Allergen‑removed Rhus�verniciflua Stokes suppresses invasion and migration of pancreatic cancer cells through downregulation of the JAK/STAT and Src/FAK signaling pathways

Abstract

Pancreatic cancer is a leading cause of mortality and morbidity worldwide. Due to drug resistance, and the high toxicity and adverse side effects of existing chemotherapeutic drugs, the current treatment of highly aggressive pancreatic cancer is considered inadequate. Allergen‑removed Rhus verniciflua Stokes (aRVS) has a strong antiproliferative effect in various cancer cells, and due to its low toxicity, it has emerged as an attractive candidate for cancer treatment. However, the potential use of aRVS as a treatment for pancreatic cancer is relatively unexplored. The present study examined the effects of aRVS on the invasion and migration of pancreatic cancer cells, and identified the molecular mechanisms underlying its anticancer effects. aRVS inhibited the Janus kinase/signal transducer and activator of transcription pathway in pancreatic cancer cells, and decreased the protein expression of mucin 4. In addition, it inhibited the activation of focal adhesion kinase and Src signaling, and decreased the expression of matrix metalloproteinase 9, which may reduce the migration and invasion of pancreatic cancer cells. In conclusion, the present study suggested that aRVS may be a potential treatment for aggressive pancreatic cancer.

Identify potential clinical significance of long noncoding RNA forkhead box P4 antisense RNA 1 in patients with early stage pancreatic ductal adenocarcinoma

“…Therefore, prevention of angiogenesis is a valuable treatment for cancer, such as pancreatic cancer . Numerous studies have shown that specific molecules can affect the tumorigenesis, progression, incursion as well as migration of pancreatic cancer by participating in the regulation of JAK/STAT pathway . MAPKKK cascade is the key molecule in the MAPK pathway, and MAPK pathway can be incorporated to control cell propagation, invasion, migration, apoptosis, tumorigenesis, and progression of pancreatic tumor, as well as chemotherapy response and clinical outcomes .…”

“…[38][39][40] Numerous studies have shown that specific molecules can affect the tumorigenesis, progression, incursion as well as migration of pancreatic cancer by participating in the regulation of JAK/ STAT pathway. [41][42][43][44] MAPKKK cascade is the key molecule in the MAPK pathway, and MAPK pathway can be incorporated to control cell propagation, invasion, migration, apoptosis, tumorigenesis, and progression of pancreatic tumor, as well as chemotherapy response and clinical outcomes. [45][46][47][48][49][50][51] For the two drugs that were identified in our current study, no previous studies have identified their functions on cancer treatment.…”

Immune Checkpoint PD-1/PD-L1 CTLA-4/CD80 are Blocked by Rhus verniciflua Stokes and its Active Compounds

“…Many preclinical studies have been carried out on the anticancer effects of RVS [15,16,17,18,19,20,21], including, in two cases, clinical reports of treatment for metastatic renal cell carcinoma [22]. To our knowledge, there has been no report of an immuno-oncological study on RVS.…”

Genotoxicity of Water Extract from Bark-Removed Rhus verniciflua Stokes

“…Several fractions and allergen-removed extracts from RVS have proven pharmacological effects, such as antioxidant [16,17], antimicrobial [18,19] or antiinflammatory effects [20,21]. In addition, anticancer activities of RVS in allergen-removed extracts have been reported in both experimental [22][23][24] and clinical studies [25]. We also reported the antiemetic and myelo-protective effects of allergen-removed RVS extracts using a cisplatin-injected animal model [26].…”