Allergen immunotherapy enhances the immunosuppressive effects of Treg cells to alleviate allergic rhinitis by decreasing PU-1+ Treg cell numbers

Qiao, Yue-Long; Jiao, Wo-Er; Xu, Shunqing; Kong, Yonggang; Deng, Yuxiao; Yang, Rui; Hua, Qingquan; Chen, Shiming

doi:10.1016/j.intimp.2022.109187

Cited by 7 publications

(2 citation statements)

References 35 publications

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“…Interestingly, some previous reported immunal changes after 1 year of AIT. 21 , 22 , 23 , 24 , 25 However, the different allergen type (mite vs cedar pollinosis), treatment method (SCIT vs SLIT), and treatment population (adult vs children) may explain the different results. Our data also showed that the percentages of Treg, Breg, and Tfr in the 3 years group increased significantly.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and immunological changes of sublingual immunotherapy in pediatric allergic rhinitis

Zeng¹,

Xiao²,

Gao³

et al. 2023

World Allergy Organization Journal

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Section: Discussionmentioning

confidence: 99%

Efficacy and immunological changes of sublingual immunotherapy in pediatric allergic rhinitis

Zeng¹,

Xiao²,

Gao³

et al. 2023

World Allergy Organization Journal

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“…One of the mechanisms of AIT altering allergen-specific T cells is the switch from a Th2 to a Th1 cell-dominated immune response (immune deviation). Many clinical trial results in the past have proved this viewpoint—the immune effect of immunotherapy can reduce the secretion of Th2 cytokines and increase the secretion of Th1 cytokines 8 , 9 . Although there have been many reports on the immunomodulatory mechanism of AIT on AR, its mechanism of action is still not completely clear, and further research is needed.…”

Section: Introductionmentioning

confidence: 94%

Experimental observation of the effect of immunotherapy on CD4+ T cells and Th1/Th2 cytokines in mice with allergic rhinitis

Zhu

et al. 2023

Sci Rep

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The present study aims to investigate the effect of immunotherapy in a mouse model of allergic rhinitis (AR) and to explore the possible molecular mechanisms of action. An animal model of AR was established by sensitization and challenge of BALB/c mice with house dust mite (HDM) extract. The mice were injected subcutaneously with HDM for immunotherapy. AR nasal symptoms were evaluated according to the frequencies of nose rubbing and sneezing and the degree of rhinorrhea. The nasal mucosa and lung tissue architecture and inflammatory status by histological analysis; the infiltration of eosinophils in nasal lavage fluid (NALF) of mice was observed by Diff-Quik stain; ELISA-based quantification of serum HDM-specific IgE and TH1/TH2 cytokine concentration; and flow cytometry detected the number of serum CD4+/CD8+ cells to evaluate the mechanism of immunotherapy. It was found that after immunotherapy, the AR symptom score was reduced, the number of eosinophils in NALF was reduced, and the infiltration of inflammatory cells and tissue damage in the nasal mucosa and lung tissue were alleviated. Immunotherapy can increase the number of CD4+ T cells in the peripheral blood, increase the ratio of CD4+/CD8+ cells, increase the expression of Th1 cytokines such as IL-2 and IFN-γ, reduce the expression of Th2 cytokines such as IL-4 and IL-5. The results showed that repeated intraperitoneal injection of crude extract of HDM for sensitization, followed by nasal drops can effectively construct a mouse model of AR, and subcutaneous injection of immunotherapy in mice can reduce allergic inflammation in model mice and improve the inflammatory infiltration of the nasal cavity in allergic rhinitis. Immunotherapy can reduce the expression of inflammatory factors in AR, improve Th1/Th2 balance, and may play a role in the treatment of AR by improving the function of immune cells.

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Increased Nasal Blimp1 + Treg Cells After Sublingual Immunotherapy Reflect the Efficacy of Treatment in Allergic Rhinitis

Pan,

Zhang,

Geng

et al. 2024

Adv Ther

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Allergen immunotherapy enhances the immunosuppressive effects of Treg cells to alleviate allergic rhinitis by decreasing PU-1+ Treg cell numbers

Cited by 7 publications

References 35 publications

Efficacy and immunological changes of sublingual immunotherapy in pediatric allergic rhinitis

Efficacy and immunological changes of sublingual immunotherapy in pediatric allergic rhinitis

Experimental observation of the effect of immunotherapy on CD4+ T cells and Th1/Th2 cytokines in mice with allergic rhinitis

Increased Nasal Blimp1 + Treg Cells After Sublingual Immunotherapy Reflect the Efficacy of Treatment in Allergic Rhinitis

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