Allergen Immunotherapy in children with respiratory allergic diseases

Arasi, Stefania; Pajno, Giovanni Battista; Panasiti, Ilenia; Sandoval, Mónica; Alvaro‐Lozano, Montserrat

doi:10.23736/s0026-4946.20.05959-9

Cited by 8 publications

(9 citation statements)

References 91 publications

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“…In developing countries, bronchial pneumonia is one of the most common diseases for young children with high rates of hospitalization and mortality 16 . Take China as an example, bronchial pneumonia in children occurs 0.06–0.27 per child a year, and about 1840 to 12 230 per million children fail to recover 17–19 . Thus, developing early diagnosis and effective intervention are of great importance.…”

Section: Discussionmentioning

confidence: 99%

“…16 Take China as an example, bronchial pneumonia in children occurs 0.06-0.27 per child a year, and about 1840 to 12 230 per million children fail to recover. [17][18][19] Thus, developing early diagnosis and effective intervention are of great importance. Bronchial pneumonia in children is caused by microbe infections, and the pathogens include bacteria, virus, fungus, protozoa, and some noxious chemicals.…”

Section: Discussionmentioning

confidence: 99%

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The therapeutic effects of naringenin on bronchial pneumonia in children

Yao

Zhang

et al. 2021

Pharmacology Res & Perspec

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Bronchial pneumonia, also known as lobular pneumonia, is a common infectious disease in children, especially in toddlers and infants. 1 Bronchial pneumonia in children often occurs in winter and spring, when the weather is cold and unpredictable. Bronchial pneumonia in children is usually induced by pathogenic infection, such as bacteria, viruses, molds, mycoplasma pneumoniae, as well as superinfection of viruses and bacteria. 2,3 The primary clinical symptoms include high grade fever, cough, breathlessness, and permanent pulmonary medium or fine moist rales, even respiratory failure in some severe cases. [4][5][6] Current available therapeutic drugs for the treatment of bronchial pneumonia

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The therapeutic effects of naringenin on bronchial pneumonia in children

Yao

Zhang

et al. 2021

Pharmacology Res & Perspec

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“…Необходимо подчеркнуть важность ранней диагностики в отношении тех аллергенов, с которыми возможно специфическое лечение у детей. АСИТ при респираторных аллергических заболеваниях подавляет аллергическое воспаление, уменьшает симптомы заболевания и дает уникальные долгосрочные эффекты; АСИТ следует применять даже у тех детей, которые имеют на момент обследования интермиттирующее течение заболевания, в качестве раннего лечения [20]. Необходимо помнить, что АСИТ полисенсибилизированным пациентам никоим образом не противопоказана [8,9,20]…”

Section: рис 1 частота сенсибилизации к D Farinae D Pteronyssinus и к обоим видам клещей одновременно у детей в возрасте от 5 до 17 лет иunclassified

Clinical and anamnestic characteristics and results of allergological testing in children with bronchial asthma and allergic rhinitis in case of allergy to house dust mites

Trusova¹,

Kamaev²,

Liashenko³

et al. 2021

Allergol. immunol. pediatr.

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House dust mites (HDM) are a common cause of allergies, however, it is not always easy to suspect a mite allergy from a patient's history. Objective: to determine clinical characteristics of patients, tactics for demonstrating the role of HDM sensitization in pediatric patients with allergic rhinitis (AR) and bronchial asthma (BA) with domestic sensitization. Materials and methods. The study included 420 patients, 256 boys, 164 girls, aged 5 to 17,9 years (mean 8,44 ± 3,06 years), with AR (100%) and AR in combination with BA (41,9%). The prick test on the forearm skin with water-soluble extracts was carried out and evaluated according to the standard method. The test was considered positive with a maximum wheal diameter of ≥3 mm 15 minutes after applying the prick. Results. Among patients with HDM sensitization (n=268), sensitization to both mites was detected in 218 cases (81,3%), and in 139 cases (51,9%) polysensitization to HDM allergens, house dust and epidermal allergens (cat, dog) was found. Patients noted persistent symptoms of nasal congestion, and rhinorrhea; the provoking factor was not determined by history in 46% of cases. In 69,8% of cases (97 children), it was impossible to isolate the leading allergen according to the history, since patients had contact with cats, dogs, dust, and polysensitization according to the prick tests. Nasal provocation test (NPT) with HDM allergens was performed in 92 children. Positive NPT was obtained in 83 cases (90,2%), negative in 9 cases (9,8%). Conclusions. With HDM sensitization, often (46%) the provoking factor is not determined by history. Monotonous symptoms are characteristic with the absence of obvious relationships with allergens, the location and activities of the child. In terms of frequency, the leading variant is sensitization to both mites D.pteronyssinus, D.farinae (81,3%), and polysensitization to HDM, house dust and cat and dog allergens (51,9%). NPT allows in 90% of cases to show the causal role of HDM allergens in polysensitized patients with insufficiently convincing anamnesis data.

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“…Through a well-defined immunologic mechanism, allergen immunotherapy (AIT) promotes regulatory T cells and cuts down the immune response induced by allergens 5 . According to current guidelines based on the most recent evidence, AIT should be offered to children with moderate to severe allergic rhinitis or controlled asthma starting from 5 years of age after an adequate risk-benefit assessment 1,6 .…”

Section: Introductionmentioning

confidence: 99%

“…Respiratory allergies are triggered by allergens that are present in domestic environments (dust, mould) as well as in the external environment (pollen). In this context, specific sublingual immunotherapy (SLIT) provides new and important therapeutic perspectives and represents an approach that is currently available for redirecting the inappropriate immune response in atopic patients 1,2 . SLIT represents an invaluable improvement that can change the clinical history of different types of Immunoglobulin (Ig)E-mediated allergic diseases.…”

Section: Introductionmentioning

confidence: 99%

Nasal Nitric Oxide and Nasal Cytology as Predictive Markers of Short-Term Sublingual Allergen-Specific Immunotherapy Efficacy in Children with Allergic Rhinitis

Parisi

Manti

Papale

et al. 2021

Am J Rhinol�Allergy

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Background Few studies have been conducted on the short-term response to sublingual immunotherapy (SLIT). Objective The purpose of our experimental trial was to evaluate if two markers such as nasal nitric oxide (nNO) and nasal cytology could be useful to identify a precocious clinical efficacy of SLIT treatment. Methods We enrolled 34 children aged 6 to 14 years old with diagnosis of allergic rhinitis (AR) and documented sensitization towards house dust mites. We started allergoid-monomeric tablets immunotherapy along with any conventional therapy for AR and we evaluated at baseline (T0), after one (T1), two (T2), three (T3), and six months (T6) the effects of the treatment through the study of: i) a visual analogue scale (VAS 1-10); ii) measurement of nNO; iii) measurement of FeNO; iv) nasal cytology; v) spirometry; and vi) evaluation of any conventional therapy. Results We observed an improvement in symptoms evaluated by global VAS (T0 vs. T6: 47.13 vs. 17.57; p < .05) and a statistically significant reduction of nNO (1035.2 ± 956.08 vs. 139.2 ± 59.01; p < .05). In this case, significance was reached when the patients completed the 6 months of treatment. Cytological evaluation revealed significant reduction in nasal eosinophils (T0 vs. T6: 87% vs. 16%; p < .01). Moreover, at T0, 56% of patients had also neutrophils that were reduced up to the 8% at T6 (p < .05). Conclusions Our data confirm the effectiveness of SLIT treatment from a clinical perspective and identifies two biomarkers, such as nNO and nasal cytology, as predictive of treatment efficacy in the short term.

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Allergen Immunotherapy in children with respiratory allergic diseases

Cited by 8 publications

References 91 publications

The therapeutic effects of naringenin on bronchial pneumonia in children

The therapeutic effects of naringenin on bronchial pneumonia in children

Clinical and anamnestic characteristics and results of allergological testing in children with bronchial asthma and allergic rhinitis in case of allergy to house dust mites

Nasal Nitric Oxide and Nasal Cytology as Predictive Markers of Short-Term Sublingual Allergen-Specific Immunotherapy Efficacy in Children with Allergic Rhinitis

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