugreek chronic treatment caused a highly significant spermatotoxic effects in male mice.

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Section: Introductionmentioning

confidence: 99%

Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes

Al-Ashban¹,

Abou‐Shaaban²,

Shah³

2010

Oriental Pharmacy and Experimental Medicine

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“…This plant seeds were reported to contain 35% alkaloids, 10% flavonoids (100 mg per g of fenugreek seeds), 4.8% saponins and 0.2-0.9% diosgenin (Jani, 2009;Meghwal, 2012;Vaidya, 2013). Alkaloids, along with some other volatile compounds, are mainly responsible for the bitter taste and typical aroma of fenugreek (Kumar, 2012, Faeste, 2009. Additionally, it is a significant source of vitamin B1, iron, silicon, sodium, protein, amino acids, fatty acids and dietary fiber (Sharma et al, 1990).…”

Section: Fenugreek Phytochemicals and Nutrientsmentioning

confidence: 99%

“…In male rabbits: decrease of testis weight, plasma concentration of androgens and sperm production Bin-Hafeez et al (2003) Leaves and seeds Reduction of perspiration, fever, allergies, bronchitis and congestion Faeste et al (2009) Seeds Treatment of sinus and lung congestion Singhal et al (1982) 26 Leaves and seeds Antimicrobial Sowmya and Rajyalakhsmi (1999) Leaves and seeds Treatment of hypertension and hypercholesterolemia Sowmya and Rajyalakhsmi (1999); Roberts (2012) Leaves and seeds Prevention of gas formation in digestive tract Mathern (2009) Steroids, flavonoids, alkaloids Raw material for hormones and pharmaceuticals Blank (1996) Leaves and seeds Antibacterial, anticancer, antiulcer, antinociceptive Sowmya (1999);Mathern (2009) Antifungal activity on Candida albicans, C. glabrata and C. tropicalis Sautor (2004) Inhibition of replication of hepatitis C virus (HCV) Wang (2011) Decrease of glycaemia and intestinal disaccharidases in vivo…”

Section: Diosgeninmentioning

confidence: 99%

Review on Fenugreek (Trigonella foenum-graecum L.) and its Important Secondary Metabolite Diosgenin

Chaudhary¹,

Chaudhary²,

Chikara³

et al. 2018

Not Bot Horti Agrobo

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Fenugreek (Trigonella foenum-graecum L.) is a medicinal plant used worldwide since ancient times. Its use as smelling agent and spice was documented since 15 th century. The genus Trigonella includes around 260 species diffused worldwide and belonging to Fabaceae family. In the last decades, a number of studies highlighted the biological activities and therapeutic properties of this species mainly attributed to bioactive secondary metabolites such as alkaloids, flavonoids, steroids and saponins. In particular, diosgenin, a steroidal saponin, has been investigated for its medicinal uses and fenugreek has been reported as source of raw material for the production of steroidal hormones. This review article focuses on the cultivation, genetics, ecophysiology and traditional uses of fenugreek, as well as on its medicinal properties, phytochemical and nutrient contents. Extraction procedures and pharmacological activities of diosgenin are also reviewed, as well as methods for its chemical analyses. This review focuses on the medicinal importance of Fenugreek and its important secondary metabolite diosgenin. The review article complies the results of pre-clinical studies conducted to establish the various medicinal applications of diosgenin. This will help researcher to discover fundamental role of diosgenin as a potential product for drug manufacturers and use of fenugreek as a source of diosgenin.

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“…Alkaloid, flavonoids and saponin: Fenugreek contains different alkaloids, flavonoids and saponins (23,24) that the latter one is in the highest concentration (25). Alkaloid and volatile constituents of fenugreek seeds are the two major components which cause bitter taste and bad odor (26). The level of flavonoid in fenugreek is more than 100 mg per g of seed (5).…”

Section: Vitamins and Mineralsmentioning

confidence: 99%

Fenugreek: Potential Applications as a Functional Food and Nutraceutical

Khorshidian¹,

Asli²,

Arab³

et al. 2016

Nutr Food Sci Res

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A B S T R A C TFenugreek (Trigonella foenum graecum), native to southern Europe and Asia, is an annual herb with white flowers and hard, yellowish brown and angular seeds, known from ancient times, for nutritional value beside of it medicinal effects. Fenugreek seeds are rich source of gum, fiber, alkaloid, flavonoids, saponin and volatile content. Due to it's high content of fiber, fenugreek could be used as food stabilizer, adhesive and emulsifying agent to change food texture for some special purposes. Some evidences suggest that fenugreek may also be regarded as antidiabetic, anticarcinogenic, remedy for hypocholesterolemia and hypoglycemia, antioxidant, antibacterial agent, gastric stimulant, and anti-anorexia agent. The present article is aimed to review the potential applications of fenugreek as a functional food and nutraceutical.

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Allergenicity and antigenicity of fenugreek (Trigonella foenum-graecum) proteins in foods

Cited by 56 publications

References 20 publications

Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes

Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes

Review on Fenugreek (Trigonella foenum-graecum L.) and its Important Secondary Metabolite Diosgenin

Fenugreek: Potential Applications as a Functional Food and Nutraceutical

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