Allergen immunotherapy practice in the United States: guidelines, measures, and outcomes

Cox, Linda; Esch, Robert E.; Corbett, Mark; Hankin, Cheryl S.; Nelson, Michael R.; Plunkett, Greg

doi:10.1016/j.anai.2011.06.018

Cited by 55 publications

(36 citation statements)

References 29 publications

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“…Purified allergens are helpful for CRD and immunotherapy of HDM allergy (25). Treatments for HDM allergy include HDM avoidance and AIT, which is a widely recommended strategy and well documented (26). AIT is effective when appropriate doses of allergens are administrated (27).…”

Section: Discussionmentioning

confidence: 99%

Generation and purification of monoclonal antibodies against Der f 2, a major allergen from <i>Dermatophagoides farinae </i>

Chen

Zhang

Wang

et al. 2016

DD&T

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Section: Discussionmentioning

confidence: 99%

Generation and purification of monoclonal antibodies against Der f 2, a major allergen from <i>Dermatophagoides farinae </i>

Chen

Zhang

Wang

et al. 2016

DD&T

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“…Treatment of common infectious diseases (such as influenza, rabies and tuberculosis) and many allergies often requires a regular dosage of vaccines 13,14 and allergens 15 in specific quantities at periodic times to have desired biological response.…”

Section: Importance Of Pulsatile Releasementioning

confidence: 99%

Barrier-Mediated Pulsatile Release

Gandhi

Gosse

Nishii

et al. 2015

Journal of Membrane Science

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ii To my loving wife and wonderful parents.iii ACKNOWLEDGMENTS First and foremost I would like to thank my research advisor Dr. Eric Nuxoll for his support, brilliant advice, professionalism and endless patience. He has been a great mentor throughout my doctoral studies at the University of Iowa since I became his first graduate student. Besides overall research skills, I learned much more including how to address a problem in a practical way, determine priorities and most importantly how to express and defend ideas. I have had the privilege to work with very talented undergrad students Matthew Gosse and Derek Baerenwald, who directly contributed to this project. I am also grateful to Yasuhiro Nishii, a visiting scholar from Japan, for his partial contributions to this work and continued work forward with this project. Guiding and mentoring these bright individuals was an exciting opportunity and also a great experience for me. Others who have helped me along the way include my fellow research group members Ann O'Toole, Joel Coffel, Erica Bader and Bryce Hundley. iv I am incredibly grateful to my parents who have always supported me. I have been blessed to be born in a loving family that has fully encouraged and enabled me to achieve my dreams. Finally, no words can express my thankfulness to Khushbu, my wife, who always stood by me throughout this journey. Without her encouragement and motivation I would not have pursued the education to the length I have.v ABSTRACT Solutes are often most efficiently deployed in discrete pulses, for example in the delivery of herbicides or drugs. Manual application of each pulse can be labor-intensive, automated application of each pulse can be capital intensive, and both are often costly and impractical. Barrier-Mediated Pulsatile Release (BMPR) systems offer a materialsbased alternative for automated pulsatile drug delivery, without pumps, power supplies, or complex circuitry. While earlier materials-based approaches such as delayed-release microcapsules are limited to two or three pulses due to the independent nature of each pulse's timing control, BMPR systems link the timing of each pulse to the previous pulse.Each dose of drug is sequestered in its own stimuli-sensitive depot, releasing only upon contact with the stimulant. These depots are stacked with sacrificial barriers in between, each of which block the stimulant for a predetermined time. For instance, layers of soluble drug may be separated by degradable polymer layers. Water, as the stimulant, will erode the polymer layer over a fixed period of time, followed by quick dissolution and release of the underlying drug and the start of degradation for the next polymer layer.This example, however, is quickly limited by irregular polymer erosion, a single stimulant (water), and difficulty in scaling delay times.The research work presented in this thesis reports the development of a generalized BMPR system which overcomes those limitations. Model drugs (methylene blue and methyl orange) were immobilized in a pH-sensitive ...

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“…Studies have reported differences in the antigenicities of the pollens of various allergenic plants. Therefore, detailed information regarding the antigenicity of each species is needed (Calenoff et al 1990;Park et al 1999;Shahali et al 2007;Cox et al 2009Cox et al , 2011. The purpose of this study was to investigate the antigenicity of pine pollen, especially P. densiflora, P. thunbergii, and P. rigida pollen, derived from Korean pine plants.…”

Section: Introductionmentioning

confidence: 99%

Comparison of IgE induction in mice by pollens from three pine tree species

Kim

Choi

2017

j ecology environ

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Background: Over the years, pine pollens have been excluded as an allergen due to its relatively large size, low protein content, and waxy hydrophobic layer, despite their abundance. However, recent studies suggest the possibilities of pine pollens being allergens, and it has been reported that allergy symptoms were highly prevalent in areas with considerably large pine forests and high possibility of exposure to the pollen. Therefore, we conducted a comparative analysis of the allergenicities of the pollens from the dominant species of Korean pines, red pine (Pinus densiflora), black pine (Pinus thunbergii), and pitch pine (Pinus rigida), in mice. Methods: The protein composition of the pollens from the three pine species was compared via sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The pine pollens and proteins extracted from the pollens were introduced to BALB/c mice by nasal inhalation and application to exposed skin and the IgE produced by the mice were extracted from blood and analyzed via ELISA. Results: SDS-PAGE showed differing protein compositions of the pollens of the three pine species. Analysis of blood IgE compositions showed a similar amount of IgE produced when pollens were applied to skin. In contrast, when mice inhaled the pollens, P. densiflora was shown to induce significantly more IgE production than those of the other two species. Conclusions: The experimental results demonstrate that the pollens of all three South Korean pine species induce IgE production, and this production was more pronounced when the pollens were inhaled than when they were applied to the skin. Of the three species, the pollen of P. densiflora was found to induce the highest level of IgE production.

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Allergen immunotherapy practice in the United States: guidelines, measures, and outcomes

Cited by 55 publications

References 29 publications

Generation and purification of monoclonal antibodies against Der f 2, a major allergen from <i>Dermatophagoides farinae </i>

Generation and purification of monoclonal antibodies against Der f 2, a major allergen from <i>Dermatophagoides farinae </i>

Barrier-Mediated Pulsatile Release

Comparison of IgE induction in mice by pollens from three pine tree species

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