Allergen databases

Brusic, Vladimir; Millot, M.; Petrovsky, Nikolai; Gendel, Steven M.; Gigonzac, O.; Stelman, Steven J.

doi:10.1034/j.1398-9995.2003.00248.x

Cited by 59 publications

(42 citation statements)

References 33 publications

(30 reference statements)

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“…A number of allergen databases that differ with respect to the number of molecules listed as allergens and to the type of information displayed have been reviewed (Brusic et al, 2003) (Gendel and Jenkins, 2006;Mari et al, 2006;Schein et al, 2007;Gendel, 2009 In this opinion, only food allergens listed in the IUIS database as of December 2013 will be mentioned and discussed in the sections dedicated to specific allergenic foods, unless otherwise specified.…”

Section: Introduction and Nomenclaturementioning

confidence: 99%

Scientific Opinion on the evaluation of allergenic foods and food ingredients for labelling purposes

Products¹

2014

EFS2

115

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Following a request from the Food Safety Authority of Ireland, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel) was asked to deliver a scientific opinion on the evaluation of allergenic foods and food ingredients for labelling purposes. In view of the request, the NDA Panel decided to update its previous opinions relative to food ingredients or substances with known allergenic potential listed in Annex IIIa of 2003/89/EC, as amended. These include cereals containing gluten, milk and dairy products, eggs, nuts, peanuts, soy, fish, crustaceans, molluscs, celery, lupin, sesame, mustard and sulphites. The opinion relates to immunoglobulin (Ig)E-and non-IgE-mediated food allergy, to coeliac disease and to adverse reactions to sulphites in food, and it does not address non-immune-mediated adverse reactions to food. It includes information on the prevalence of food allergy in unselected populations, proteins identified as food allergens, cross-reactivities, the effects of food processing on the allergenicity of foods and ingredients, methods for the detection of allergens and allergenic foods, doses observed to trigger adverse reactions in sensitive individuals and risk assessment methodologies that have been used to derive individual and population thresholds for selected allergenic foods. The present opinion relates to immunoglobulin (Ig)E-and non-IgE-mediated food allergy, to coeliac disease and to adverse reactions to sulphites in food, and it does not address non-immune-mediated adverse reactions to food. For each food ingredient or substance listed in Annex IIIa, it includes information on the prevalence of food allergy in unselected populations, on proteins identified as food allergens, on cross-reactivities, on the effects of food processing on the allergenicity of foods and ingredients, on methods for the detection of allergens and allergenic foods, and on doses observed to trigger adverse reactions in sensitive individuals.Immune-mediated adverse reactions to foods manifest with clinical signs and symptoms of variable severity and duration, which may affect different organs and systems. Anaphylactic reactions to food are IgE mediated and may occur at any age. Non-IgE-mediated food allergy includes a wide range of diseases, including protein-induced enterocolitis and eosinophilic oesophagitis.A careful family and clinical history are the basis for diagnosis of food allergy. Food diaries, skin prick tests (SPTs), allergen-specific IgE measurements, food elimination diets and food challenges are part of the standard protocol for the diagnosis of food allergy. A positive SPT indicates sensitisation to the tested food, but it is not diagnostic of food allergy. Allergen-specific serum IgE antibodies similarly denote sensitisation to a particular food, but they are not diagnostic without a clinical history or food challenge. The use of atopy patch tests for the diagnosis of food allergy is controversial. Other available tests have no current role in the diagnosis of food allergy. Diag...

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Section: Introduction and Nomenclaturementioning

confidence: 99%

Scientific Opinion on the evaluation of allergenic foods and food ingredients for labelling purposes

Products¹

2014

EFS2

115

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“…Therefore, allergen databases represent very crucial resources for basic allergy research as they are involved in archival of available allergen knowledge. Many allergen-specific databases have been developed in the past few years although they differ from each other with respect to their objectives, type of data archived, accessibility of contents, and the level of annotation and applications [30]. In addition to dedicated allergen databases, primary bioinformatics databases also document significant data on allergens.…”

Section: Allergen Databasesmentioning

confidence: 99%

Databases and Algorithms in Allergen Informatics

Kadam¹,

Sawant²,

Jayaraman³

et al. 2016

Bioinformatics - Updated Features and Applications

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Allergic diseases are considered as one of the major health problems worldwide due to their increasing prevalence. Advancements in genomic, proteomic, and analytical techniques have resulted in considerable progress in the field of allergology, which has led to accumulation of huge amount of data. Allergen bioinformatics comprises allergenrelated data resources and computational methods/tools, which deal with an efficient archival, management, and analysis of allergological data. Significant work has been done in the area of allergen bioinformatics that has proven pivotal for the development and progress of this field. In this chapter, we describe the current status of databases and algorithms, encompassing the field of allergen bioinformatics by examining work carried out thus far with respect to features such as allergens and allergenicity, allergen databases, algorithms/tools for allergen/allergenicity prediction, allergen epitope prediction, and allergenic cross-reactivity assessment. This chapter illustrates concepts and algorithms in allergen bioinformatics, as well as it outlines the key areas for potential development in allergology field.

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“…Other databases are specialized on allergens, as Immune Epitope Database [16]. Lists of databases of allergens or bioactive peptides are available in literature [17] or by surfing the net. Similarly, for bioactive peptides I just quote the BIOPEP resource [18] that includes subsections for allergens.…”

Section: Bioactive Peptides Databasesmentioning

confidence: 99%

Bioinformatic resources for the investigation of proteins and proteomes

Facchiano¹

2017

Peptidomics

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Experimental techniques in omics sciences need strong support of bioinformatics tools for the data management, analysis and interpretation. Scientific community develops continuously new databases and tools. They make it possible the comparison of new experimental data with the existing ones, to gain new knowledge. Bioinformatics assists proteomics scientists for protein identification from experimental data, management of the huge data produced, investigation of molecular mechanisms of protein functions, their roles in biochemical pathways, and functional interpretation of biological processes. This article introduces the main bioinformatics resources for investigation in the protein world, with references to analyses performed by means of free tools available on the net.

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Allergen databases

Cited by 59 publications

References 33 publications

Scientific Opinion on the evaluation of allergenic foods and food ingredients for labelling purposes

Scientific Opinion on the evaluation of allergenic foods and food ingredients for labelling purposes

Databases and Algorithms in Allergen Informatics

Bioinformatic resources for the investigation of proteins and proteomes

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